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General Information
Symbol
Dmel\Psc1
Species
D. melanogaster
Name
FlyBase ID
FBal0013980
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
PscIIN48
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Psc1 dominantly leads to ectopic sex comb teeth on the second leg of males, as compared to controls.

Psc1 heterozygous males display a homeotic transformation of the mesothoracic legs into prothoracic legs manifesting as extra sex combs.

One copy of Psc1 is unable to suppress position effect variegation (PEV) at the w locus caused by In(1)wm4.

One copy of Psc1 is unable to suppress the telomeric position effect (TPE) in stocks carrying a variegating P{hsp26-pt-T}39C-5 insertion at the telomere of the left arm of chromosome two.

Psc1 embryos from heterozygous mothers show segregation defects in anaphase and telophase as judged by the presence of chromatin bridges. Most of these chromatin bridges are probably resolved because large irregularly-shaped nuclei and polyploid nuclei are only seen at a low penetrance. Psc1 embryos also show a higher level of "nuclear fallout", a process that removes nuclei with abnormal mitoses, than wild-type embryos. Fallout nuclei tend to be observed in pairs or clusters and have a late telophase appearance. There is no evidence of metaphase defects in these embryos although a small number show chromatin bridges that persist to the prometaphase stage.

Psc1 males have ectopic sex combs on the second and third leg.

Psc1/+ has no effect on the telomeric position effect (TPE) of P{hsp26-pt-T}39C-5. Psc1/+ suppresses the telomeric position effect (TPE) of P{hsp26-pt-T}39C-27, P{hsp26-pt-T}39C-31 and P{wA}4-4.

A significant change in repression of the wH19.UZA gene compared to offspring from the same cross carrying the balancer chromosome is observed in Psc1 flies. Transgenic flies with Psc1 and the wH19.UZA gene, show de-repression in the eye phenotype when compared to non-mutant control siblings.

Transformation of second to first leg.

Shows no dominant effect on telomeric Position Effect Variegation (PEV) in stocks carrying a variegating w+mW.hs allele at the telomeres of the second and third chromosome.

Loss of function for homeosis, with some gain of function effects.

Mutation changes the level of w expression in ph-plac+3 flies; eye colour is darker.

Slight suppression of z1 In(1)wm4 but strongly suppresses z1 In(1)rst3. Suppressor of z1 wzl, zv77h wzl and z1 wzm but has no effect on zv77h wzm.

Has a dominant adult homeotic effect.

No homeotic phenotype and the mutation cannot enhance the homeotic phenotypes of Pc group mutants (FBrf0049524). Heterozygotes with Df(1)ph-2 are lethal.

In z1 wzm strain mutation causes reduction of eye pigmentation. Slightly suppress w phenotype in a e(y) background.

Embryonic lethal or semi-lethal when heterozygous with ph-d2. Unhatched larvae carry segmentation defects or polarity defects.

Lack longitudinal tracts but longitudinal glia differentiate though fail to form an orientated scaffold.

Homozygous embryos have head defects.

Hypomorphic with respect to homeotic function.

Does not exhibit dominant flightlessness.

Homozygous embryos show partial transformation of head and thorax into abdominal structures. This phenotype is enhanced in combination with other Pc like mutants. Heterozygous males sometimes have sex combs on the second and third legs.

Embryos have head defects, with a transformation of head, thorax and abdomen segments into more posterior structures. In Psc1 Asxunspecified double mutants, all denticle bands are similar to each other, and resemble A8 of wild-type embryos, although the thorax appears less transformed as the Keilin's organs are present. Head involution does not occur. A prominent abdominal denticle appears on the dorsal surface of the head and a few abdominal denticles are found behind the floor of the pharynx. Psc1 Asxunspecified Pclunspecified triple mutant embryos are characterised by a tandem array of posterior abdominal segments including up to four abdominal denticle bands in the head region. This phenotype is suppressed in embryos also lacking the bithorax complex region.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

