FlyBase Allele Report: Dmel\rl[Sem]

General Information

Symbol

Dmel\rl^Sem

Species

D. melanogaster

Name

Sevenmaker

FlyBase ID

FBal0014598

Feature type

allele

Associated gene

Dmel\rl

Associated Insertion(s)

Carried in Construct

Also Known As

Sem, rolled^Sem

Genomic Maps

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Help me choose

Allele class

hypomorphic allele - genetic evidence

gain of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

gain of function allele

(Bergmann et al., 1998, Karim and Rubin, 1998, Kockel et al., 1997, Brunner et al., 1994, Brunner et al., 1994)

hypomorphic allele - genetic evidence

(Kurada and White, 1998)

Mutagen

ethyl methanesulfonate

(Brunner et al., 1994)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

point mutation

2R:1,113,720..1,113,720 [+]

Nucleotide change:

G1113720A

Amino acid change:

Reported amino acid change:

D334N

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Brunner et al., 1994)

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

Amino acid replacement: D334N. Amino acid 334 is located at the C-terminal end of kinase domain XI and is conserved in the different members of the MAP kinase family.

(Brunner et al., 1994)

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

bouton | supernumerary

(Koh et al., 2002)

denticle belt | maternal effect

(Li et al., 2002)

embryonic/larval neuromuscular junction

(Beck et al., 2015)

embryonic abdominal segment 1 | maternal effect

(Brunner et al., 1994)

embryonic abdominal segment 2 | maternal effect

(Brunner et al., 1994)

embryonic abdominal segment 3 | maternal effect

(Brunner et al., 1994)

embryonic abdominal segment 4 | maternal effect

(Brunner et al., 1994)

embryonic abdominal segment 5 | maternal effect

(Brunner et al., 1994)

embryonic abdominal segment 6 | maternal effect

(Brunner et al., 1994)

embryonic abdominal segment 7 | maternal effect

(Brunner et al., 1994)

embryonic abdominal segment 8 | maternal effect

(Brunner et al., 1994)

embryonic abdominal segment 9 | maternal effect

(Brunner et al., 1994)

embryonic abdominal segment 10 | maternal effect

(Brunner et al., 1994)

embryonic abdominal segment 11 | maternal effect

(Brunner et al., 1994)

eye

(Morey et al., 2001, Luschnig et al., 2000, Karim and Rubin, 1998, Kurada and White, 1998, Zeidler et al., 1996)

eye | maternal effect

(Brunner et al., 1994)

eye photoreceptor cell | ectopic

(Kockel et al., 1997)

macrochaeta

(Diaz-Benjumea and Hafen, 1994)

midline glial cell

(Bergmann et al., 2002)

NMJ bouton | larval stage

(Fischer et al., 2009)

ommatidium

(Kumar et al., 2003, Luschnig et al., 2000)

ommatidium, with rl^{MG.GMR.Tag:HSV-1-gD}

(Kumar et al., 2003)

ommatidium, with rl^{NMG.GMR.Tag:NLS(SV40-largeT),Tag:HSV-1-gD}

(Kumar et al., 2003)

photoreceptor cell

(Morey et al., 2001, Hou et al., 1997, Peverali et al., 1996)

photoreceptor cell R7

(Brunner et al., 1994, Rusch and Levine, 1994)

photoreceptor cell R7 | ectopic | maternal effect

(Brunner et al., 1994)

photoreceptor cell R7 | supernumerary

(Rintelen et al., 2003)

pigment cell

(Kurada and White, 1998)

presynaptic active zone

(Beck et al., 2015)

wing

(Roch et al., 1998)

wing vein

(Hall and Verheyen, 2015, Tchankouo-Nguetcheu et al., 2014, Karim and Rubin, 1998, Diaz-Benjumea and Hafen, 1994, Rusch and Levine, 1994)

wing vein | ectopic

(Tchankouo-Nguetcheu et al., 2014, Kim et al., 2012, Zeng et al., 2007, Charroux et al., 2006, Marenda et al., 2006, Angulo et al., 2004, Baker et al., 2002, Lorenzen et al., 2001, Morey et al., 2001, Karim and Rubin, 1998, Diaz-Benjumea and Hafen, 1994)

wing vein | ectopic | maternal effect

(Brunner et al., 1994)

wing vein | supernumerary

(Rintelen et al., 2003, Bai et al., 2001)

Detailed Description

Statement

Reference

rl^Sem mutants exhibit significant reductions in NMJ size and numbers of pre-synaptic active zones and post-synaptic GluRIID fields. The areas of the active zones and GluRIID fields are unchanged compared with controls.

