Allele Dmel\Pp1-87B¹

General Information
Symbol	Dmel\Pp1-87B¹	Species	D. melanogaster
Name		FlyBase ID	FBal0013933
Feature type	allele	Associated gene	Dmel\Pp1-87B
Also Known As	PP1α87B¹, Su(var)3-6⁰¹, Su-var(3)6⁰¹, Su(var)3-6¹

Map ( GBrowse )
Allele class	hypomorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (Wustmann and Spatz, 1993, Swanhart et al., 2007)
Mutagen	ethyl methanesulfonate (Reuter et al., 1986)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 3R:8,250,753..8,250,753 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=G8250753A pr_change=G220S\|Pp1-87B-PA reported_pr_change=G220S (Dombradi and Cohen, 1992)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: G220S. (Dombradi and Cohen, 1992)
Cytology	Polytene chromosomes normal.
Phenotypic Data
Phenotypic Class
	lethal (with Pp1-87B^87Bg-3) (Kirchner et al., 2007) lethal \| recessive (Reuter et al., 1986) non-suppressor of variegation, with P{wA^R}w^A (Balasov et al., 2000) partially lethal - majority die (Baksa et al., 1993) partially lethal - majority die (with Pp1-87B^87Bg-3) (Vereshchagina et al., 2004) partially lethal - majority die \| recessive (Reuter et al., 1987) suppressor of variegation, with Byron (Sass and Henikoff, 1998) suppressor of variegation, with In(1)w^m4 (Sass and Henikoff, 1998) suppressor of variegation, with In(1)w^m4h (Baksa et al., 1993) suppressor of variegation, with In(2R)bw^VDe2 (Sass and Henikoff, 1998) suppressor of variegation, with P{wA^R}41A (Sass and Henikoff, 1998) suppressor of variegation \| dominant, with In(1)w^m4h (Reuter et al., 1986)
Phenotype Manifest In

