Allele Dmel\rl^Sem

General Information
Symbol	Dmel\rl^Sem	Species	D. melanogaster
Name	Sevenmaker	FlyBase ID	FBal0014598
Feature type	allele	Associated gene	Dmel\rl
Also Known As	Sem

Allele class	gain of function allele, hypomorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	gain of function allele (Brunner et al., 1994, Kockel et al., 1997, Karim and Rubin, 1998, Bergmann et al., 1998) hypomorphic allele - genetic evidence (Kurada and White, 1998)
Mutagen	ethyl methanesulfonate (Brunner et al., 1994)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: D334N. Amino acid 334 is located at the C-terminal end of kinase domain XI and is conserved in the different members of the MAP kinase family. (Brunner et al., 1994)
Cytology
Phenotypic Data
Phenotypic Class
	female sterile \| dominant \| partially (Lim et al., 1999) lethal \| dominant \| maternal effect (Brunner et al., 1994) neuroanatomy defective \| dominant (Koh et al., 2002) neuroanatomy defective \| larval stage (Fischer et al., 2009) visible (Morey et al., 2001, Rintelen et al., 2003, Bai et al., 2001, Luschnig et al., 2000, Baker et al., 2002, Lorenzen et al., 2001) visible \| dominant (Roch et al., 1998, Kumar et al., 2003, Brunner et al., 1994, Zeng et al., 2007, Kim et al., 2012) visual behavior defective \| dominant (Brunner et al., 1994)
Phenotype Manifest In
	bouton \| supernumerary (Koh et al., 2002) denticle belt \| maternal effect (Li et al., 2002) embryonic abdominal segment 1 \| maternal effect (Brunner et al., 1994) embryonic abdominal segment 2 \| maternal effect (Brunner et al., 1994) embryonic abdominal segment 3 \| maternal effect (Brunner et al., 1994) embryonic abdominal segment 4 \| maternal effect (Brunner et al., 1994) embryonic abdominal segment 5 \| maternal effect (Brunner et al., 1994) embryonic abdominal segment 6 \| maternal effect (Brunner et al., 1994) embryonic abdominal segment 7 \| maternal effect (Brunner et al., 1994) embryonic abdominal segment 8 \| maternal effect (Brunner et al., 1994) embryonic abdominal segment 9 \| maternal effect (Brunner et al., 1994) embryonic abdominal segment 10 \| maternal effect (Brunner et al., 1994) embryonic abdominal segment 11 \| maternal effect (Brunner et al., 1994) eye (Karim and Rubin, 1998, Morey et al., 2001, Kurada and White, 1998, Luschnig et al., 2000, Zeidler et al., 1996) eye \| maternal effect (Brunner et al., 1994) eye photoreceptor cell \| ectopic (Kockel et al., 1997) macrochaeta (Diaz-Benjumea and Hafen, 1994) midline glial cell (Bergmann et al., 2002) NMJ bouton \| larval stage (Fischer et al., 2009) ommatidium (Kumar et al., 2003, Luschnig et al., 2000) ommatidium, with rl^{GMR.T:Scer\GAL4,T:Hsim\VP16,T:Hsim\gD} (Kumar et al., 2003) ommatidium, with rl^{GMR.T:SV40\nls2,T:Scer\GAL4,T:Hsim\VP16,T:Hsim\gD} (Kumar et al., 2003) photoreceptor cell (Hou et al., 1997, Morey et al., 2001, Peverali et al., 1996) photoreceptor cell R7 (Brunner et al., 1994, Rusch and Levine, 1994) photoreceptor cell R7 \| ectopic \| maternal effect (Brunner et al., 1994) photoreceptor cell R7 \| supernumerary (Rintelen et al., 2003) pigment cell (Kurada and White, 1998) wing (Roch et al., 1998) wing vein (Diaz-Benjumea and Hafen, 1994, Rusch and Levine, 1994) wing vein \| ectopic (Karim and Rubin, 1998, Morey et al., 2001, Marenda et al., 2006, Diaz-Benjumea and Hafen, 1994, Baker et al., 2002, Lorenzen et al., 2001, Charroux et al., 2006, Angulo et al., 2004, Zeng et al., 2007, Kim et al., 2012) wing vein \| ectopic \| maternal effect (Brunner et al., 1994) wing vein \| supernumerary (Rintelen et al., 2003, Bai et al., 2001)
