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Allele Dmel\kni^ri-1

General Information
Symbol	Dmel\kniri-1	Species	D. melanogaster
Name		FlyBase ID	FBal0014568
Feature type	allele	Created / Updated	2006-08-22/2006-08-22
Associated gene	Dmel\kni
Allele class
Mutagen	spontaneous
Nature of the Allele
Allele class
Mutagen	spontaneous
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype
Nature of the lesion	Statement Reference 252bp deletion within fragment "E" of the kni putative upstream regulatory sequences. (Lunde et al., 2003)
Assay mode
Carried on aberration	TM3-P{Δ2-3} (FlyBase Curators, 2006-) TM3 (FlyBase Curators, 2006-, Lindsley and Zimm, 1992, Bloomington Drosophila Stock Center, 1998.5.16) TM3βT8 (FlyBase Curators, 2006-) TM3-HBL1.1 (FlyBase Curators, 2006-) TM3-vKb (FlyBase Curators, 2006-) TM3-vKc (FlyBase Curators, 2006-) TM3-vCd (FlyBase Curators, 2006-) TM3-HShid (FlyBase Curators, 2006-) TM3-DZ (FlyBase Curators, 2006-) TM3-lacZ-hg (FlyBase Curators, 2006-) TM3-vSb (FlyBase Curators, 2006-) TM3-vCe (FlyBase Curators, 2006-) TM3-vKd (FlyBase Curators, 2006-) TM3-Pw+-lacZ (FlyBase Curators, 2006-) TM3-ftz-lacZ (FlyBase Curators, 2006-) TM3-vTa (FlyBase Curators, 2006-) TM3-vMa (FlyBase Curators, 2006-) TM3-vMb (FlyBase Curators, 2006-) TM3-vMc (FlyBase Curators, 2006-) TM3-vMd (FlyBase Curators, 2006-) TM3-P{ftz/lacZ} (FlyBase Curators, 2006-) TM3-vGa (FlyBase Curators, 2006-) TM3-vSa (FlyBase Curators, 2006-) TM3-SC143 (FlyBase Curators, 2006-) TM3-4 (FlyBase Curators, 2006-) TM3-5 (FlyBase Curators, 2006-) TM3-P{UAS-Dl.DN} (FlyBase Curators, 2006-) TM3-3-10 (FlyBase Curators, 2006-) TM3-GMRargos (FlyBase Curators, 2006-) TM3-GTY (FlyBase Curators, 2006-) TM3-STY (FlyBase Curators, 2006-) TM3-P{ey-FLP.B}3.1 (FlyBase Curators, 2006-) TM3-TCAG (FlyBase Curators, 2006-) TM3-TCAGB (FlyBase Curators, 2006-) TM3-TTG (FlyBase Curators, 2006-) TM3-vCa (FlyBase Curators, 2006-) TM1 (FlyBase Curators, 2006-, Lindsley and Zimm, 1992, Bloomington Drosophila Stock Center, 1998.5.16) C(3L)RM-P2   TM3-P{ftz/lacC}SC1 (FlyBase Curators, 2006-) TM1-mr (FlyBase Curators, 2006-) TM3-krS (FlyBase Curators, 2006-) TM1-red (FlyBase Curators, 2006-) TM1-Su(ss)2 (FlyBase Curators, 2006-) TM3-T2B (FlyBase Curators, 2006-) CyO-TM3-GFP (FlyBase Curators, 2006-, Rudolph et al., 1999) C(3L)RM-P3   Dp(3;3)Cam36 (Roote, 2000.3.14, Roote, 2004.6.24) TM3-rSS (FlyBase Curators, 2006-) TM3-St (FlyBase Curators, 2006-) TM3-ca (FlyBase Curators, 2006-) TM3-Sr (FlyBase Curators, 2006-) TM3-vSd (FlyBase Curators, 2006-) TM3-AS (FlyBase Curators, 2006-) TM3-Sb (FlyBase Curators, 2006-) TM3-ry (FlyBase Curators, 2006-) TM3-D6 (FlyBase Curators, 2006-) TM3-ISPSAS (FlyBase Curators, 2006-) TM3-rS (FlyBase Curators, 2006-) TM3-vCb (FlyBase Curators, 2006-) TM3-P{sevRas1.V12}FK2 (FlyBase Curators, 2006-) TM3-vMe (FlyBase Curators, 2006-) TM3-SbSer (FlyBase Curators, 2006-) TM3-rsuS (FlyBase Curators, 2006-) TM3-vSc (FlyBase Curators, 2006-) TM3-pAct-GFP (FlyBase Curators, 2006-, Reichhart and Ferrandon, 1998.6.8, Reichhart and Ferrandon, 1998) TM3-GFP (FlyBase Curators, 2006-, Rudolph et al., 1999) TM3-P{ftz-lacZ.ry+}TM3 (FlyBase Curators, 2006-) TM3-P{GAL4-Hsp70.PB}TR2,P{UAS-GFP.Y}TR2 (FlyBase Curators, 2006-) TM1-rD (FlyBase Curators, 2006-) TM3-HoP3B (FlyBase Curators, 2006-) TM3-UbxD105.17 (FlyBase Curators, 2006-) TM3-ArSS (FlyBase Curators, 2006-) TM3-P{UAS-y.C}MC2 (FlyBase Curators, 2006-) TM1-pp (FlyBase Curators, 2006-) TM3-P{UAS-Dl.DN}TJ1 (FlyBase Curators, 2006-) TM1-st (FlyBase Curators, 2006-) TM3-rrSS (FlyBase Curators, 2006-) In(3LR)sep   TM3-p+Sb1 (FlyBase Curators, 2006-) TM3-P{35UZ}2 (FlyBase Curators, 2006-) TM1-jv (FlyBase Curators, 2006-) TM3-Thb8 (FlyBase Curators, 2006-) TM3-vKa (FlyBase Curators, 2006-) TM3-mwh2-ru1 (FlyBase Curators, 2006-) TM3-Ser (FlyBase Curators, 2006-)
