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General Information
Symbol
Dmel\Polr2A8
Species
D. melanogaster
Name
FlyBase ID
FBal0014665
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
C20
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

C11566672T

Reported nucleotide change:

C4447T

Amino acid change:

L878F | RpII215-PA

Reported amino acid change:

L878F

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: L878F. Nucleotide substitution: C4447T.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Exhibits the Ubx effect: heterozygotes partially transform the capitellum of the haltere into the wing blade.

Haplospecific lethal. Survives, at least with a low frequency, as a homozygote, but is lethal in hemizygotes.

Mutant flies show resistance to α-amanitin.

Temperature-sensitive mutation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement
Reference

RpII215[+]/Polr2A8 is an enhancer of wing vein | ectopic phenotype of Snr1E1

Additional Comments
Genetic Interactions
Statement
Reference

Marcal1del/Marcal1del RpII2158/+ embryos show a reduced hatching rate compared to controls at 20[o]C.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (9)