(Beck et al., 2015)

rl^Sem/+ wings contain excess vein material.

(Hall and Verheyen, 2015)

Heterozygotes have thickened and ectopic wing venation, particularly in the anterior cross vein.

(Tchankouo-Nguetcheu et al., 2014)

Heterozygous rl^Sem produces extra wing vein material.

(Kim et al., 2012)

Absolute bouton number and bouton number per muscle area is significantly increased in heterozygous larvae compared to controls at the neuromuscular junction in segment A3 in muscle 6/7.

(Fischer et al., 2009)

Heterozygotes have ectopic veins in the wing.

(Zeng et al., 2007)

rl^Sem/+ flies have ectopic vein material in the wing.

(Charroux et al., 2006)

rl^Sem mutants exhibit extra wing veins.

(Marenda et al., 2006)

The wings of rl^Sem/+ animals form scattered fragments of ecoptic vein tissue in intervein regions.

(Angulo et al., 2004)

Heterozygotes have a rough eye phenotype, which is enhanced if these flies also express rl^{GMR.T:Scer\GAL4,T:Hsim\VP16,T:Hsim\gD} or rl^{GMR.T:SV40\nls2,T:Scer\GAL4,T:Hsim\VP16,T:Hsim\gD}.

(Kumar et al., 2003)

rl^Sem flies have an extra wing vein phenotype. Additional R7 cells are formed in the eye.

(Rintelen et al., 2003)

At stage 17 rl^Sem mutant embryos have an average of 6 midline glial cells per segment (n=231), compared to 2.8 per segment in wild-type.

(Bergmann et al., 2002)

rl^Sem/+ mutants exhibit a significant increase in the number of synaptic boutons compared to wild-type.

(Koh et al., 2002)

10.7% of embryos derived from heterozygous females have less than 4 denticle belts.

(Li et al., 2002)

Extra wing veins develop.

(Bai et al., 2001)

Heterozygous rl^Sem animals display a mild rough eye phenotype.

(Morey et al., 2001)

Flies carrying rl^Sem have a rough eye phenotype.

(Luschnig et al., 2000)

Heterozygous females show a weak dominant sterility; 10.2% of the eggs laid by these females fail to hatch and 20.0% of these nonviable embryos have defects similar to those associated with gain-of-function alleles of tor.

(Lim et al., 1999)

Mutants display no apparent proliferation defect. Adult have moderately rough eyes and extra wing vein material.

(Karim and Rubin, 1998)

Shows supernumerary pigment cells in the developing eye, due to failure of apoptosis.

(Kurada and White, 1998)

rl^Sem/+ shows ectopic wing vein tissue.

(Roch et al., 1998)

Adults exhibit a rough eye phenotype that cannot be suppressed by heterozygosity for Jra (Jra^76-19).

(Hou et al., 1997)

Ommatidia differentiate additional R7 cells, phenotype suppressed by P{sE-D-jun^{S82A,T92A,T107A}}.

(Peverali et al., 1996)

Rough eye phenotype is slightly suppressed by Jra^{bZIP.hs.sev.T:Ivir\HA1}.

(Bohmann et al., 1994)

The sev signalling pathway is activated, even in the absence of the boss inducing signal: flies show positive phototaxis towards UV light. Eyes show multiple R7 cells. Embryos from heterozygous females show reduced numbers of abdominal segments though the head skeleton and filzkorper do develop. As for dominant Egfr mutants, heterozygotes have extra wing vein material.

(Brunner et al., 1994)

Ommatidia contain many R7 cells. rl^Sem/rl⁺;pnt¹²⁷⁷/pnt^Δ88 double mutant flies possess either one or no R7 cells and occasionally lack R1-R6 cells.

