|Feature type||allele||Associated gene||Dmel\rb|
|Also Known As||ruby1|
What does this section display?
This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
|All updates||Click here to see a list of all updates to this record from FB2010_08 and on.|
|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Phenotype Manifest In|
Mutant flies show a significant decrease in ommochrome and drosopterin pigment levels compared to wild type.
Mutant flies have reduced red pigment in the eye compared to controls.
Mutant males have a shortened adult life span compared to controls, with a mean life span of 31.57 days at 25o.
Eye colour: the drosopterin (red pigment) content of rb1 flies is reduced to 25% of wild type. Eye colour: the drosopterin (red pigment) content of g1 rb1 double mutant flies is reduced to 18% of wild type. Eye colour: the xanthommatin (brown pigment) content of rb1 flies is reduced to 58% of wild type. Eye colour: the xanthommatin (brown pigment) content of g1 rb1 double mutant flies is reduced to 41% of wild type.
Examination of mutant eyes reveal a dramatic decrease in the number of electron dense pigment granules seen surrounding groups of photoreceptor cells. Examination of retinula cells from rb1 mutants reveals normal neuronal anatomy, including normal cytoplasmic synaptic vesicles (SVs). In an assay for larval motility, rb1 mutants performed as well as wild-type larvae. In locomotor assays testing olfactory response to propionic acid, rb1 mutants perform significantly less well than wild-type larvae.
Malpighian tubule colour: pale yellow.
Development of pigment autonomous in eye discs transplanted into wild-type hosts.
RK1. Eye colour: clear ruby. Ocellus colour: colourless. Testis colour: colourless.
rb1 has eye color defective phenotype, enhanceable by auxScer\UAS.cHa/Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
|Phenotype Manifest In|
|NOT suppressed by|
The mispatterning of the eye caused by expression of aos[GD16463] under the control of Scer\GAL4[GMR.PF] is modestly enhanced in a rb mutant background.
The reduction in red pigment in the eye seen in rb blos1[ex2] double mutants is more severe than that seen in either single mutant.
Expression of aux[Scer\UAS.cHa] under the control of Scer\GAL4[GMR.PF] enhances the loss of red eye pigment that is seen in rb flies.
rb1 is a complex modifier of the eye phenotype caused by expression of bchsEP2299 under the control of Scer\GAL4GMR.PF.
The level of pteridine eye pigments in rb1 ; ltd1 double mutant flies are significantly lower than that of the corresponding single mutants.
Eye colour: nearly white, with ltd1. Pale eye color due to the absence of pteridines and brown pigment.
|Complementation & Rescue Data|
|Stocks ( 23 )|
|Notes on Origin|
Bridges, 18th Oct. 1914.
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 3 )|
|Secondary FlyBase IDs|
|References ( 19 )|
|Personal communication to FlyBase|