Detailed Description
	Statement Reference Heterozygous rl[Sem] produces extra wing vein material. (Kim et al., 2012) Absolute bouton number and bouton number per muscle area is significantly increased in heterozygous larvae compared to controls at the neuromuscular junction in segment A3 in muscle 6/7. (Fischer et al., 2009) Heterozygotes have ectopic veins in the wing. (Zeng et al., 2007) rl^Sem/+ flies have ectopic vein material in the wing. (Charroux et al., 2006) rl^Sem mutants exhibit extra wing veins. (Marenda et al., 2006) The wings of rl[Sem]/+ animals form scattered fragments of ecoptic vein tissue in intervein regions. (Angulo et al., 2004) Heterozygotes have a rough eye phenotype, which is enhanced if these flies also express rl^{GMR.T:Scer\GAL4,T:Hsim\VP16,T:Hsim\gD} or rl^{GMR.T:SV40\nls2,T:Scer\GAL4,T:Hsim\VP16,T:Hsim\gD}. (Kumar et al., 2003) rl^Sem flies have an extra wing vein phenotype. Additional R7 cells are formed in the eye. (Rintelen et al., 2003) At stage 17 rl^Sem mutant embryos have an average of 6 midline glial cells per segment (n=231), compared to 2.8 per segment in wild-type. (Bergmann et al., 2002) rl^Sem/+ mutants exhibit a significant increase in the number of synaptic boutons compared to wild-type. (Koh et al., 2002) 10.7% of embryos derived from heterozygous females have less than 4 denticle belts. (Li et al., 2002) Extra wing veins develop. (Bai et al., 2001) Heterozygous rl^Sem animals display a mild rough eye phenotype. (Morey et al., 2001) Flies carrying rl^Sem have a rough eye phenotype. (Luschnig et al., 2000) Heterozygous females show a weak dominant sterility; 10.2% of the eggs laid by these females fail to hatch and 20.0% of these nonviable embryos have defects similar to those associated with gain-of-function alleles of tor. (Lim et al., 1999) Mutants display no apparent proliferation defect. Adult have moderately rough eyes and extra wing vein material. (Karim and Rubin, 1998) Shows supernumerary pigment cells in the developing eye, due to failure of apoptosis. (Kurada and White, 1998) rl^Sem/+ shows ectopic wing vein tissue. (Roch et al., 1998) Adults exhibit a rough eye phenotype that cannot be suppressed by heterozygosity for Jra (Jra^76-19). (Hou et al., 1997) Ommatidia differentiate additional R7 cells, phenotype suppressed by P{sE-D-jun^{S82A,T92A,T107A}}. (Peverali et al., 1996) Rough eye phenotype is slightly suppressed by Jra^{bZIP.hs.sev.T:Ivir\HA1}. (Bohmann et al., 1994) The sev signalling pathway is activated, even in the absence of the boss inducing signal: flies show positive phototaxis towards UV light. Eyes show multiple R7 cells. Embryos from heterozygous females show reduced numbers of abdominal segments though the head skeleton and filzkorper do develop. As for dominant Egfr mutants, heterozygotes have extra wing vein material. (Brunner et al., 1994) Ommatidia contain many R7 cells. rl^Sem/rl⁺;pnt¹²⁷⁷/pnt^Δ88 double mutant flies possess either one or no R7 cells and occasionally lack R1-R6 cells. (Brunner et al., 1994) Clonal analysis reveals phenotypes in the adult including loss of wing vein, ectopic wing vein, reduced cell size, cell lethality and tergite bristle abnormalities. (Diaz-Benjumea and Hafen, 1994) Rough eyes and extra wing veins. Formation of supernumerary R7 photoreceptor cells. (Rusch and Levine, 1994) rl^Sem is a dominant allele that causes the formation of R7 photoreceptors even in the absence of boss or sev. rl^Sem also causes extra wing vein material and a dominant tor phenotype.
