Allele Dmel\R¹

General Information
Symbol	Dmel\R¹	Species	D. melanogaster
Name		FlyBase ID	FBal0014168
Feature type	allele	Created / Updated	2006-08-22/2006-08-22
Associated gene	Dmel\R

Allele class	neomorph
Mutagen
Nature of the Allele
Allele class	neomorph (Hariharan et al., 1991)
Mutagen
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: F157L. Nucleotide substitution: C?G. (Hariharan et al., 1991)
Assay mode
Cytology
Phenotypic Data
Phenotypic Class
	viable (Li et al., 1997) visible \| dominant (Hariharan et al., 1991, Li et al., 1997)
Phenotype Manifest In
	secondary pigment cell (Hariharan et al., 1991) photoreceptor cell R1 (Hariharan et al., 1991) photoreceptor cell R2 (Hariharan et al., 1991) photoreceptor cell R3 (Hariharan et al., 1991) photoreceptor cell R4 (Hariharan et al., 1991) photoreceptor cell R5 (Hariharan et al., 1991) photoreceptor cell R6 (Hariharan et al., 1991) photoreceptor cell R7 (Hariharan et al., 1991) photoreceptor cell R8 (Hariharan et al., 1991) eye (Asha et al., 1999) eye photoreceptor cell (Li et al., 1997)
Detailed Description
	Statement Reference Eyes of R/+ rough, have some large dark facets. Photoreceptor cell 7 frequently absent (Carthew). Male genitalia frequently rotated and male sometimes sterile; viability about 80% wild type. wings spread. Thorax short; acrostichal hairs deranged, some missing; eyes small. homozygous female-fertile. RK1. homozygous semi-lethal Heterozygotes have rough eyes due to disruption of the normal ommatidial array. Most ommatidia have the R7 cell missing, others an outer photoreceptor missing, ommatidia may be fused and their orientation with respect to each other is random. Secondary pigment cells are also missing. Homozygotes have rough eyes and reduced viability. R¹/Df(3L)R-E heterozygotes have a rougher eye phenotype than R¹ heterozygotes. (Hariharan et al., 1991) Roughened external eye morphology, internally most facets are missing R7 and some are missing outer cells. Analysis of mosaic facets reveals a strong requirement of R in R7 and a weaker requirement in R6. (Li et al., 1997) Rough eye phenotype. (Asha et al., 1999)
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement Reference R¹ has phenotype, enhanceable by dap² (de Nooij et al., 1996) R¹ has phenotype, enhanceable by dap³ (de Nooij et al., 1996)
NOT suppressed by
Statement Reference R¹ has phenotype, non-suppressible by su(Hw)² (Lindsley and Grell, 1968)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	R^PIE-6 (Mahoney et al., 2006)
Comments
Stocks ( 9 )
Bloomington	821 In(3L)P, mot-36e¹/R¹ 630 rho^ve-1 R¹/In(3L)P, gm¹ 1689 R¹ D¹ red¹ Sb¹/TM6 563 Df(3L)Ly, R¹ sens^Ly-1/In(3L)P, gm¹ 4463 In(3L)D, rho^ve-1 R¹ D³ st¹ Ubx¹ e⁴ Pr¹ ca¹/In(3R)P, Dfd¹ ca¹
Kyoto	106295 LS(3)P10, R¹//DS(3)P10, Ki⁺ 105982 R¹ Ly¹/In(3L)P, gm¹ 106454 R¹ D¹ red¹ Sb¹/TM6 107754 In(3L)D, rho^ve-1 R¹ D³ st¹ Ubx¹ e⁴ Pr¹ ca¹/In(3R)P, Dfd¹ ca¹
Notes on Origin
Discoverer	E. M. Wallace, Sep. 1935.

Comments
	Used as starting point to generate deletions in 62B to 62D region. (Sliter et al., 1989) Mutation is not a simple hypermorph or hypomorph. The protein does provide some wild type activity and also antagonises the wild-type function in some manner. (Li et al., 1997)
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	R¹ (Mahoney et al., 2006) Rap1^R (Li et al., 1997) unnamed (Asha et al., 1999)
Name Synonym
Secondary FlyBase IDs

References ( 9 )
Research paper	Mahoney et al., 2006, Genetics 172(4): 2309--2324 Presenilin-based genetic screens in Drosophila melanogaster identify novel Notch pathway modifiers. [FBrf0190744] Fanara et al., 2002, Genetics 162(3): 1321--1328 Vanaso is a candidate quantitative trait gene for Drosophila olfactory behavior. [FBrf0155481] Asha et al., 1999, EMBO J. 18(3): 605--615 The Rap1 GTPase functions as a regulator of morphogenesis in vivo. [FBrf0106166] Li et al., 1997, Proc. Natl. Acad. Sci. USA 94(23): 12515--12520 Genetic interactions with rap1 and ras1 reveal a second function for the fat facets deubiquitinating enzyme in Drosophila eye development. [FBrf0099363] de Nooij et al., 1996, Cell 87(7): 1237--1247 A cyclin-dependent kinase inhibitor, dacapo, is necessary for timely exit from the cell cycle during Drosophila embryogenesis. [FBrf0091210] Hariharan et al., 1991, Cell 67(23): 717--722 The Drosophila roughened mutation: activation of a rap homolog disrupts eye development and interferes with cell determination. [FBrf0053393] Sliter et al., 1989, Genetics 123: 327--336 The genetics of the Dras3-Roughened-ecdysoneless chromosomal region (62B3-4 to 62D3-4) in Drosophila melanogaster: analysis of recessive lethal mutations. [FBrf0049893]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905] Lindsley and Grell, 1968, Publs Carnegie Instn 627: 469pp Genetic variations of Drosophila melanogaster. [FBrf0020044]

Allele Dmel\R1

Allele Dmel\R¹