(Brunner et al., 1994)

Clonal analysis reveals phenotypes in the adult including loss of wing vein, ectopic wing vein, reduced cell size, cell lethality and tergite bristle abnormalities.

(Diaz-Benjumea and Hafen, 1994)

Rough eyes and extra wing veins. Formation of supernumerary R7 photoreceptor cells.

(Rusch and Levine, 1994)

rl^Sem is a dominant allele that causes the formation of R7 photoreceptors even in the absence of boss or sev. rl^Sem also causes extra wing vein material and a dominant tor phenotype.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

rl^Sem has visible | dominant phenotype, enhanceable by pum⁷/pum[+]

(Kim et al., 2012)

rl^Sem has visible phenotype, enhanceable by ed[+]/ed^1X5

(Bai et al., 2001)

NOT Enhanced by

Statement

Reference

rl^Sem has visible phenotype, non-enhanceable by Sps1^k11320

(Morey et al., 2001)

Suppressed by

Statement

Reference

rl^Sem has visible phenotype, suppressible by msk[+]/msk⁵

(Lorenzen et al., 2001)

rl^Sem has visible phenotype, suppressible by msk[+]/msk²

(Lorenzen et al., 2001)

NOT suppressed by

Statement

Reference

rl^Sem has visible phenotype, non-suppressible by msk⁵

(Baker et al., 2002)

rl^Sem has visible phenotype, non-suppressible by msk⁴

(Baker et al., 2002)

rl^Sem has visible phenotype, non-suppressible by Sps1^k11320

(Morey et al., 2001)

Enhancer of

Statement

Reference

rl[+]/rl^Sem is an enhancer of visible phenotype of Mad^UAS.cNa, Scer\GAL4^vg.int2.1

(Zeng et al., 2007)

rl^Sem is an enhancer of visible phenotype of BacA\p35^GMR.PH, Dp^GMR.PD, E2f1^GMR.PD

(Staehling-Hampton et al., 1999)

rl^Sem is an enhancer of hyperplasia | larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^dpp.blk1

(Karim and Rubin, 1998)

Suppressor of

Statement

Reference

rl[+]/rl^Sem is a suppressor of visible | somatic clone phenotype of Ras85D^D38E, Ras85D^x7b

(Halfar et al., 2001)

rl^Sem is a suppressor of visible phenotype of lace²/lace^k05305

(Adachi-Yamada et al., 1999)

rl^Sem is a suppressor of visible phenotype of PTP-ER^hs.sev

(Karim and Rubin, 1999)

rl^Sem is a suppressor of lethal phenotype of hid^hs.PG

(Bergmann et al., 1998)

rl^Sem/rl⁺ is a suppressor of partially lethal phenotype of Raf¹⁰⁷

(Brunner et al., 1994)

rl^Sem/rl⁺ is a suppressor of partially lethal phenotype of Raf¹²

(Brunner et al., 1994)

rl^Sem/rl⁺ is a suppressor of partially lethal phenotype of Raf¹

(Brunner et al., 1994)

NOT Suppressor of

Statement

Reference

rl^Sem/rl⁺ is a non-suppressor of lethal phenotype of slpr^BS06

(Baril et al., 2009)

rl[+]/rl^Sem is a non-suppressor of visible | recessive | somatic clone phenotype of Ras85D^x7b

(Halfar et al., 2001)

Other

Statement

Reference

Dsor1^GD9123, Scer\GAL4^en.PU, rl^Sem/rl⁺ has visible | adult stage phenotype

(Hall and Verheyen, 2015)

Ptp61F^{dsRNA.UAS.WIZ}, Scer\GAL4^GMR.PU, rl^Sem has size defective phenotype

(Tchankouo-Nguetcheu et al., 2014)

Ptp61F[+]/Ptp61F^4-10, rl^Sem has size defective phenotype

(Tchankouo-Nguetcheu et al., 2014)

Ptp61F^GD3571, Scer\GAL4^GMR.PU, rl^Sem has size defective phenotype

(Tchankouo-Nguetcheu et al., 2014)

Phenotype Manifest In

Enhanced by

Statement

Reference

rl^Sem has wing vein phenotype, enhanceable by Ptp61F^{dsRNA.UAS.WIZ}/Scer\GAL4^GMR.PU