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference rl^Sem has visible \| dominant phenotype, enhanceable by pum⁷/pum[+] (Kim et al., 2012) rl^Sem has visible phenotype, enhanceable by ed[+]/ed^1X5 (Bai et al., 2001)
NOT Enhanced by
Statement Reference rl^Sem has visible phenotype, non-enhanceable by SelD^k11320 (Morey et al., 2001)
Suppressed by
Statement Reference rl^Sem has visible phenotype, suppressible by msk[+]/msk² (Lorenzen et al., 2001) rl^Sem has visible phenotype, suppressible by msk[+]/msk⁵ (Lorenzen et al., 2001)
NOT suppressed by
Statement Reference rl^Sem has visible phenotype, non-suppressible by msk⁴ (Baker et al., 2002) rl^Sem has visible phenotype, non-suppressible by msk⁵ (Baker et al., 2002) rl^Sem has visible phenotype, non-suppressible by SelD^k11320 (Morey et al., 2001)
Enhancer of
Statement Reference rl[+]/rl^Sem is an enhancer of visible phenotype of Mad^Scer\UAS.cNa, Scer\GAL4^vg.int2.1 (Zeng et al., 2007) rl^Sem is an enhancer of visible phenotype of BacA\p35^GMR.PH, Dp^GMR.PD, E2f^GMR.PD (Staehling-Hampton et al., 1999)
Suppressor of
Statement Reference rl[+]/rl^Sem is a suppressor of lethal \| partially phenotype of phl¹ (Brunner et al., 1994) rl[+]/rl^Sem is a suppressor of lethal \| partially phenotype of phl¹² (Brunner et al., 1994) rl[+]/rl^Sem is a suppressor of lethal \| partially phenotype of phl¹⁰⁷ (Brunner et al., 1994) rl[+]/rl^Sem is a suppressor of visible \| somatic clone phenotype of Ras85D^D38E, Ras85D^x7b (Halfar et al., 2001) rl^Sem is a suppressor of lethal phenotype of W^hs.PG (Bergmann et al., 1998) rl^Sem is a suppressor of visible phenotype of lace²/lace^k05305 (Adachi-Yamada et al., 1999) rl^Sem is a suppressor of visible phenotype of PTP-ER^hs.sev (Karim and Rubin, 1999)
NOT Suppressor of
Statement Reference rl[+]/rl^Sem is a non-suppressor of visible \| recessive \| somatic clone phenotype of Ras85D^x7b (Halfar et al., 2001)
Phenotype Manifest In
Enhanced by
Statement Reference rl^Sem has midline glial cell phenotype, enhanceable by W^unspecified/W^unspecified (Bergmann et al., 2002) rl^Sem has phenotype, enhanceable by bs⁰³²⁶⁷ (Roch et al., 1998) rl^Sem has wing vein \| ectopic phenotype, enhanceable by ash2[+]/ash2^I1 (Angulo et al., 2004) rl^Sem has wing vein \| ectopic phenotype, enhanceable by Egfr^unspecified (Brunner et al., 1994) rl^Sem has wing vein \| ectopic phenotype, enhanceable by Gug³⁵/Gug[+] (Charroux et al., 2006) rl^Sem has wing vein \| ectopic phenotype, enhanceable by Gug^1207D6/Gug[+] (Charroux et al., 2006) rl^Sem has wing vein \| ectopic phenotype, enhanceable by Gug⁰³⁹²⁸/Gug[+] (Charroux et al., 2006) rl^Sem has wing vein \| ectopic phenotype, enhanceable by Gug¹⁴⁹⁶⁷/Gug[+] (Charroux et al., 2006) rl^Sem has wing vein \| ectopic phenotype, enhanceable by pum⁷ (Kim et al., 2012) rl^Sem has wing vein \| supernumerary phenotype, enhanceable by ed[+]/ed^1X5 (Bai et al., 2001) rl^Sem has wing vein phenotype, enhanceable by ed^1X5 (Hsu et al., 1998)
NOT Enhanced by