Psc1 has visible | dominant phenotype, enhanceable by psq[+]/psq02403

NOT Enhanced by
Statement
Reference

Psc1 has visible | homeotic phenotype, non-enhanceable by dom14/dom[+]

Suppressed by
Statement
Reference

Psc1 has homeotic phenotype, suppressible | partially by Marcal1[+]/Marcal1del

Enhancer of
Statement
Reference

Psc[+]/Psc1 is an enhancer of visible | dominant | homeotic phenotype of ash117, trxB11/trx[+]

Psc[+]/Psc1 is an enhancer of visible | dominant | homeotic phenotype of brm[+]/brm2, trxE2

Psc[+]/Psc1 is an enhancer of visible | recessive | homeotic phenotype of mxcM1

NOT Enhancer of
Statement
Reference

Psc[+]/Psc1 is a non-enhancer of eye color defective phenotype of wdsRNA.GMR/wdsRNA.GMR

Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference

Psc[+]/Psc1 is a non-suppressor of eye color defective phenotype of wdsRNA.GMR/wdsRNA.GMR

Other
Phenotype Manifest In
Enhanced by
Statement
Reference

Psc1 has sex comb tooth | ectopic phenotype, enhanceable by mbf1[+]/mbf12

Psc1, mbf1[+]/mbf12 has sex comb tooth | ectopic phenotype, enhanceable by mbf1[+]/mbf12

Psc1 has sex comb tooth | ectopic phenotype, enhanceable by pcm[+]/pcmhs.PG

Psc1 has sex comb tooth | ectopic phenotype, enhanceable by E(z)[+]/E(z)731

Psc1 has sex comb tooth | ectopic phenotype, enhanceable by pcmhs.PG/mbf1[+]/mbf12, pcmΔ1/pcmΔ1

Psc1 has leg phenotype, enhanceable by psq[+]/psq02403

Psc1 has sex comb | ectopic phenotype, enhanceable by psq[+]/psq02403

Psc1 has phenotype, enhanceable by mxcM1

NOT Enhanced by
Statement
Reference

Psc1 has sex comb tooth | ectopic phenotype, non-enhanceable by mbf1[+]/mbf12/mbf1+t4574

Psc1 has sex comb | ectopic phenotype, non-enhanceable by pds5e3

Psc1 has sex comb | ectopic phenotype, non-enhanceable by pds5e6

Psc1 has sex comb | supernumerary phenotype, non-enhanceable by Spps1/Spps1

Psc1 has phenotype, non-enhanceable by lolalk02512/lolal[+]

Psc1 has phenotype, non-enhanceable by Alhunspecified

Psc1 has mesothoracic leg phenotype, non-enhanceable by dom14/dom[+]

Suppressed by
Statement
Reference

Psc1 has sex comb tooth | ectopic phenotype, suppressible | partially by pcm5/pcm5

Psc1, mbf1[+]/mbf12 has posterior wing margin | male phenotype, suppressible by pcmΔ1

Psc1 has sex comb phenotype, suppressible | partially by Marcal1[+]/Marcal1del

Psc1 has sex comb | ectopic phenotype, suppressible | partially by vtd6

Psc1 has sex comb | ectopic phenotype, suppressible | partially by vtd80Fh-36

NOT suppressed by
Statement
Reference

Psc1 has sex comb tooth | ectopic phenotype, non-suppressible by pcmhs.PG, pcmΔ1/pcmΔ1

Psc1 has sex comb tooth | ectopic phenotype, non-suppressible by mbf1[+]/mbf12, pcmΔ1/pcmΔ1

Psc1 has sex comb tooth | ectopic phenotype, non-suppressible by pcmhs.PG, pcm5/pcm5

Psc1 has sex comb tooth | ectopic phenotype, non-suppressible by mbf1[+]/mbf12, pcm5/pcm5