Cytology
Phenotypic Data
Phenotypic Class
	visible (Lunde et al., 2003, ) visible | recessive (Lunde et al., 1998)
Phenotype Manifest In
	wing vein L2 (Lunde et al., 2003, Lunde et al., 1998) wing
Detailed Description
	Statement Reference RK1. Vein L2 interrupted. Wings slightly warped and blunt.   Homozygous flies show loss of wing vein L2. The L2 wing vein truncation phenotype is rescued with high penetrance by kniScer\UAS.cLa expressed under the control of Scer\GAL4Bx-MS1096 or by kniEP, but the rescued vein is consistently displaced anteriorly relative to the normal position of the L2 vein. kniri-1/In(3L)riXT101 flies have a strong "ri" phenotype. (Lunde et al., 1998) Homozygous adults have a severely truncated L2 wing vein. (Lunde et al., 2003)
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference kniri-1 has visible phenotype, suppressible by egScer\UAS.cDa/Scer\GAL4kni.L2 (Lunde et al., 2003) kniri-1 has visible phenotype, suppressible by rhoScer\UAS.cBa/Scer\GAL4kni.L2 (Lunde et al., 2003) kniri-1 has visible phenotype, suppressible by knrlScer\UAS.cLa/Scer\GAL4kni.L2 (Lunde et al., 2003)
Suppressor of
Statement Reference kniri-1 is a suppressor | partially of visible | recessive phenotype of salm1 (Lunde et al., 1998)
Phenotype Manifest In
Suppressed by
Statement Reference kniri-1 has wing vein L2 phenotype, suppressible by egScer\UAS.cDa/Scer\GAL4kni.L2 (Lunde et al., 2003) kniri-1 has wing vein L2 phenotype, suppressible by rhoScer\UAS.cBa/Scer\GAL4kni.L2 (Lunde et al., 2003) kniri-1 has wing vein L2 phenotype, suppressible by knrlScer\UAS.cLa/Scer\GAL4kni.L2 (Lunde et al., 2003)
NOT Enhancer of
Statement Reference kni[+]/kniri-1 is a non-enhancer of wing vein | ectopic phenotype of Snr1E1 (Marenda et al., 2004)
Suppressor of
Statement Reference kniri-1 is a suppressor of wing vein L2 | ectopic phenotype of salm1 (Lunde et al., 1998)
NOT Suppressor of
Statement Reference kni[+]/kniri-1 is a non-suppressor of wing vein | ectopic phenotype of Snr1E1 (Marenda et al., 2004) kniri-1 is a non-suppressor of dorsal triple row | ectopic phenotype of salm1 (Lunde et al., 1998) kniri-1 is a non-suppressor of medial triple row | ectopic phenotype of salm1 (Lunde et al., 1998) kniri-1 is a non-suppressor of ventral triple row | ectopic phenotype of salm1 (Lunde et al., 1998)
Additional Comments
Genetic Interactions
Statement Reference Homozygous salm1 clones between veins L2 and L3 have an ectopic vein L2 fork running within and along the clone boundary. These ectopic L2 forks are not induced by homozygous salm1 clones in a kniri-1 background. Homozygous salm1 clones which intersect the wing margin are associated with ectopic islands of triple row bristles. This phenotype is induced by salm1 clones in a kniri-1 background. (Lunde et al., 1998) Expression of knrlScer\UAS.cLa under the control of Scer\GAL4kni.L2 rescues the L2 wing vein phenotype of kniri-1 flies. Expression of rhoScer\UAS.cBa under the control of Scer\GAL4kni.L2 rescues the L2 wing vein phenotype of kniri-1 flies. Expression of egScer\UAS.cDa under the control of Scer\GAL4kni.L2 restores wing vein L2 formation in kniri-1 flies. The restored L2 vein is decorated with a line of ectopic sensory bristles (these ectopic bristles are also seen when egScer\UAS.cDa is expressed under the control of Scer\GAL4kni.L2 in a wild-type background). (Lunde et al., 2003)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	kniri-XT2 (Lunde et al., 1998)