Statement Reference rl^Sem has eye phenotype, non-enhanceable by SelD^k11320 (Morey et al., 2001) rl^Sem has phenotype, non-enhanceable by lilli^s35 (Tang et al., 2001) rl^Sem has phenotype, non-enhanceable by lilli^XS407 (Tang et al., 2001) rl^Sem has phenotype, non-enhanceable by lilli^XS575 (Tang et al., 2001) rl^Sem has phenotype, non-enhanceable by Shc^111-40 (Luschnig et al., 2000) rl^Sem has phenotype, non-enhanceable by Shc^BG (Luschnig et al., 2000) rl^Sem has photoreceptor cell phenotype, non-enhanceable by SelD^k11320 (Morey et al., 2001)
Suppressed by
Statement Reference rl^Sem has eye phenotype, suppressible by TfIIA-S^E73 (Zeidler et al., 1996) rl^Sem has eye photoreceptor cell \| ectopic phenotype, suppressible by Jra¹ (Kockel et al., 1997) rl^Sem has eye photoreceptor cell \| ectopic phenotype, suppressible by Jra^IA109 (Kockel et al., 1997) rl^Sem has photoreceptor cell R7 \| supernumerary phenotype, suppressible by Mkp3^hs.sev (Rintelen et al., 2003) rl^Sem has wing vein \| ectopic phenotype, suppressible by Gug^{Ubi-p63E.T:Avic\GFP} (Charroux et al., 2006) rl^Sem has wing vein \| ectopic phenotype, suppressible by kay² (Ciapponi et al., 2001) rl^Sem has wing vein \| ectopic phenotype, suppressible by msk[+]/msk² (Lorenzen et al., 2001) rl^Sem has wing vein \| ectopic phenotype, suppressible by msk[+]/msk⁵ (Lorenzen et al., 2001)
NOT suppressed by
Statement Reference rl^Sem has denticle belt \| maternal effect phenotype, non-suppressible by Stat92E⁰⁶³⁴⁶/Stat92E⁰⁶³⁴⁶ (Li et al., 2002) rl^Sem has eye phenotype, non-suppressible by SelD^k11320 (Morey et al., 2001) rl^Sem has phenotype, non-suppressible by lilli^s35 (Tang et al., 2001) rl^Sem has phenotype, non-suppressible by lilli^XS407 (Tang et al., 2001) rl^Sem has phenotype, non-suppressible by lilli^XS575 (Tang et al., 2001) rl^Sem has phenotype, non-suppressible by rin¹ (Pazman et al., 2000) rl^Sem has phenotype, non-suppressible by rin² (Pazman et al., 2000) rl^Sem has phenotype, non-suppressible by Shc^111-40 (Luschnig et al., 2000) rl^Sem has phenotype, non-suppressible by Shc^BG (Luschnig et al., 2000) rl^Sem has photoreceptor cell phenotype, non-suppressible by SelD^k11320 (Morey et al., 2001) rl^Sem has wing vein \| ectopic phenotype, non-suppressible by kay^hs.PZ/kay² (Ciapponi et al., 2001) rl^Sem has wing vein \| ectopic phenotype, non-suppressible by msk⁴ (Baker et al., 2002) rl^Sem has wing vein \| ectopic phenotype, non-suppressible by msk⁵ (Baker et al., 2002) rl^Sem has wing vein \| ectopic phenotype, non-suppressible by SelD^k11320 (Morey et al., 2001) rl^Sem has wing vein \| supernumerary phenotype, non-suppressible by Scer\GAL4^en-GAL4-33/Mkp3^Scer\UAS.cRa (Rintelen et al., 2003)
Enhancer of
Statement Reference rl[+]/rl^Sem is an enhancer of eye phenotype of Egfr^E1 (Brunner et al., 1994) rl[+]/rl^Sem is an enhancer of eye phenotype of Egfr^E3 (Brunner et al., 1994) rl[+]/rl^Sem is an enhancer of wing phenotype of Mad^Scer\UAS.cNa, Scer\GAL4^vg.int2.1 (Zeng et al., 2007) rl[+]/rl^Sem is an enhancer of wing vein \| ectopic phenotype of Hsap\ATN1^{N917.65Q.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Charroux et al., 2006) rl[+]/rl^Sem is an enhancer of wing vein \| ectopic phenotype of Mad^Scer\UAS.cNa, Scer\GAL4^vg.int2.1 (Zeng et al., 2007) rl^Sem/rl^Sem is an enhancer of midline glial cell phenotype of W^rvX1 (Bergmann et al., 2002, Bergmann et al., 2002) rl^Sem is an enhancer of phenotype of svp^1.sev (Begemann et al., 1995) rl^Sem is an enhancer of phenotype of svp^2.sev (Begemann et al., 1995) rl^Sem is an enhancer of wing vein \| ectopic phenotype of Egfr^E1 (Brunner et al., 1994) rl^Sem is an enhancer of wing vein \| ectopic phenotype of Egfr^E3 (Brunner et al., 1994)