Psc1 has sex comb | ectopic phenotype, non-suppressible by SMC1exc46

Psc1 has sex comb | ectopic phenotype, non-suppressible by Nipped-B407

Psc1 has mesothoracic leg & sex comb tooth | ectopic phenotype, non-suppressible by Df(2R)ED3921

Psc1 has metathoracic leg & sex comb tooth | ectopic phenotype, non-suppressible by Df(2R)ED3921

Psc1 has phenotype, non-suppressible by lolalk02512/lolal[+]

Psc1 has phenotype, non-suppressible by Alhunspecified

Enhancer of
Statement
Reference

Psc[+]/Psc1 is an enhancer of adult abdominal segment 4 | ectopic phenotype of E(z)Trm

Psc[+]/Psc1 is an enhancer of adult abdominal segment 5 phenotype of E(z)Trm

Psc[+]/Psc1 is an enhancer of adult metathoracic segment phenotype of ash117, trxB11/trx[+]

Psc[+]/Psc1 is an enhancer of adult metathoracic segment phenotype of brm[+]/brm2, trxE2

Psc1 is an enhancer of wing phenotype of ciW

Psc[+]/Psc1 is an enhancer of leg | ectopic phenotype of hhMrt

Psc[+]/Psc1 is an enhancer of wing | anterior phenotype of hhMrt

Psc1 is an enhancer of phenotype of mxcM1

NOT Enhancer of
Statement
Reference

Psc[+]/Psc1 is a non-enhancer of phenotype of lolalk02512

Psc1 is a non-enhancer of eye phenotype of CycEJP

Suppressor of
Statement
Reference

Psc1 is a suppressor of wing phenotype of sdFab-X

Psc[+]/Psc1 is a suppressor | partially of adult mesothoracic segment | ectopic phenotype of E(z)Trm

Psc[+]/Psc1 is a suppressor | partially of adult metathoracic segment phenotype of E(z)Trm

Psc[+]/Psc1 is a suppressor of adult prothoracic segment phenotype of E(z)Trm

Psc1 is a suppressor of wing phenotype of ctpN2s

Psc1 is a suppressor of wing phenotype of ctn2s

Psc[+]/Psc1 is a suppressor of phenotype of z1

NOT Suppressor of
Statement
Reference

Psc[+]/Psc1 is a non-suppressor of phenotype of lolalk02512

Psc1 is a non-suppressor of eye phenotype of CycEJP

Psc[+]/Psc1 is a non-suppressor of eye phenotype of Scer\GAL4ey.PH, asf1UAS.cMa

Psc1 is a non-suppressor of phenotype of w4.Ubx.bxd:pbx.ΔBC3

Other
Statement
Reference

MRG15j6A3, Psc[+]/Psc1 has mesothoracic leg & sex comb | ectopic phenotype

MRG15j6A3, Psc[+]/Psc1 has metathoracic leg & sex comb | ectopic phenotype

Additional Comments
Genetic Interactions
Statement
Reference

Psc1, mbf12 double heterozygotes show adult wing defects along the posterior wing margin in males, which are suppressed by pcmΔ1 hemizygosity.

The ectopic sex comb teeth phenotype of Psc1 heterozygous males is partially suppressed by homozygosity for either pcmΔ1 or pcm5 and is exacerbated by the heat-shock-induced expression of pcmhs.PG, by heterozygosity for E(z)731 or (incrementally) by heterozygosity and homozygosity for mbf12; the phenotype suppression by either pcmΔ1 or pcm5 homozygosity is annulled either by heterozygosity for mbf12 or by the heat-shock-induced expression of pcmhs.PG; the phenotype enhancement induced by mbf12 heterozygosity is annulled by one copy of mbf1+t4574. The ectopic sex comb teeth phenotype of Psc1 heterozygous males is also exacerbated by the triple combinations of heterozygosity for mbf12, homozygosity for either pcmΔ1 or pcm5 and heat-shock-induced expression of pcmhs.PG.

The formation of ectopic wing veins observed in adult flies expressing Marcal1Scer\UAS.cBa under the control of Scer\GAL4tub.PU is ameliorated by combination with a single copy of Psc1.