(Tchankouo-Nguetcheu et al., 2014)

rl^Sem has wing vein | ectopic phenotype, enhanceable by Ptp61F^{dsRNA.UAS.WIZ}/Scer\GAL4^GMR.PU

(Tchankouo-Nguetcheu et al., 2014)

rl^Sem has wing vein phenotype, enhanceable by Ptp61F[+]/Ptp61F^4-10

(Tchankouo-Nguetcheu et al., 2014)

rl^Sem has wing vein | ectopic phenotype, enhanceable by Ptp61F[+]/Ptp61F^4-10

(Tchankouo-Nguetcheu et al., 2014)

rl^Sem has wing vein phenotype, enhanceable by Ptp61F^GD3571/Scer\GAL4^GMR.PU

(Tchankouo-Nguetcheu et al., 2014)

rl^Sem has wing vein | ectopic phenotype, enhanceable by Ptp61F^GD3571/Scer\GAL4^GMR.PU

(Tchankouo-Nguetcheu et al., 2014)

rl^Sem has wing vein | ectopic phenotype, enhanceable by pum⁷

(Kim et al., 2012)

rl^Sem has wing vein | ectopic phenotype, enhanceable by Gug³⁵/Gug[+]

(Charroux et al., 2006)

rl^Sem has wing vein | ectopic phenotype, enhanceable by Gug⁰³⁹²⁸/Gug[+]

(Charroux et al., 2006)

rl^Sem has wing vein | ectopic phenotype, enhanceable by Gug^1207D6/Gug[+]

(Charroux et al., 2006)

rl^Sem has wing vein | ectopic phenotype, enhanceable by Gug¹⁴⁹⁶⁷/Gug[+]

(Charroux et al., 2006)

rl^Sem has wing vein | ectopic phenotype, enhanceable by ash2[+]/ash2^I1

(Angulo et al., 2004)

rl^Sem has midline glial cell phenotype, enhanceable by hid^unspecified/hid^unspecified

(Bergmann et al., 2002)

rl^Sem has wing vein | supernumerary phenotype, enhanceable by ed[+]/ed^1X5

(Bai et al., 2001)

rl^Sem has wing vein phenotype, enhanceable by ed^1X5

(Hsu et al., 1998)

rl^Sem has phenotype, enhanceable by bs⁰³²⁶⁷

(Roch et al., 1998)

rl^Sem has wing vein | ectopic phenotype, enhanceable by Egfr^unspecified

(Brunner et al., 1994)

NOT Enhanced by

Statement

Reference

rl^Sem has eye phenotype, non-enhanceable by Sps1^k11320

(Morey et al., 2001)

rl^Sem has photoreceptor cell phenotype, non-enhanceable by Sps1^k11320

(Morey et al., 2001)

rl^Sem has phenotype, non-enhanceable by lilli^XS407/lilli^XS407

(Tang et al., 2001)

rl^Sem has phenotype, non-enhanceable by lilli^XS575

(Tang et al., 2001)

rl^Sem has phenotype, non-enhanceable by lilli^s35

(Tang et al., 2001)

rl^Sem has phenotype, non-enhanceable by Shc^111-40

(Luschnig et al., 2000)

rl^Sem has phenotype, non-enhanceable by Shc^BG

(Luschnig et al., 2000)

Suppressed by

Statement

Reference

rl^Sem has wing vein phenotype, suppressible | partially by Ptp61F^UAS.cBa/Scer\GAL4^GMR.PU

(Tchankouo-Nguetcheu et al., 2014)

rl^Sem has wing vein | ectopic phenotype, suppressible | partially by Ptp61F^UAS.cBa/Scer\GAL4^GMR.PU

(Tchankouo-Nguetcheu et al., 2014)

rl^Sem has wing vein | ectopic phenotype, suppressible by Gug^Ubi-p63E.GFP

(Charroux et al., 2006)

rl^Sem has photoreceptor cell R7 | supernumerary phenotype, suppressible by Mkp3^hs.sev

