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General Information
Symbol
Dmel\Rap11
Species
D. melanogaster
Name
FlyBase ID
FBal0014168
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    point mutation
    Nucleotide change:

    C1860741G

    Amino acid change:

    F157L | Rap1-PA; F157L | Rap1-PB; F157L | Rap1-PC

    Reported amino acid change:

    F157L

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Amino acid replacement: F157L. Nucleotide substitution: C?G.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Rough eye phenotype.

    Roughened external eye morphology, internally most facets are missing R7 and some are missing outer cells. Analysis of mosaic facets reveals a strong requirement of R in R7 and a weaker requirement in R6.

    Heterozygotes have rough eyes due to disruption of the normal ommatidial array. Most ommatidia have the R7 cell missing, others an outer photoreceptor missing, ommatidia may be fused and their orientation with respect to each other is random. Secondary pigment cells are also missing. Homozygotes have rough eyes and reduced viability. R1/Df(3L)R-E heterozygotes have a rougher eye phenotype than R1 heterozygotes.

    Eyes of R/+ rough, have some large dark facets. Photoreceptor cell 7 frequently absent (Carthew). Male genitalia frequently rotated and male sometimes sterile; viability about 80% wild type. wings spread. Thorax short; acrostichal hairs deranged, some missing; eyes small. homozygous female-fertile. RK1. homozygous semi-lethal

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Enhanced by
    Statement
    Reference

    Rap11 has phenotype, enhanceable by dap2

    Rap11 has phenotype, enhanceable by dap3

    NOT suppressed by
    Statement
    Reference

    Rap11 has phenotype, non-suppressible by su(Hw)2

    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Fails to complement
    Comments
    Images (1)
    Stocks (6)
    Notes on Origin
    Discoverer

    E. M. Wallace, Sep. 1935.

    Comments
    Comments

    Used as starting point to generate deletions in 62B to 62D region.

    Mutation is not a simple hypermorph or hypomorph. The protein does provide some wild type activity and also antagonises the wild-type function in some manner.

    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (3)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (9)