Rescued by	kniri-1 is rescued by kniScer\UAS.cLa/Scer\GAL4kni.L2 (Lunde et al., 2003)
Partially rescued by	kniri-1 is partially rescued by kniEP (Lunde et al., 1998) kniri-1 is partially rescued by kniScer\UAS.cLa/Scer\GAL4Bx-MS1096 (Lunde et al., 1998)
Comments	kni1, kni3, kni8 and kni9 fail to complement kniri-1 when it is carried on a chromosome such as TM3 or In(3LR)LD6 that is rearranged with respect to the kni1, kni3, kni8 or kni9 mutant chromosome. kni1, kni3, kni8 and kni9 fully complement kniri-1 when the kniri-1 and kni1, kni3, kni8 or kni9 alleles are carried on non-rearranged chromosomes. (Lunde et al., 1998)
Stocks ( 386 )
Bloomington	566 kniri-1 738 kniri-1 e1 1664 kniri-1 pp 718 C(3L)RM-P3, kniri-1; C(3R)RM-P3 704 Df(3R)M35, kniri-1/TM3, Sb1 6178 kD es/TM2, kniri-1 907 Df(3R)M312, kniri-1/TM3, Sb1 1048 DNase2n1 kniri-1 pp 4773 kniri-1 ms(3)85E1 e1/TM1
Kyoto	106041 Df(3R)M35, kniri-1/TM3, Sb1 106114 Df(3R)M312, kniri-1/TM3, Sb1 101653 In(1)wm4h ; h1 kniri-1
	More stocks available...
Notes on Origin
Discoverer	Tshetverikov, 1926.
Comments
	kniri-1, kniri-92f and kniriM have the same lesion. (Lunde et al., 2003)
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	kniri1 (Matakatsu et al., 1999) kniri-1 (Christensen et al., 2008.4.15, Christensen et al., 2008.4.15) kniri[1] (Lunde et al., 2003) ri1 (Lunde et al., 2003, Biehs et al., 1998, Lunde et al., 1998, ) unnamed (Roote, 2004.6.24)
Name Synonym
Secondary FlyBase IDs
References ( 16 )
Research paper	Marenda et al., 2004, Dev. Biol. 267(2): 279--293 The Drosophila Brahma (SWI/SNF) chromatin remodeling complex exhibits cell-type specific activation and repression functions. [FBrf0174517] Lunde et al., 2003, Development 130(2): 235--248 Activation of the knirps locus links patterning to morphogenesis of the second wing vein in Drosophila. [FBrf0155705] Xue and Noll, 2002, Development 129(2): 339--346 Dual role of the Pax gene paired in accessory gland development of Drosophila. [FBrf0144833] Matakatsu et al., 1999, Development 126(23): 5207--5216 Repression of the wing vein development in Drosophila by the nuclear matrix protein Plexus. [FBrf0111969] Rudolph et al., 1999, D. I. S. 82: 99--100 New type of CyO and TM3 green balancers. [FBrf0112022] Biehs et al., 1998, Development 125(21): 4245--4257 Boundaries in the Drosophila wing imaginal disc organize vein-specific genetic programs. [FBrf0104921] Lunde et al., 1998, Development 125(21): 4145--4154 The knirps and knirps-related genes organize development of the second wing vein in Drosophila. [FBrf0104917] Reichhart and Ferrandon, 1998, D. I. S. 81: 201--202 Green balancers. [FBrf0105466]
Personal communication to FlyBase	Christensen et al., 2008.4.15, Isolation and characterization of Df(3L)BSC448. Isolation and characterization of Df(3L)BSC448. [FBrf0204483] Christensen et al., 2008.4.15, Isolation and characterization of Df(3L)BSC452. Isolation and characterization of Df(3L)BSC452. [FBrf0204487] Roote, 2004.6.24, Cam Dps. Cam Dps. [FBrf0178882] Roote, 2000.3.14, Dp(3;3)Cam's. Dp(3;3)Cam's. [FBrf0126882] Bloomington Drosophila Stock Center, 1998.5.16, balancer stuff. balancer stuff. [FBrf0102820] Reichhart and Ferrandon, 1998.6.8, Green Balancers. Green Balancers. [FBrf0102825]
FlyBase analysis	FlyBase Curators, 2006-, Balancer summary information. Balancer summary information. [FBrf0189689]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]