(Rintelen et al., 2003)

rl^Sem has wing vein | ectopic phenotype, suppressible by kay²

(Ciapponi et al., 2001)

rl^Sem has wing vein | ectopic phenotype, suppressible by msk[+]/msk⁵

(Lorenzen et al., 2001)

rl^Sem has wing vein | ectopic phenotype, suppressible by msk[+]/msk²

(Lorenzen et al., 2001)

rl^Sem has eye photoreceptor cell | ectopic phenotype, suppressible by Jra¹

(Kockel et al., 1997)

rl^Sem has eye photoreceptor cell | ectopic phenotype, suppressible by Jra^IA109

(Kockel et al., 1997)

rl^Sem has eye phenotype, suppressible by TfIIA-S^E73

(Zeidler et al., 1996)

NOT suppressed by

Statement

Reference

rl^Sem has wing vein | supernumerary phenotype, non-suppressible by Scer\GAL4^en-GAL4-33/Mkp3^UAS.cRa

(Rintelen et al., 2003)

rl^Sem has wing vein | ectopic phenotype, non-suppressible by msk⁵

(Baker et al., 2002)

rl^Sem has wing vein | ectopic phenotype, non-suppressible by msk⁴

(Baker et al., 2002)

rl^Sem has denticle belt | maternal effect phenotype, non-suppressible by Stat92E⁰⁶³⁴⁶/Stat92E⁰⁶³⁴⁶

(Li et al., 2002)

rl^Sem has wing vein | ectopic phenotype, non-suppressible by kay^hs.PZ/kay²

(Ciapponi et al., 2001)

rl^Sem has photoreceptor cell phenotype, non-suppressible by Sps1^k11320

(Morey et al., 2001)

rl^Sem has wing vein | ectopic phenotype, non-suppressible by Sps1^k11320

(Morey et al., 2001)

rl^Sem has eye phenotype, non-suppressible by Sps1^k11320

(Morey et al., 2001)

rl^Sem has phenotype, non-suppressible by lilli^XS407/lilli^XS407

(Tang et al., 2001)

rl^Sem has phenotype, non-suppressible by lilli^XS575

(Tang et al., 2001)

rl^Sem has phenotype, non-suppressible by lilli^s35

(Tang et al., 2001)

rl^Sem has phenotype, non-suppressible by Shc^111-40

(Luschnig et al., 2000)

rl^Sem has phenotype, non-suppressible by Shc^BG

(Luschnig et al., 2000)

rl^Sem has phenotype, non-suppressible by rin¹

(Pazman et al., 2000)

rl^Sem has phenotype, non-suppressible by rin²

(Pazman et al., 2000)

Enhancer of

Statement

Reference

rl[+]/rl^Sem is an enhancer of wing phenotype of Mad^UAS.cNa, Scer\GAL4^vg.int2.1

(Zeng et al., 2007)

rl[+]/rl^Sem is an enhancer of wing vein | ectopic phenotype of Mad^UAS.cNa, Scer\GAL4^vg.int2.1

(Zeng et al., 2007)

rl[+]/rl^Sem is an enhancer of wing vein | ectopic phenotype of Hsap\ATN1^N917.65Q.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Charroux et al., 2006)

rl^Sem/rl^Sem is an enhancer of midline glial cell phenotype of hid^rvX1

(Bergmann et al., 2002)

rl^Sem is an enhancer of wing disc | larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^dpp.blk1

(Karim and Rubin, 1998)

rl^Sem is an enhancer of phenotype of svp^1.sev

(Begemann et al., 1995)

rl^Sem is an enhancer of phenotype of svp^2.sev

(Begemann et al., 1995)

rl^Sem is an enhancer of wing vein | ectopic phenotype of Egfr^E3

(Brunner et al., 1994)

rl[+]/rl^Sem is an enhancer of eye phenotype of Egfr^E3

(Brunner et al., 1994)

rl^Sem is an enhancer of wing vein | ectopic phenotype of Egfr^E1

(Brunner et al., 1994)

rl[+]/rl^Sem is an enhancer of eye phenotype of Egfr^E1

(Brunner et al., 1994)

