FB2025_01 , released February 20, 2025
Allele: Dmel\rdgBota1
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General Information
Symbol
Dmel\rdgBota1
Species
D. melanogaster
Name
FlyBase ID
FBal0014502
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Abnormal olfactory behaviour, but recovery kinetic is not significantly delayed and defective response in olfactory jump assay that is reduced further in the dark. Light induced degeneration of photoreceptor cells. No EAG defect.

Homozygotes show abnormal trap-entry with food medium or ethyl acetate as the stimulus, and a defective response (to ethyl acetate, propionic acid or benzaldehyde) in a chemosensory jump assay. Retinal depolarisation is defective in homozygotes; the "on" and "off" transients are missing. Giant fibre pathway physiology appears normals.

Poor odor responses in tests involving an olfactory trap; entry into such traps was subnormal when odorant was food medium or ethyl acetate. Phenotype also subnormal in odor-induced jump responses (using ethyl acetate, propionic acid, or benzaldehyde as stimulant). Electroretinogram abnormal; very weak light induced depolarization and no light-on or light-off transients.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement
Reference

rdgBota1 has ommatidium phenotype, suppressible by trp1

NOT suppressed by
Statement
Reference

rdgBota1 has eye photoreceptor cell phenotype, non-suppressible by inaC2

rdgBota1 has ommatidium phenotype, non-suppressible by inaC2

Additional Comments
Genetic Interactions
Statement
Reference

inaC2 does not significantly alter the deep pseudopupil loss of rdgBota1 flies and fails to suppress the photoreceptor degeneration and ommatidial disorganisation seen in these flies at 6 days after eclosion. trp1 slows the initiation of deep pseudopupil loss of rdgBota1 flies and dramatically suppresses photoreceptor degeneration and ommatidial disorganisation in these flies.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

The olfactory and ERG phenotypes of rdgBota1 cosegregate.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
rdgBota1
Name Synonyms
olfactory-trap-abnormal-1
Secondary FlyBase IDs
    References (7)