Detailed Description
	Statement Reference Pp1-87B[1] heterozygous embryos appear wild-type and hatch normally. (Tan et al., 2008) Pp1-87B¹/Pp1-87B^87Bg-3 animals die during pupariation, and until pupariation, do not lag behind in development compared to their control siblings. (Kirchner et al., 2007) Homozygotes and heterozygotes show no muscle detachment or indirect flight muscle phenotypes. (Raghavan et al., 2000) Suppresses the position effect variegation at the w locus caused by In(1)w^m4 and suppresses the position effect variegation at the bw locus caused by In(2R)bw^VDe2 and Byron. Also suppresses the position effect variegation of w seen in the P{wA^R}41A insertion. (Sass and Henikoff, 1998) Strong suppressor levels of position effect vareigation and normal mitosis in neuroblasts or ganglion mother cells. (Baksa et al., 1993) Dominant suppressor of position effect variegation at the w locus caused by In(1)w^m4h. (Reuter et al., 1986) shows some reduction in viability in trans heterozygotes with some alleles of l(3)87Bg; in one case a clear maternal effect is noted.
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference Pp1-87B^87Bg-3/Pp1-87B¹ has lethal phenotype, suppressible by flw^{Scer\UAS.T:Ivir\HA1}/Scer\GAL4^arm.PS (Kirchner et al., 2007) Pp1-87B^87Bg-3/Pp1-87B¹ has lethal phenotype, suppressible by Scer\GAL4^arm.PS/Pp1α-96A^{Scer\UAS.T:Ivir\HA1} (Kirchner et al., 2007)
NOT suppressed by
Statement Reference Pp1α-96A², Pp1-87B^87Bg-3/Pp1-87B¹ has lethal phenotype, non-suppressible by flw^{Scer\UAS.T:Ivir\HA1}/Scer\GAL4^arm.PS (Kirchner et al., 2007)
Enhancer of
Statement Reference Pp1-87B[+]/Pp1-87B¹ is an enhancer of visible phenotype of Scer\GAL4^vg.PM, put^Scer\UAS.cMa (Bennett et al., 2003) Pp1-87B¹ is an enhancer of visible phenotype of Ret^GMR.PR (Read et al., 2005) Pp1-87B¹ is an enhancer of visible phenotype of Ret^MEN2B.GMR (Read et al., 2005)
NOT Enhancer of
Statement Reference Pp1-87B¹ is a non-enhancer of visible phenotype of Ret^MEN2A.GMR (Read et al., 2005)
Suppressor of
Statement Reference Pp1-87B[+]/Pp1-87B¹ is a suppressor \| partially of visible \| homeotic phenotype of trx^B11/trx¹ (Rudenko et al., 2003) Pp1-87B[+]/Pp1-87B¹ is a suppressor \| partially of visible \| homeotic phenotype of trx^E2/trx¹ (Rudenko et al., 2003)
NOT Suppressor of
Statement Reference Pp1-87B¹ is a non-suppressor of visible phenotype of Ret^MEN2A.GMR (Read et al., 2005)
Other
Statement Reference NiPp1^{Scer\UAS.T:Avic\GFP-EGFP}, Pp1-87B¹, Scer\GAL4^vg.PM has visible phenotype (Parker et al., 2002, Parker et al., 2002) Pp1-87B¹, mars¹ has hatching behavior defective phenotype (Tan et al., 2008) Pp1-87B¹, mars¹ has lethal \| embryonic stage phenotype (Tan et al., 2008)
Phenotype Manifest In
Enhancer of
Statement Reference Pp1-87B[+]/Pp1-87B¹ is an enhancer of posterior wing margin phenotype of Nop17l^{Scer\UAS.T:Zzzz\His6,T:Hsap\MYC}, Scer\GAL4^Bx-MS1096 (Bennett et al., 2006) Pp1-87B[+]/Pp1-87B¹ is an enhancer of wing \| posterior compartment phenotype of Scer\GAL4^vg.int2.1, put^Scer\UAS.cMa (Bennett and Alphey, 2002) Pp1-87B[+]/Pp1-87B¹ is an enhancer of wing phenotype of Nop17l^{Scer\UAS.T:Zzzz\His6,T:Hsap\MYC}, Scer\GAL4^Bx-MS1096 (Bennett et al., 2006) Pp1-87B[+]/Pp1-87B¹ is an enhancer of wing phenotype of Scer\GAL4^vg.PM, put^Scer\UAS.cMa (Bennett et al., 2003) Pp1-87B¹ is an enhancer of eye phenotype of Ret^GMR.PR (Read et al., 2005) Pp1-87B¹ is an enhancer of eye phenotype of Ret^MEN2B.GMR (Read et al., 2005)
NOT Enhancer of
Statement Reference Pp1-87B¹ is a non-enhancer of eye phenotype of Ret^MEN2A.GMR (Read et al., 2005)
Suppressor of
Statement Reference Pp1-87B[+]/Pp1-87B¹ is a suppressor \| partially of haltere \| ectopic phenotype of trx^B11/trx¹ (Rudenko et al., 2003) Pp1-87B[+]/Pp1-87B¹ is a suppressor \| partially of haltere \| ectopic phenotype of trx^E2/trx¹ (Rudenko et al., 2003) Pp1-87B[+]/Pp1-87B¹ is a suppressor \| partially of wing phenotype of trx^B11/trx¹ (Rudenko et al., 2003) Pp1-87B[+]/Pp1-87B¹ is a suppressor \| partially of wing phenotype of trx^E2/trx¹ (Rudenko et al., 2003)
NOT Suppressor of
Statement Reference Pp1-87B¹ is a non-suppressor of eye phenotype of Ret^MEN2A.GMR (Read et al., 2005)
Other
Statement Reference NiPp1^{Scer\UAS.T:Avic\GFP-EGFP}, Pp1-87B¹, Scer\GAL4^vg.PM has wing phenotype (Parker et al., 2002, Parker et al., 2002)
Additional Comments
Genetic Interactions
Statement Reference Embryos laid by flies heterozygous for mars[1] and Pp1-87B[1] show a significantly reduced hatch ratio. (Tan et al., 2008) Pp1-87B¹/Pp1-87B^87Bg-3 Pp1α-96A²/Pp1α-96A² double mutant animals die slightly earlier than Pp1-87B¹/Pp1-87B^87Bg-3 single mutants and pupariate 1-2 days later than their siblings. (Kirchner et al., 2007) Expression of Nop17l[Scer\UAS.T:Zzzz\His6,T:Hsap\MYC] under the control of Scer\GAL4[Bx-MS1096] in Pp1-87B[1]/+ wings results in severely crumpled and reduced wings. (Bennett et al., 2006) The modest wing overgrowth phenotype caused by expression of put^Scer\UAS.cMa under the control of Scer\GAL4^vg.PM is enhanced by Pp1-87B¹/+. (Bennett et al., 2003) Pp1-87B[1] dominantly suppresses the transformation of wing to haltere seen in trx[1]/trx[E2] flies; 31% show strong transformation, 39% show weak transformation and 30% show no transformation. Pp1-87B[1] dominantly suppresses the transformation of wing to haltere seen in trx[1]/trx[B11] flies; 27% show strong transformation, 24% show weak transformation and 49% show no transformation. (Rudenko et al., 2003) Flies expressing NiPp1^{Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^vg.PM which are also carrying Pp1-87B¹ have crumpled wings. (Parker et al., 2002) The effect of loss of one copy of Pp1-87B¹ cannot be rescued by P element mediated transformation with Su(var)3-7. (Reuter et al., 1990)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	Pp1-87B¹ is rescued by Pp1-87B^+t5.8 (Baksa et al., 1993) Pp1-87B^87Bg-3/Pp1-87B¹ is rescued by Pp1-87B^{Scer\UAS.T:Ivir\HA1}/Scer\GAL4^arm.PS (Kirchner et al., 2007)
Comments	The suppressor phenotype of Pp1-87B¹ on In(1)w^m4h is rescued by Pp1-87B^+t5.8. The lethality of Pp1-87B¹ is rescued by Pp1-87B^+t5.8. (Baksa et al., 1993)
Stocks ( 1 )
Bloomington	6207 Pp1-87B¹ e¹ ro¹/TM3, Sb¹ Ser¹
Notes on Origin
Discoverer

