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General Information
Symbol
Dmel\brrbp-2
Species
D. melanogaster
Name
FlyBase ID
FBal0014442
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
rbp2, rbpt132
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

100% of brrbp-2/brnpr-3 larvae are able to pupate, but ~15% die as early pupae. 80% of these survive to late pharate adult stage, with ~20% failing to eclose. brrbp-2 females show slightly reduced levels of oviposition compared to wild-type females. brrbp-2 flies show the same susceptibility to methoprene as wild-type flies.

Eggs dissected from homozygous brrbp-2 mothers have shortened dorsal appendages. brrbp-2/brnpr-6 females live for two days before dying having laid no eggs. Their ovaries are not completely developed, and the few late stage oocytes that were formed had no appendages.

DVM number is reduced (a deficit in thoracic muscle precursors), as is the flight performance.

Heterozygotes with brrbp-5 display reduced mechanosensory bristles on the maxillary palps and indentations on the surface of the eye.

Morphological abnormalities: 15--100% penetrance of bristle abnormalities under T(1;2)dorvar7 variegation.

Reduced bristle number on palpus, faded wings and swollen abdomen. Rare survivors when heterozygous with Df(1)RA19, lethal phase is after the formation of imaginal organs.

Homozygotes exhibit reduction of the palpal bristles. brrbp-2/brnpr-5 and brrbp-2/brnpr-6 combination is lethal, rare adult escapers show a reduction of the bristle number on the palpus. Heterozygotes with Df(1)br25 have normal viability and reduced bristle number on the palpus.

Homozygotes and males survive with fewer than normal bristles on the palpus; when raised at 29oC, females exhibit faded wings and swollen abdomens; when raised at 18oC males have faded wings. brrbp-2/Df(1)RA19 females virtually lethal; females carrying brrbp-2 and any of the other 'rbp' alleles are completely viable when reared at 18oC, but at higher temperatures most die and escapers have reduced bristles on the palpus, shortened bristles on the scutellum, shrivelled or swollen abdomen shrivelled wings and eyes with crumpled surface.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Enhancer of
Statement
Reference

brrbp-2 is an enhancer of visible phenotype of Met27

brrbp-2 is an enhancer of visible phenotype of MetW3

Other
Phenotype Manifest In
Enhanced by
Statement
Reference

brrbp-2 has ovary phenotype, enhanceable by Met27/Met27

Enhancer of
Statement
Reference

brrbp-2/brrbp-2 is an enhancer of ovary phenotype of Met27

brrbp-2 is an enhancer of eye phenotype of Met27

brrbp-2 is an enhancer of eye phenotype of MetW3

Additional Comments
Genetic Interactions
Statement
Reference

The lethality is enhanced in brrbp-2/brnpr-3 Rst(1)JH3/Rst(1)JH3 double mutants compared to brrbp-2/brnpr-3 mutants, with no flies surviving beyond the pupal stage. While 86% of brrbp-2/brrbp-2, Rst(1)JH27/+ flies survive to adulthood, <2% of brrbp-2/brrbp-2, Rst(1)JH27/Rst(1)JH27 flies survive this far, with most dying during the pharate adult stage. brrbp-2/brrbp-1, Rst(1)JH27/Rst(1)JH27 flies are also prepupal/early pupal lethals. Expression of the Rst(1)JH+tSt-H.hs transgene can rescue the lethality of brrbp-2/brrbp-2, Rst(1)JH27/Rst(1)JH27 or brrbp-2/brrbp-1, Rst(1)JH27/Rst(1)JH27 flies. brrbp-2/brrbp-2, Rst(1)JH27/Rst(1)JH27 female escapers show strong reductions in oogenesis.

The expressivity of the defective eye phenotype seen in MetW3 and Met27 flies is increased by brrbp-2.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially complements
Comments

Complementation is based on lethality.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (13)