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General Information
Symbol
Dmel\rodH4.8
Species
D. melanogaster
Name
FlyBase ID
FBal0014638
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
transposable element insertion site
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Doc insertion in an intron.

Insertion components
Doc{}rodH4.8
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

chromatin & mitotic anaphase

chromatin & mitotic telophase

nuclear chromosome & mitotic anaphase

Detailed Description
Statement
Reference

Incomplete sister chromatid separation during mitosis. Transmission rate of Dp(1;f)J21A through females to progeny is 28%, rod mutations cause a mild increase in transmission. mei-S3321 ord1 double mutant has no effect Dp(1;f)J21A transmission in males.

Strong allele. Lagging chromatids are often observed during anaphase in larval brain cells. Nuclear bridging by strands of chromatin during anaphase/telophase is also common.

% abnormal anaphases: 20.2 % homozygous viable: 25 Mutants show mitotic abnormalities in larval neuroblasts; there is a high frequency of both aneuploid cells and abnormal anaphase figures, with lagging chromatids, anaphase bridges and stretched chromatid arms. Abnormal chromosome behavior also occurs in the second meiotic anaphase in male meiosis, although motile sperm are produced. All surviving homozygous females and 90% of surviving homozygous males are sterile and have roughened eyes, sparse abdominal bristles and notched wings.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The dramatically increased length of the prometaphase/metaphase interval and increase in both mitotic index and metaphase:anaphase ration that is seen in Lis-1G10.14/Lis-1k13209 neuroblasts is not seen if they are also homozygous for rodH4.8, although the centrosome and spindle assembly defects still remain.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Does not contain a P-element at the rod locus despite being isolated in a PM hybrid dysgenesis screen.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)