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General Information
Symbol
Dmel\rb1
Species
D. melanogaster
Name
FlyBase ID
FBal0014434
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
ruby1
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference
    Mutant flies show a significant decrease in ommochrome and drosopterin pigment levels compared to wild type.
    Mutant flies have reduced red pigment in the eye compared to controls.
    Mutant males have a shortened adult life span compared to controls, with a mean life span of 31.57 days at 25o.
    Eye colour: the drosopterin (red pigment) content of rb1 flies is reduced to 25% of wild type. Eye colour: the drosopterin (red pigment) content of g1 rb1 double mutant flies is reduced to 18% of wild type. Eye colour: the xanthommatin (brown pigment) content of rb1 flies is reduced to 58% of wild type. Eye colour: the xanthommatin (brown pigment) content of g1 rb1 double mutant flies is reduced to 41% of wild type.
    Examination of mutant eyes reveal a dramatic decrease in the number of electron dense pigment granules seen surrounding groups of photoreceptor cells. Examination of retinula cells from rb1 mutants reveals normal neuronal anatomy, including normal cytoplasmic synaptic vesicles (SVs). In an assay for larval motility, rb1 mutants performed as well as wild-type larvae. In locomotor assays testing olfactory response to propionic acid, rb1 mutants perform significantly less well than wild-type larvae.
    Malpighian tubule colour: pale yellow.
    Development of pigment autonomous in eye discs transplanted into wild-type hosts.
    RK1. Eye colour: clear ruby. Ocellus colour: colourless. Testis colour: colourless.
    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Enhanced by
    Statement
    Reference
    Enhancer of
    Statement
    Reference
    rb1 is an enhancer of visible phenotype of Scer\GAL4GMR.PF, aosGD16463
    rb1 is an enhancer of eye color defective phenotype of Blos1ex2
    Other
    Statement
    Reference
    Phenotype Manifest In
    NOT suppressed by
    Statement
    Reference
    rb1 has phenotype, non-suppressible by su(Hw)2
    Enhancer of
    Statement
    Reference
    rb1 is an enhancer of eye phenotype of Scer\GAL4GMR.PF, aosGD16463
    Other
    Statement
    Reference
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    The mispatterning of the eye caused by expression of aosGD16463 under the control of Scer\GAL4GMR.PF is modestly enhanced in a rb1 mutant background.
    Expression of auxScer\UAS.cHa under the control of Scer\GAL4GMR.PF enhances the loss of red eye pigment that is seen in rb1 flies.
    The reduction in red pigment in the eye seen in rb1 blos1ex2 double mutants is more severe than that seen in either single mutant.
    rb1 is a complex modifier of the eye phenotype caused by expression of bchsEP2299 under the control of Scer\GAL4GMR.PF.
    The level of pteridine eye pigments in rb1 ; ltd1 double mutant flies are significantly lower than that of the corresponding single mutants.
    Eye colour: nearly white, with ltd1. Pale eye color due to the absence of pteridines and brown pigment.
    Eye colour: white, with wa. Eye colour: orange, with st1. Eye colour: brownish red, with bw1.
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (2)
    Stocks (22)
    Notes on Origin
    Discoverer
    Bridges, 18th Oct. 1914.
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    References (20)