NOT Enhancer of

Statement

Reference

rl^Sem is a non-enhancer of wing disc phenotype of ft^k07918

(Garoia et al., 2000)

rl^Sem is a non-enhancer of phenotype of Doa⁷/Doa^HD

(Yun et al., 2000)

rl^Sem is a non-enhancer of phenotype of Doa^HD/Doa^Dem

(Yun et al., 2000)

Suppressor of

Statement

Reference

rl^Sem is a suppressor of midline glial cell phenotype of comm^Δe39

(Bergmann et al., 2002)

rl[+]/rl^Sem is a suppressor of adult head | somatic clone phenotype of Ras85D^D38E, Ras85D^x7b

(Halfar et al., 2001)

rl[+]/rl^Sem is a suppressor of eye | somatic clone phenotype of Ras85D^D38E, Ras85D^x7b

(Halfar et al., 2001)

rl^Sem is a suppressor of phenotype of csw^lf

(Firth et al., 2000)

rl^Sem is a suppressor of wing phenotype of lace²/lace^k05305

(Adachi-Yamada et al., 1999)

rl^Sem is a suppressor of microchaeta phenotype of lace²/lace^k05305

(Adachi-Yamada et al., 1999)

rl^Sem is a suppressor of eye phenotype of PTP-ER^hs.sev

(Karim and Rubin, 1999)

rl^Sem is a suppressor of ommatidium phenotype of PTP-ER^hs.sev

(Karim and Rubin, 1999)

rl^Sem is a suppressor of photoreceptor cell R7 phenotype of PTP-ER^hs.sev

(Karim and Rubin, 1999)

rl^Sem is a suppressor of photoreceptor cell phenotype of PTP-ER^hs.sev

(Karim and Rubin, 1999)

rl^Sem is a suppressor of ommatidium phenotype of hid^GMR.PG/W^GMR.PG

(Bergmann et al., 1998)

rl^Sem is a suppressor of eye phenotype of hid^Ala5.GMR

(Bergmann et al., 1998)

rl^Sem is a suppressor of eye phenotype of hid^Ala3.GMR

(Bergmann et al., 1998)

rl^Sem is a suppressor of eye phenotype of hid^GMR.PG/W^GMR.PG

(Bergmann et al., 1998, Kurada and White, 1998)

rl^Sem is a suppressor of eye phenotype of rpr^GMR.PW

(Kurada and White, 1998)

rl^Sem is a suppressor of phenotype of vn^ddd-13

(Schnepp et al., 1996)

rl^Sem is a suppressor of phenotype of vn^L6

(Schnepp et al., 1996)

NOT Suppressor of

Statement

Reference

rl[+]/rl^Sem is a non-suppressor of bouton | supernumerary phenotype of Fas2^e76

(Koh et al., 2002)

rl[+]/rl^Sem is a non-suppressor of eye | somatic clone phenotype of Ras85D^x7b

(Halfar et al., 2001)

rl^Sem is a non-suppressor of wing disc phenotype of ft^k07918

(Garoia et al., 2000)

rl^Sem is a non-suppressor of phenotype of Doa⁷/Doa^HD

(Yun et al., 2000)

rl^Sem is a non-suppressor of phenotype of Doa^HD/Doa^Dem

(Yun et al., 2000)

Other

Statement

Reference

Dsor1^GD9123, Scer\GAL4^en.PU, rl^Sem/rl⁺ has wing phenotype

(Hall and Verheyen, 2015)

Dsor1^GD9123, Scer\GAL4^en.PU, rl^Sem/rl⁺ has wing vein phenotype

(Hall and Verheyen, 2015)

Ptp61F^{dsRNA.UAS.WIZ}, Scer\GAL4^GMR.PU, rl^Sem has eye phenotype

(Tchankouo-Nguetcheu et al., 2014)

Ptp61F[+]/Ptp61F^4-10, rl^Sem has eye phenotype

(Tchankouo-Nguetcheu et al., 2014)

Ptp61F^GD3571, Scer\GAL4^GMR.PU, rl^Sem has eye phenotype

(Tchankouo-Nguetcheu et al., 2014)

da², rl[+]/rl^Sem has follicle cell phenotype

(Smith et al., 2002)

da², rl^Sem has follicle cell phenotype

(Smith et al., 2002)

Raf¹, rl[+]/rl^Sem has photoreceptor cell phenotype

(Brunner et al., 1994)

Raf¹², rl[+]/rl^Sem has photoreceptor cell phenotype

(Brunner et al., 1994)

Additional Comments

Genetic Interactions

Statement

Reference

Expressing Dsor1^GD9123 under the control of Scer\GAL4^en.PU in a rl^Sem/+ background results in notched wings with a mix of ectopic and lost vein tissue. Wings did not show creases, or the "droopy" phenotype.

