FB2025_01 , released February 20, 2025
Allele: Dmel\rb1
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General Information
Symbol
Dmel\rb1
Species
D. melanogaster
Name
FlyBase ID
FBal0014434
Feature type
allele
Associated gene
Dmel\rb
Associated Insertion(s)
Carried in Construct
Also Known As
ruby1
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        exacerbates  Hermansky-Pudlak syndrome
        modeled by Blos1ex2
        (Cheli et al., 2010)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Mutant flies show a significant decrease in ommochrome and drosopterin pigment levels compared to wild type.

        (Harris et al., 2011)

        Mutant flies have reduced red pigment in the eye compared to controls.

        (Cheli et al., 2010, Cheli et al., 2010)

        Mutant males have a shortened adult life span compared to controls, with a mean life span of 31.57 days at 25o.

        (Simonsen et al., 2007)

        Eye colour: the drosopterin (red pigment) content of rb1 flies is reduced to 25% of wild type. Eye colour: the drosopterin (red pigment) content of g1 rb1 double mutant flies is reduced to 18% of wild type. Eye colour: the xanthommatin (brown pigment) content of rb1 flies is reduced to 58% of wild type. Eye colour: the xanthommatin (brown pigment) content of g1 rb1 double mutant flies is reduced to 41% of wild type.

        (Kretzschmar et al., 2000)

        Examination of mutant eyes reveal a dramatic decrease in the number of electron dense pigment granules seen surrounding groups of photoreceptor cells. Examination of retinula cells from rb1 mutants reveals normal neuronal anatomy, including normal cytoplasmic synaptic vesicles (SVs). In an assay for larval motility, rb1 mutants performed as well as wild-type larvae. In locomotor assays testing olfactory response to propionic acid, rb1 mutants perform significantly less well than wild-type larvae.

        (Mullins et al., 2000)

        Malpighian tubule colour: pale yellow.

        (Beadle, 1937)

        Development of pigment autonomous in eye discs transplanted into wild-type hosts.

        (Beadle and Ephrussi, 1936)

        RK1. Eye colour: clear ruby. Ocellus colour: colourless. Testis colour: colourless.

        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhanced by
        Statement
        Reference

        rb1 has abnormal eye color phenotype, enhanceable by auxUAS.cHa/Scer\GAL4GMR.PF

        (Cheli et al., 2010)

        rb1 has abnormal eye color phenotype, enhanceable by Blos1ex2

        (Cheli et al., 2010)
        Enhancer of
        Statement
        Reference

        rb1 is an enhancer of visible phenotype of Scer\GAL4GMR.PF, aosGD16463

        (Harris et al., 2011)

        rb1 is an enhancer of abnormal eye color phenotype of Blos1ex2

        (Cheli et al., 2010)
        Other
        Statement
        Reference

        Rab32ltd-1, rb1 has abnormal eye color phenotype

        (Silva and Mensua, 1985)
        Phenotype Manifest In
        NOT suppressed by
        Statement
        Reference

        rb1 has phenotype, non-suppressible by su(Hw)2

        (Lindsley and Grell, 1968)
        Enhancer of
        Statement
        Reference

        rb1 is an enhancer of eye phenotype of Scer\GAL4GMR.PF, aosGD16463

        (Harris et al., 2011)
        Other
        Statement
        Reference

        Rab32ltd-1, rb1 has pigment cell phenotype

        (Silva and Mensua, 1985)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The mispatterning of the eye caused by expression of aosGD16463 under the control of Scer\GAL4GMR.PF is modestly enhanced in a rb1 mutant background.

        (Harris et al., 2011)

        Expression of auxScer\UAS.cHa under the control of Scer\GAL4GMR.PF enhances the loss of red eye pigment that is seen in rb1 flies.

        (Cheli et al., 2010)

        The reduction in red pigment in the eye seen in rb1 blos1ex2 double mutants is more severe than that seen in either single mutant.

        (Cheli et al., 2010)

        rb1 is a complex modifier of the eye phenotype caused by expression of bchsEP2299 under the control of Scer\GAL4GMR.PF.

        (Simonsen et al., 2007)

        The level of pteridine eye pigments in rb1 ; ltd1 double mutant flies are significantly lower than that of the corresponding single mutants.

        (Ma et al., 2004)

        Eye colour: nearly white, with ltd1. Pale eye color due to the absence of pteridines and brown pigment.

        (Silva and Mensua, 1985)

        Eye colour: white, with wa. Eye colour: orange, with st1. Eye colour: brownish red, with bw1.

        (Mainx, 1938)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (2)
        Stocks (21)
        Notes on Origin
        Discoverer

        Bridges, 18th Oct. 1914.

        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        References (21)