NOT Enhancer of
Statement Reference rl^Sem is a non-enhancer of phenotype of Doa⁷/Doa^HD (Yun et al., 2000) rl^Sem is a non-enhancer of phenotype of Doa^HD/Doa^Dem (Yun et al., 2000) rl^Sem is a non-enhancer of wing disc phenotype of ft^k07918 (Garoia et al., 2000)
Suppressor of
Statement Reference rl[+]/rl^Sem is a suppressor of adult head \| somatic clone phenotype of Ras85D^D38E, Ras85D^x7b (Halfar et al., 2001) rl[+]/rl^Sem is a suppressor of eye \| somatic clone phenotype of Ras85D^D38E, Ras85D^x7b (Halfar et al., 2001) rl^Sem is a suppressor of eye phenotype of PTP-ER^hs.sev (Karim and Rubin, 1999) rl^Sem is a suppressor of eye phenotype of rpr^GMR.PW (Kurada and White, 1998) rl^Sem is a suppressor of eye phenotype of W^Ala3.GMR (Bergmann et al., 1998) rl^Sem is a suppressor of eye phenotype of W^Ala5.GMR (Bergmann et al., 1998) rl^Sem is a suppressor of eye phenotype of W^GMR.PG/W^GMR.PG (Kurada and White, 1998, Bergmann et al., 1998) rl^Sem is a suppressor of microchaeta phenotype of lace²/lace^k05305 (Adachi-Yamada et al., 1999) rl^Sem is a suppressor of midline glial cell phenotype of comm^Δe39 (Bergmann et al., 2002) rl^Sem is a suppressor of ommatidium phenotype of PTP-ER^hs.sev (Karim and Rubin, 1999) rl^Sem is a suppressor of ommatidium phenotype of W^GMR.PG/W^GMR.PG (Bergmann et al., 1998) rl^Sem is a suppressor of phenotype of csw^lf (Firth et al., 2000) rl^Sem is a suppressor of phenotype of vn^ddd-13 (Schnepp et al., 1996) rl^Sem is a suppressor of phenotype of vn^L6 (Schnepp et al., 1996) rl^Sem is a suppressor of photoreceptor cell phenotype of PTP-ER^hs.sev (Karim and Rubin, 1999) rl^Sem is a suppressor of photoreceptor cell R7 phenotype of PTP-ER^hs.sev (Karim and Rubin, 1999) rl^Sem is a suppressor of wing phenotype of lace²/lace^k05305 (Adachi-Yamada et al., 1999)
NOT Suppressor of
Statement Reference rl[+]/rl^Sem is a non-suppressor of bouton \| supernumerary phenotype of Fas2^e76 (Koh et al., 2002) rl[+]/rl^Sem is a non-suppressor of eye \| somatic clone phenotype of Ras85D^x7b (Halfar et al., 2001) rl^Sem is a non-suppressor of phenotype of Doa⁷/Doa^HD (Yun et al., 2000) rl^Sem is a non-suppressor of phenotype of Doa^HD/Doa^Dem (Yun et al., 2000) rl^Sem is a non-suppressor of wing disc phenotype of ft^k07918 (Garoia et al., 2000)
Other
Statement Reference da², rl[+]/rl^Sem has follicle cell phenotype (Smith et al., 2002) da², rl^Sem has follicle cell phenotype (Smith et al., 2002) phl¹, rl[+]/rl^Sem has photoreceptor cell phenotype (Brunner et al., 1994) phl¹², rl[+]/rl^Sem has photoreceptor cell phenotype (Brunner et al., 1994)
Additional Comments
Genetic Interactions