(Hall and Verheyen, 2015)

rl^Sem in combination with Ptp61F^4-10/+ or Scer\GAL4^GMR.PU-driven Ptp61F^{dsRNA.Scer\UAS.WIZ} or Ptp61F^GD3571 results in larger than normal eyes.

(Tchankouo-Nguetcheu et al., 2014)

Heterozygous pum⁷ greatly enhances the dominant extra wing vein phenotype of rl^Sem.

(Kim et al., 2012)

rl^Sem/+ does not suppress the lethality of slpr^BS06/Y males.

(Baril et al., 2009)

S6kII^ign-Δ58-1/Y ; rl^Sem/+ double mutant larvae do not have a higher number of boutons at the neuromuscular junction than either single mutant.

(Fischer et al., 2009)

rl^Sem/+ enhances the mutant wing phenotype caused by expression of Mad^Scer\UAS.cNa under the control of Scer\GAL4^vg.int2.1.

(Zeng et al., 2007)

The ectopic wing vein material phenotype of flies expressing rl^Sem is enhanced in Gug⁰³⁹²⁸, Gug³⁵, Gug^1207D6 and Gug¹⁴⁹⁶⁷ heterozygotes.

Expression of Gug^{Ubi-p63E.T:Avic\GFP} suppresses the extra wing vein material formation seen in rl^Sem mutants.

(Charroux et al., 2006)

Formation of ectopic vein tissue in rl^Sem/+ animals is enhanced by ash2^I1/+.

(Angulo et al., 2004)

The rl^Sem extra wing vein phenotype is unaffected by the expression of Mkp3^Scer\UAS.cRa under the control of Scer\GAL4^en-GAL4-33. The formation of additional R7 cells seen in rl^Sem flies is almost completely suppressed by the expression of Mkp3^hs.sev.

(Rintelen et al., 2003)

The increase in midline glial cells seen in rl^Sem mutant embryos is slightly enhanced by W^unspecified/W^unspecified (from 6 (n=231) to 6.6 (n=91)). The reduction in midline glial cell numbers seen in comm^Δe39 mutant embryos is suppressed in double mutants with rl^Sem. These rescued midline glial cells are scattered throughout the midline, which lacks axons in these animals.

(Bergmann et al., 2002)

Double mutants of Fas2^e76 rl^Sem do not exhibit a bouton number significantly different from that found in the Fas2^e76 mutant alone.

(Koh et al., 2002)

rl^Sem/+ alone is not sufficient to rescue the reduced eye and head phenotypes of flies that are homozygous for Ras85D^x7b in the eye disc. However, the addition of Ras85D^D38E in combination with rl^Sem results in a substantial rescue of the Ras85D^x7b eye and head size phenotypes; differentiated photoreceptor cells are seen and a substantial fraction of the ommatidia contain the full complement of photoreceptors.

(Halfar et al., 2001)

The addition of one copy of SelD^k11320 to rl^Sem/+ fliers has no effect on the eye phenotype.

(Morey et al., 2001)

Suppresses the wing margin incision and loss of microchaetae phenotypes of lace^k05305/lace² flies.

(Adachi-Yamada et al., 1999)

rl^Sem completely suppresses the PTP-ER^hs.sev phenotype, to the point of producing ectopic R7 cells as seen in mutants in rl^Sem alone.

(Karim and Rubin, 1999)

Enhances the phenotype of E2f^GMR.PD Dp^GMR.PD BacA\p35^GMR.PH flies.

(Staehling-Hampton et al., 1999)

Suppression of W^Ala3.GMR and W^Ala5.GMR is very mild and noticeably less evident than that of W^GMR.PG.

