FB2025_01 , released February 20, 2025
Allele: Dmel\Pur1
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General Information
Symbol
Dmel\Pur1
Species
D. melanogaster
Name
recessive
FlyBase ID
FBal0014013
Feature type
allele
Associated gene
Dmel\Pu
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
(O'Donnell et al., 1989, Mackay et al., 1985)
Progenitor genotype
Caused by aberration
In(2R)Pur1
Cytology
Description

roo insertion in the eye specific region.

(McLean et al., 1990)

Mutation spans the head specific region and the distal lethal region.

(O'Donnell et al., 1989)

GTP cyclohydrolase activity is severely reduced in the adult head, nearly normal in the adult body and moderately reduced in the prepupa of homozygotes.

(Mackay et al., 1985)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  nervous system disease
      modeled by AtpĪ±CJ10
      (Talsma et al., 2014)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Pur1 heterozygotes do not exhibit a eye degeneration phenotype.

      (Ferdousy et al., 2011)

      Slight transient dilution of eye color in freshly emerged heterozygotes.

      (Lindsley and Zimm, 1992)

      Recessive eye colour phenotype.

      (McLean et al., 1990)

      Homozygous viable.

      (O'Donnell et al., 1989, O'Donnell et al., 1989)

      Eye colour: white to pale-orange. Severely reduced pteridine levels in the head.

      (Mackay et al., 1985)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Pur1 is an enhancer of eye phenotype of Scer\GAL4GMR.PF, Ube3aUAS.Tag:FLAG

      (Ferdousy et al., 2011)

      Pur1 is an enhancer of interommatidial bristle phenotype of Scer\GAL4GMR.PF, Ube3aUAS.Tag:FLAG

      (Ferdousy et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      A Pur1, heterozygous background enhances the Scer\GAL4GMR.PF-> Ube3aCA.Scer\UAS.T:Zzzz\FLAG rough eye phenotype, causing a glazed appearance, loss of inter-ommatidial bristles and a yellowish discoloration, indicative of underlying neurodegeneration.

      (Ferdousy et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (2)
      Stocks (1)
      Notes on Origin
      Discoverer

      Ives.

      (Lindsley and Zimm, 1992)
      Comments
      Comments

      The viability and eye phenotype in trans with other Pu alleles has been determined.

      (Mackay et al., 1985)

      Class I allele: eye specific phenotypes.

      (O'Donnell et al., 1989)

      ry protein levels are less than normal in the eyes of this mutant.

      (Reaume et al., 1991)

      GTP CH activity moderately reduced in prepupae and nearly normal in adult bodies of homozygotes; activity appears to be virtually absent in adult heads.

      (Lindsley and Zimm, 1992)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Pur1
      (Ferdousy et al., 2011, Weisberg and O'Donnell, 1986)
      Name Synonyms
      recessive
      Secondary FlyBase IDs
        References (13)