FlyBase Allele Report: Dmel\Polr2A[1]

General Information

Symbol

Dmel\Polr2A¹

Species

D. melanogaster

Name

FlyBase ID

FBal0014658

Feature type

allele

Associated gene

Dmel\Polr2A

Associated Insertion(s)

Carried in Construct

Allele class

amorphic allele - genetic evidence

Mutagen

X ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Brickey and Greenleaf, 1995, Mortin et al., 1988, Mortin and Kaufman, 1982)

Mutagen

X ray

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

Substantial deletion in the 5' region upstream of the RpII215 coding region.

(Brickey and Greenleaf, 1995)

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

lethal

(Wilson and Fabian, 1986)

lethal | recessive

(Krasnoselskaya et al., 1998, Brickey and Greenleaf, 1995, Kim et al., 1994)

lethal - all die before end of larval stage | recessive

(Perrimon et al., 1989)

lethal - all die during embryonic stage

(Mortin and Kaufman, 1982)

some die during embryonic stage

(Mortin and Kaufman, 1982)

some die during larval stage | recessive

(Perrimon et al., 1989)

Phenotype Manifest In

oocyte | germline clone

(Perrimon et al., 1989)

ovariole | germline clone

(Perrimon et al., 1989)

Detailed Description

Statement

Reference

Does not interact with RpII140^wimp maternal effect.

(Parkhurst and Ish-Horowicz, 1991)

Animals die as late embryos. These appear normal at a gross morphological level.

(Mortin and Kaufman, 1982)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Polr2A¹ has lethal phenotype, non-suppressible by Polr2B^S1

(Kim et al., 1994)

Polr2A¹ has lethal phenotype, non-suppressible by Polr2B^S2

(Kim et al., 1994)

Polr2A¹ has lethal phenotype, non-suppressible by Polr2B^S5

(Kim et al., 1994)

Polr2A¹ has lethal phenotype, non-suppressible by Polr2B^S6

(Kim et al., 1994)

Polr2A¹ has lethal phenotype, non-suppressible by Polr2B^S8

(Kim et al., 1994)

Polr2A¹ has lethal phenotype, non-suppressible by Polr2B^S7

(Kim et al., 1994)

Polr2A¹ has lethal phenotype, non-suppressible by Polr2B^S11

(Kim et al., 1994)

Polr2A¹ has lethal phenotype, non-suppressible by Polr2B^S12

(Kim et al., 1994)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

RpII215[+]/Polr2A¹ is a non-enhancer of wing vein | ectopic phenotype of Snr1^E1

(Marenda et al., 2004)

NOT Suppressor of

Statement

Reference

RpII215[+]/Polr2A¹ is a non-suppressor of wing vein | ectopic phenotype of Snr1^E1

(Marenda et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

The recessive lethality of RpII215¹ is not rescued by one copy of RpII140^S1, RpII140^S2, RpII140^S5, RpII140^S6, RpII140^S8, RpII140^S7, RpII140^S11 or RpII140^S12.

(Kim et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

1512

y² ras¹ v¹ Polr2A¹ shi¹/FM7a, Df(1)FM7, l(1)*^*/Dp(1;Y)y⁺v⁺#3

Kyoto

106358

y² ras¹ v¹ Polr2A¹ shi¹/FM7a, Df(1)FM7, l(1)*^*/Dp(1;Y)y⁺v⁺#3

Notes on Origin

Discoverer

Lefevre.

Comments

Maternal germline clonal analysis demonstrates abnormal oogenesis, abnormal postvitellogenic oocytes.

(Perrimon et al., 1989)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

(Voelker et al., 1985)

Polr2A¹

RPII215¹

(Sung et al., 2013)

RpII215¹

(Popodi et al., 2010-)

RpII215^L5

(Brickey and Greenleaf, 1995)

RpIIⁿ

(Mortin and Kaufman, 1982)

Ublⁿ

l(1)L5

(Wilson and Fabian, 1986)

l(1)L5, Ublⁿ

(Mortin et al., 1988)

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

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