The homeotic transformation of the mesothoracic legs into prothoracic legs manifesting as extra sex combs characteristic for Psc1/+ males is partially suppressed by Marcal1del heterozygosity but combination with two copies of Marcal1del is lethal.

Psc1 +/+ Su(z)24-31 animals are not viable.

rept06945 Psc1 double heterozygous males have ectopic sex combs on the second and third legs (40% and 2% of flies respectively).

Psc1/+ ; reptex1/+ double heterozygous males do not have ectopic sex combs on either the second or third legs.

Psc1/+ ; MRG15j6A3/+ double heterozygous males have ectopic sex combs on the second and third legs (38% and 11% of flies respectively).

MRG15ex1 shows no interaction (in terms of ectopic sex comb phenotype) when in double heterozygous combination with Psc1.

Df(2R)ED3921 fails to suppress the ectopic sex comb phenotype of Psc1 mutants.

The addition of heterozygous, Psc1 to lolalk02512/+ animals shows enhancement or suppression.

Psc1 psq02403 heterozygous males show a remarkable increase in the number of ectopic sex comb teeth compared to Psc1 single heterozygotes.

Psc1/+ does not suppress the rough eye phenotype due to Scer\GAL4ey.PH; asf1Scer\UAS.cMa.

No significant modification of the number of sex combs is seen in Psc1/+ corto420/+ double heterozygotes compared to Psc1/+ single heterozygotes.

invW/Psc1 wings exhibit a wing phenotype (similar to the gain of function ci phenotype).

Mutant heterozygotes show a strong suppression of the eye phenotype see in P{UAS-lacZ.Abd-B.5F24} leading to darker eyes.

The addition of Psc1 suppresses the Pairing sensitive silencing effect seen in wMcp.scs'.21 and wMcp.y.scs'.1 and strongly suppresses the double insertion combinations of wMcp.scs'.21/ywe.Mcp.1 (P{Mcp-w#21}124/+, P{Mcp-wy#1}183/+) and the eye colour phenotype of wMcp.y.scs'.1/ywe.Mcp.2 (P{Mcp-yw#1}103/+, P{Mcp-wy#2}50/+).

Weak suppressor of eye pigment phenotype of wT81.

Hemizygous mxcM1 males show weak homeotic phenotypes. Strong enhancement of homeotic transformations is seen in mxcM1/Y in trans with one mutant copy of Psc1.

Has no effect on the phenotypes of ct2s, ct4s and ct6, where the wing margin enhancer is completely blocked.

Suppression of z1 eye color, towards wild-type colour. Eye color of heterozygous females which are also z1/z1 : dull red. Eye color of heterozygous males which are also z1, wis/Y: almost wild type.

Dominant suppressor of the z-w interaction.

Dominant suppressor of the z1-w interaction.

Dominant suppressor of the z1 interaction with w.

Xenogenetic Interactions
Statement
Reference

The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1Scer\UAS.cBa under the control of Scer\GAL4Bx-MS1096 is ameliorated by combination with a single copy of Psc1.

Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Comments
Comments

Alleles of Su(z)2 do not complement Psc1.

Fails to complement: Su(z)2D.c16. Fails to complement: Su(z)21. Complements: Su(z)21.a1. Complements: Su(z)21.b7. Complements: Su(z)2Arp.1. Complements: Su(z)2Arp.2. Fails to complement: Su(z)24. Complements: Su(z)31. Fails to complement: Su(z)31.y. Complements: Su(z)2Arp1. Complements: Su(z)2Arp.4. Complements: l(2)49Dc1.

abd-A is seen in parasegments 2 to 6 at 9 hours, by 12 hours expression has become much weaker. By 9 hours Abd-B is seen throughout the A-P axis.

Weak derepression of en expression.

Lethal when heterozygous with Su(z)21 or Su(z)25, and shows reduced viability when heterozygous with Su(z)24.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
References (69)