Statement Reference Heterozygous pum[7] greatly enhances the dominant extra wing vein phenotype of rl[Sem]. (Kim et al., 2012) S6kII[ign-Δ58-1]/Y ; rl[Sem]/+ double mutant larvae do not have a higher number of boutons at the neuromuscular junction than either single mutant. (Fischer et al., 2009) rl[Sem]/+ enhances the mutant wing phenotype caused by expression of Mad[Scer\UAS.cNa] under the control of Scer\GAL4[vg.int2.1]. (Zeng et al., 2007) The ectopic wing vein material phenotype of flies expressing rl^Sem is enhanced in Gug⁰³⁹²⁸, Gug³⁵, Gug^1207D6 and Gug¹⁴⁹⁶⁷ heterozygotes. Expression of Gug^{Ubi-p63E.T:Avic\GFP} suppresses the extra wing vein material formation seen in rl^Sem mutants. (Charroux et al., 2006) Formation of ectopic vein tissue in rl[Sem]/+ animals is enhanced by ash2[I1]/+. (Angulo et al., 2004) The rl^Sem extra wing vein phenotype is unaffected by the expression of Mkp3^Scer\UAS.cRa under the control of Scer\GAL4^en-GAL4-33. The formation of additional R7 cells seen in rl^Sem flies is almost completely suppressed by the expression of Mkp3^hs.sev. (Rintelen et al., 2003) The increase in midline glial cells seen in rl^Sem mutant embryos is slightly enhanced by W^unspecified/W^unspecified (from 6 (n=231) to 6.6 (n=91)). The reduction in midline glial cell numbers seen in comm^Δe39 mutant embryos is suppressed in double mutants with rl^Sem. These rescued midline glial cells are scattered throughout the midline, which lacks axons in these animals. (Bergmann et al., 2002) Double mutants of Fas2^e76 rl^Sem do not exhibit a bouton number significantly different from that found in the Fas2^e76 mutant alone. (Koh et al., 2002) rl^Sem/+ alone is not sufficient to rescue the reduced eye and head phenotypes of flies that are homozygous for Ras85D^x7b in the eye disc. However, the addition of Ras85D^D38E in combination with rl^Sem results in a substantial rescue of the Ras85D^x7b eye and head size phenotypes; differentiated photoreceptor cells are seen and a substantial fraction of the ommatidia contain the full complement of photoreceptors. (Halfar et al., 2001) The addition of one copy of SelD^k11320 to rl^Sem/+ fliers has no effect on the eye phenotype. (Morey et al., 2001) Suppresses the wing margin incision and loss of microchaetae phenotypes of lace^k05305/lace² flies. (Adachi-Yamada et al., 1999) rl^Sem completely suppresses the PTP-ER^hs.sev phenotype, to the point of producing ectopic R7 cells as seen in mutants in rl^Sem alone. (Karim and Rubin, 1999) Enhances the phenotype of E2f^GMR.PD Dp^GMR.PD BacA\p35^GMR.PH flies. (Staehling-Hampton et al., 1999) Suppression of W^Ala3.GMR and W^Ala5.GMR is very mild and noticeably less evident than that of W^GMR.PG. (Bergmann et al., 1998) At 25^oC rl^Sem dominantly enhances most of the hyperplastic growth seen in Ras85D^V12.Scer\UAS Scer\GAL4^dpp.blk1 wing discs resulting in a much larger disc with severe disruptions of morphology. Ras85D^{V12.G37.Scer\UAS} Scer\GAL4^dpp.blk1 and rl^Sem act synergistically to produce a small amount of hyperplastic growth in third instar wing discs. Mutants die as pharate adults at 25^oC and have deletions of tarsal segments and extra wing vein material along L3. No ectopic proliferation is seen with Ras85D^{V12.C40.Scer\UAS}. The