|Feature type||allele||Associated gene||Dmel\rad|
|Also Known As||rsh1|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Predicted to result in a truncated rad protein that is lacking the C-terminal 64 amino acid residues.
Nucleotide substitution: C?T.
Amino acid replacement: Q?@.
|Phenotype Manifest In|
Compared with wild-type, rad mutants display an increase in varicosity number and a decrease in innervation length, resulting in a compact innervation pattern at the third instar larval neuromuscular junction.
Three-hour memory impairment after cold-induced anesthesia is reduced further in rad mutants. Reducing 5HT levels by pCPA feeding has no effect in rad mutants.
Extinction learning in rad mutants, with either 10 or 30 cycles of training is no different from wild-type controls.
rad flies exhibit a reduced sugar response compared to wild-type Canton-S flies.
Mutant pupae show bradycardia. At every temperature tested, the mutant heart rate is significantly lower than that of wild type. This strain is insensitive to both serotonin and norepinephrine.
rad1 flies can learn better than wild-type controls in a standard training procedure. Memory retention is not significantly affected by the rad1 mutation.
In wild-type animals, increasing the density at which larvae are reared results in an increase in the volume of the calyx in the adult brain. This plasticity is still seen in rad1 mutants.
Anesthesia resistant memory is disrupted. One day retention after massed training is zero, and after spaced training is subnormal. rad1 mutants fed cycloheximide showed zero 1 day retention after spaced training. However, 2-7 day retention after spaced training is similar to that of wild type flies.
Individuals learn normally but display abnormally rapid memory decay after training in the olfactory discrimination test of Tully and Quinn (Tully, J. Comp. Physiol. A 157: 263). Memory loss decays to zero.
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
Memory assayed in a classical Pavlovian conditioning procedure for odor-avoidance.
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 5 )|
|Secondary FlyBase IDs|
|References ( 14 )|