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General Information
Symbol
Dmel\PurAA17
Species
D. melanogaster
Name
FlyBase ID
FBal0014017
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
PuAA17
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous embryos have ectopically migrating tracheal branches and tracheal cells. Ectopic looping of the dorsal branches is seen and the dorsal trunk is sometimes convoluted. In the most severe cases, rounded "run-away" tracheal cells are seen throughout the embryo and there is a complete loss of the tracheal network.

84% of heterozygous embryos show ectopic tracheal migration.

Embryos have completely unpigmented and weak cuticles.

Eye colour: mutant in trans with a homozygous viable Pu allele.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference
Suppressed by
Statement
Reference
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The penetrance and severity of the ectopic tracheal migration phenotype is increased in PurAA17 awdj2A4 double heterozygous embryos compared to either single heterozygote.

The penetrance and severity of the ectopic tracheal migration phenotype is increased in PurAA17/+ shi2 double mutant embryos compared to either single mutant.

The opposing tracheal phenotypes of PurAA17/+ and btlH82Δ3/+ single heterozygous embryos (ectopic migration and lack of migration respectively) are both partially suppressed in PurAA17/+ btlH82Δ3/+ double heterozygous embryos.

The opposing tracheal phenotypes of PurAA17/+ and Catsup26/+ single heterozygous embryos (ectopic migration and lack of migration respectively) are both partially suppressed in PurAA17/+ Catsup26/+ double heterozygous embryos.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

The viability in trans with other Pu alleles has been determined.

Class II Pu allele.

Class II allele.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (6)