Allele Dmel\pum³

General Information
Symbol	Dmel\pum³	Species	D. melanogaster
Name		FlyBase ID	FBal0014074
Feature type	allele	Associated gene	Dmel\pum
Also Known As	pum^ET3

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Tearle and Nusslein-Volhard, 1987)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	visible (with pum¹) (Kim et al., 2012) visible (with pum⁷) (Kim et al., 2012) visible (with pum⁰¹⁶⁸⁸) (Kim et al., 2012) visible (with pum^Msc) (Kim et al., 2012)
Phenotype Manifest In
	macrochaeta \| ectopic (with pum⁷) (Kim et al., 2012) macrochaeta \| ectopic (with pum⁰¹⁶⁸⁸) (Kim et al., 2012) macrochaeta \| ectopic (with pum^Msc) (Kim et al., 2012) metathoracic tergum (with pum⁷) (Kim et al., 2012) metathoracic tergum (with pum⁰¹⁶⁸⁸) (Kim et al., 2012) metathoracic tergum (with pum^Msc) (Kim et al., 2012) wing vein \| ectopic (with pum¹) (Kim et al., 2012) wing vein \| ectopic (with pum⁰¹⁶⁸⁸) (Kim et al., 2012) wing vein \| ectopic (with pum^Msc) (Kim et al., 2012)
Detailed Description
	Statement Reference Trans-heterozygotes of pum[1]/pum[3] display extra wing veins. Trans-heterozygotes of pum[3]/pum[01688] display extra wing veins and extra macrochaetae on their notum. The penetrance of the notum phenotype is incomplete. Trans-heterozygotes of pum[3]/pum[Msc] display extra wing veins and extra macrochaetae on their notum. The penetrance of the phenotypes is incomplete. The notum of pum[7]/pum[3] escapers display extra macrochaetae. The penetrance of the notum phenotype is incomplete. (Kim et al., 2012)
External Data
Linkouts
Interactions
Phenotypic Class
NOT Enhancer of
Statement Reference pum³ is a non-enhancer of neuroanatomy defective phenotype of Hsap\ATXN8OS^{CTG112.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Mutsuddi et al., 2004)
NOT Suppressor of
Statement Reference pum³ is a non-suppressor of neuroanatomy defective phenotype of Hsap\ATXN8OS^{CTG112.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Mutsuddi et al., 2004)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 2 )
Bloomington	3335 th¹ st¹ kni^ri-1 p^p pum³ e¹ tll¹/TM3, Sb¹
Kyoto	106986 th¹ st¹ kni^ri-1 p^p pum³ e¹ tll¹/TM3, Sb¹
Notes on Origin
Discoverer
	Recovered on the basis of failure to complement the maternal phenotype. (Lindsley and Zimm, 1992)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	pum³ (Kim et al., 2012) pum^ET3 (Sonoda and Wharton, 1999, Murata and Wharton, 1995, Tearle and Nusslein-Volhard, 1987, Barker et al., 1992, Kadyrova et al., 2007) pum^TE3 (Lin and Spradling, 1997)
Name Synonym
Secondary FlyBase IDs

References ( 10 )
Research paper	Kim et al., 2012, PLoS ONE 7(4): e34016 Negative Regulation of EGFR/MAPK Pathway by Pumilio in Drosophila melanogaster. [FBrf0218126] Kadyrova et al., 2007, Development 134(8): 1519--1527 Translational control of maternal Cyclin B mRNA by Nanos in the Drosophila germline. [FBrf0194692] Mutsuddi et al., 2004, Curr. Biol. 14(4): 302--308 The spinocerebellar ataxia 8 noncoding RNA causes neurodegeneration and associates with staufen in Drosophila. [FBrf0174476] Schweers et al., 2002, Genetics 161(3): 1177--1185 The Drosophila melanogaster translational repressor pumilio regulates neuronal excitability. [FBrf0151333] Sonoda and Wharton, 1999, Genes Dev. 13(20): 2704--2712 Recruitment of nanos to hunchback mRNA by pumilio. [FBrf0112045] Lin and Spradling, 1997, Development 124(12): 2463--2476 A novel group of pumilio mutations affects the asymmetric division of germline stem cells in the Drosophila ovary. [FBrf0095585] Murata and Wharton, 1995, Cell 80(5): 747--756 Binding of pumilio to maternal hunchback mRNA is required for posterior patterning in Drosophila embryos. [FBrf0080271] Barker et al., 1992, Genes Dev. 6: 2312--2326 Pumilio is essential for function but not for distribution of the Drosophila abdominal determinant Nanos. [FBrf0056126]
Stock list	Tearle and Nusslein-Volhard, 1987, D. I. S. 66: 209--269 Tubingen mutants and stock list. [FBrf0045941]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]

Allele Dmel\pum3

Allele Dmel\pum³