Comments
	Not suppressed by zip alleles. (Vereshchagina et al., 2004) Isolated as a suppressor of position effect variegation at the w locus in flies carrying In(1)w^m4h, and a dominant enhancer of position effect variegation, E(var)c101¹. (Reuter et al., 1986)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	Pp1-87^B1 (Read et al., 2005) Pp1-87B¹ (Geng and MacDonald, 2007, Cook et al., 2009.2.28, Christensen et al., 2009.7.22, Tan et al., 2008) Pp1-87B^Suvar(3)6-01 (Bennett and Alphey, 2002) PP1α87B¹ (Vereshchagina et al., 2004, Parker et al., 2002, Bennett et al., 2003, Kirchner et al., 2007, Swanhart et al., 2007, Rudenko et al., 2003, Bennett et al., 2006) Su(var)3-6⁰¹ (Erhardt et al., 2003, Hwang et al., 2001, Gvozdev et al., 2000, Balasov et al., 2000, Naumova et al., 2000, Sass and Henikoff, 1998) Su(var)3-6¹ (Kurenova et al., 1998, Reuter et al., 1990, Reuter et al., 1987, ) Su-var(3)6 (Dombradi and Cohen, 1992) Su-var(3)6⁰¹ (Riedel, 1999, Wustmann and Spatz, 1993, Baksa et al., 1993, Reuter et al., 1986)
Name Synonym
Secondary FlyBase IDs

References ( 29 )

Generate a list of	All references relating to this allele ( 29 )

List References by type	Research paper ( 23 ) Review ( 2 ) Personal communication to FlyBase ( 2 ) Abstract ( 2 )
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Allele Dmel\Pp1-87B1

Allele Dmel\Pp1-87B¹