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General Information
Symbol
Dmel\Rsps
Species
D. melanogaster
Name
sensitive
FlyBase ID
FBal0014789
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Carried on aberration
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Necessary and sufficient to confer sensitivity to distortion irrespective of its association with an intact second chromosome or one that pairs meiotically with an SD chromosome. An SD chromosome is capable of causing efficient distortion in two Rsps bearing chromosomes within a spermatocyte nucleus.

    sensitive

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    Segregation distortion can occur in the absence of RanGAPSd if flies are homozygous for E(SD)1 : Flies carrying chromosome SD-5[R7] (E(SD)1, Rspi M(SD)1 St(SD)1) / chromosome ReR-5 (E(SD)1 Rsps) exhibit moderate segregation distortion (k=0.74 +/-0.014) against ReR-5. This can be suppressed by the presence of RanβTub85D.PK or Rcc1βTub85D.PK.

    RanGAPSd.tPa induces high levels of segregation distortion in the presence of the SD-5[R7] chromosome (E(SD)1, Rspi, M(SD)1, St(SD)1) over a target homolog chromosome carrying Rspss or Rsps.

    Under certain genotypic conditions, the chromosome carrying the "sensitive" Rsps allele in a RanGapSD heterozygous Rspi/Rsps male can be transmitted to the progeny at frequencies greater than 0.5, or correspondingly, the chromosome carrying the "insensitive" Rspi allele can be distorted with respect to the chromosome carrying the "sensitive" Rsps allele. This "negative segregation distortion" indicates that the relative sensitivity and insensitivity of Rsps and Rspi to distortion in a male are not absolute, but relative, and they may be reversed depending on the residual genotype.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (6)
    Notes on Origin
    Discoverer
    Comments
    Comments

    Rsps is a divisible element.

    The sensitive state of Rsp.

    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (5)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (26)