(Bergmann et al., 1998)

At 25[o]C rl^Sem dominantly enhances most of the hyperplastic growth seen in Ras85D^V12.Scer\UAS Scer\GAL4^dpp.blk1 wing discs resulting in a much larger disc with severe disruptions of morphology. Ras85D^{V12.G37.Scer\UAS} Scer\GAL4^dpp.blk1 and rl^Sem act synergistically to produce a small amount of hyperplastic growth in third instar wing discs. Mutants die as pharate adults at 25[o]C and have deletions of tarsal segments and extra wing vein material along L3.

(Karim and Rubin, 1998)

Suppresses the eye reduction phenotype caused by rpr^GMR.PW. Suppresses the eye reduction phenotype caused by W^GMR.PG.

(Kurada and White, 1998)

Appearance of ectopic photoreceptor cells in the adult eye is suppressed by loss of a functional copy of Jra (Jra¹ or Jra^IA109).

(Kockel et al., 1997)

Suppresses the viability of vn^ddd-13 and proliferation defects in vn^L6.

(Schnepp et al., 1996)

TfIIA-S^E73 suppresses the rough eye phenotype of sev^{S11.T:Hsap\MYC}, phl::tor^12D.hs.sev, Ras85D^V12.sev, rl^Sem and svp^2.sev.

(Zeidler et al., 1996)

Enhancer of the dosage-dependent (two or more copies of P{sev-svp1} or P{sev-svp2}) transformation of cone cells into R7 photoreceptors and at a lower frequency R7 cells into outer photoreceptors.

(Begemann et al., 1995)

Eyes show multiple R7 cells, even in a sev^- mutant background. rl^Sem suppresses the reduced viability associated with phl¹², phl¹ and phl¹⁰⁷, and the eye phenotype of phl¹. Homozygous tll¹ embryos from rl^Sem/+ mothers have a tll mutant phenotype. The extra wing vein phenotype of heterozygotes is enhanced in transheterozygotes with dominant Egfr alleles. Flies heterozygous for Egfr^E3 or Egfr^E1 and rl^Sem have smaller eyes than Egfr^E3 or Egfr^E1 heterozygotes alone.

(Brunner et al., 1994)

Xenogenetic Interactions

Statement

Reference

The ectopic wing vein phenotype seen when Hsap\ATN1^{N917.65Q.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PF is enhanced in rl^Sem heterozygotes.

(Charroux et al., 2006)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

108365

rl^Sem/CyO/Dp(?;2)bw^D, S¹ wg^Sp-1 Ms(2)M¹ bw^D

Notes on Origin

Discoverer

Comments

The mutation in rl^Su23 is identical to that found in rl^Sem.

(Lim et al., 1999)

Phenotypes of rl mutants fall into an allelic series: Df(2R)rl10a/rl¹ >= rl⁹/rl¹ > rl^la8/rl¹ > rl¹⁰/rl¹ > rl¹/rl¹.

(Diaz-Benjumea and Hafen, 1994)

Hyperactivated form of the rl kinase.

(Rusch and Levine, 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

DERK^sem

(Mahalingam et al., 2008)

MAPK^Sem

(Karim and Rubin, 1998)

Sem

(Karim and Rubin, 1998, Roch et al., 1998)

rl/MAPK^Sem

(Begemann et al., 1995)

rl^<up>Sem</up>

(Kim et al., 2012)

rl^SEM

(Tchankouo-Nguetcheu et al., 2014, Baril et al., 2009, Koh et al., 2002, Li et al., 2002, Bai et al., 2001, Lorenzen et al., 2001, Firth et al., 2000, Pazman et al., 2000, Bai et al., 1999)

rl^Sem

(Beck et al., 2015, Tchankouo-Nguetcheu et al., 2014, Fischer et al., 2009, Zeng et al., 2007, Charroux et al., 2006)

rl^sem

(Hall and Verheyen, 2015, Marenda et al., 2006, Boulton et al., 2000, Takatsu et al., 2000)

rolled^Sem

(Karim and Rubin, 1998)

Name Synonyms

Sevenmaker

(Brunner et al., 1994)

rolledSEM

(Jones et al., 2006)

Secondary FlyBase IDs

References (65)

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