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General Information
Symbol
Dmel\amosRoi-1
Species
D. melanogaster
Name
FlyBase ID
FBal0014646
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Roi, Roi1
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Inversion between 36A and 37A. The proximal breakpoint is 2.6kb downstream of amos.

Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The ommatidia of amosRoi-1 mutant flies have variable numbers of cone cells (1-6 per ommatidium). The shapes and patterns of packing of these cone cells corresponds to the patterns of packing seen in aggregates of identically sized soap bubbles: a single cone cell is round; clusters of 2-5 cone cells all pack in the pattern primarily observed for a soap bubble aggregate of that number; clusters of 6 cone cells pack in one of the three stable configuration seen for soap bubble aggregates of that number.

Heterozygotes show a severe disruption of the ommatidial lattice in the retina. The ommatidia can contain either more or less than the normal number of photoreceptor cells (for example the small rhabdomeres characteristic of photoreceptor cells R7 and R8 can either be missing or clustered). Pigment cells are often missing, resulting in large clusters of photoreceptors that include the equivalent of 2 to 3 normal ommatidia. R8 precursors are irregularly spaced and show occasional twinning in third larval instar eye discs, and there is disorganised recruitment of other ommatidial cells. Homozygous clones in the retina are smaller than their wild-type twin spots and contain very aberrant photoreceptors with fused or distorted rhabdomeres. Wild-type clones in the retina in a heterozygous background develop into a regular array of normal ommatidia, while the surrounding heterozygous tissue develops into abnormal ommatidia. At the edge of the clone, mosaic ommatidia (containing both wild type and heterozygous photoreceptors) are usually abnormal in structure.

Eye facets of amosRoi-1/+ irregularly rounded, sometimes enlarged; eyes sometimes bulge. RK2A.

Adult eyes are rough with irregular round bulging facets. Variable number of rhabdomeres per ommatidia. Highly variable size and shape of clusters on eye disc.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

amosRoi-1/amos[+] is a suppressor | partially of visible | recessive phenotype of ato1

amosRoi-1/amos[+] is a suppressor of visible | dominant phenotype of roDOM

amosRoi-1/amos[+] is a suppressor of visible phenotype of rohs.PI

amosRoi-1/amos[+] is a suppressor of visible phenotype of roDOM

Other
Phenotype Manifest In
NOT Enhanced by
Statement
Reference

amosRoi-1 has ommatidium phenotype, non-enhanceable by ato1/ato[+]

Suppressed by
Statement
Reference

amosRoi-1 has ommatidium phenotype, suppressible by da[+]/da10

amosRoi-1 has ommatidium phenotype, suppressible | partially by hh[+]/hh8

NOT suppressed by
Statement
Reference

amosRoi-1 has ommatidium phenotype, non-suppressible by ato1/ato[+]

amosRoi-1 has ommatidium phenotype, non-suppressible by dacunspecified

Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

amosRoi-1/amos[+] is a suppressor | partially of eye phenotype of ato1

amosRoi-1/amos[+] is a suppressor of eye phenotype of roDOM

amosRoi-1 is a suppressor | partially of phenotype of DrMio

amosRoi-1/amos[+] is a suppressor of eye phenotype of rohs.PI

amosRoi-1 is a suppressor | partially of phenotype of hhbar3

Additional Comments
Genetic Interactions
Statement
Reference

An amosRoi-1 background enhances the rough eye phenotype found upon expression of fruNP0021 under the control of Scer\GAL4GMR.PF.

A amosRoi-1; amosScer\UAS.cGa mutant background enhances the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4hs.2sev resulting in a lethal phenotype.

The eyes of amosRoi-1/+ ; ato1/ato1 flies can reach up to 1/3 of wild-type size. The ommatidial clusters appear disorganised and contain an abnormal number of photoreceptors, whose rhabdomeres are often elongated and misshapen. R8 cells appear to be present in most if not all ommatidia. hh8 dominantly suppresses the amosRoi-1/+ phenotype; at least 50% of the ommatidia have normal structure and orientation in double heterozygotes. da10/+ almost completely suppresses the amosRoi-1/+ retina phenotype. amosRoi-1 complements lethal dac mutant alleles and the amosRoi-1 rough eye phenotype is insensitive to a reduction in the dosage of the dac gene.

Suppresses the reduced eye phenotype of roDOM, and heat shocked rohs.PI, and restores dpp expression.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (1)
Stocks (103)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (15)