adults often have wing blisters and extra vein material along L3. This phenotype is not suppressed by phl^XS-2541. (Karim and Rubin, 1998) Suppresses the eye reduction phenotype caused by rpr^GMR.PW. Suppresses the eye reduction phenotype caused by W^GMR.PG. (Kurada and White, 1998) Appearance of ectopic photoreceptor cells in the adult eye is suppressed by loss of a functional copy of Jra (Jra¹ or Jra^IA109). (Kockel et al., 1997) Suppresses the viability of vn^ddd-13 and proliferation defects in vn^L6. (Schnepp et al., 1996) TfIIA-S^E73 suppresses the rough eye phenotype of sev^{S11.T:Hsap\MYC}, phl::tor^12D.hs.sev, Ras85D^V12.sev, rl^Sem and svp^2.sev. (Zeidler et al., 1996) Enhancer of the dosage-dependent (two or more copies of P{sev-svp1} or P{sev-svp2}) transformation of cone cells into R7 photoreceptors and at a lower frequency R7 cells into outer photoreceptors. (Begemann et al., 1995) Eyes show multiple R7 cells, even in a sev^- mutant background. rl^Sem suppresses the reduced viability associated with phl¹², phl¹ and phl¹⁰⁷, and the eye phenotype of phl¹. Homozygous tll¹ embryos from rl^Sem/+ mothers have a tll mutant phenotype. The extra wing vein phenotype of heterozygotes is enhanced in transheterozygotes with dominant Egfr alleles. Flies heterozygous for Egfr^E3 or Egfr^E1 and rl^Sem have smaller eyes than Egfr^E3 or Egfr^E1 heterozygotes alone. (Brunner et al., 1994)
Xenogenetic Interactions
Statement Reference The ectopic wing vein phenotype seen when Hsap\ATN1^{N917.65Q.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PF is enhanced in rl^Sem heterozygotes. (Charroux et al., 2006)
Complementation & Rescue Data
Comments
Stocks ( 1 )
Kyoto	108365 rl^Sem/CyO/Dp(?;2)bw^D, S¹ wg^Sp-1 Ms(2)M¹ bw^D
Notes on Origin
Discoverer

Comments
	The mutation in rl^Su23 is identical to that found in rl^Sem. (Lim et al., 1999) Phenotypes of rl mutants fall into an allelic series: Df(2R)rl10a/rl¹ >= rl⁹/rl¹ > rl^la8/rl¹ > rl¹⁰/rl¹ > rl¹/rl¹. (Diaz-Benjumea and Hafen, 1994) Hyperactivated form of the rl kinase. (Rusch and Levine, 1994)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	DERK^sem (Mahalingam et al., 2008) MAPK^Sem (Karim and Rubin, 1998) rl/MAPK^Sem (Begemann et al., 1995) rl^<up>Sem</up> (Kim et al., 2012) rl^sem (Marenda et al., 2006, Boulton et al., 2000, Takatsu et al., 2000) rl^SEM (Koh et al., 2002, Li et al., 2002, Bai et al., 2001, Lorenzen et al., 2001, Firth et al., 2000, Pazman et al., 2000, Bai et al., 1999) rl^Sem (Charroux et al., 2006, Fischer et al., 2009, Zeng et al., 2007) rolled^Sem (Karim and Rubin, 1998) Sem (Roch et al., 1998, Karim and Rubin, 1998)
Name Synonym	rolled^SEM (Jones et al., 2006) Sevenmaker (Brunner et al., 1994)
Secondary FlyBase IDs

References ( 61 )

Generate a list of	All references relating to this allele ( 61 )

List References by type	Research paper ( 51 ) Review ( 5 ) Abstract ( 5 )
Recent research papers ( 1 )
	Kim et al., 2012, PLoS ONE 7(4): e34016 Negative Regulation of EGFR/MAPK Pathway by Pumilio in Drosophila melanogaster. [FBrf0218126] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...

Allele Dmel\rlSem

Allele Dmel\rl^Sem