FlyBase Allele Report: Dmel\Rsp[s]

General Information

Symbol

Dmel\Rsp^s

Species

D. melanogaster

Name

sensitive

FlyBase ID

FBal0014789

Feature type

allele

Associated gene

Rsp

Associated Insertion(s)

Carried in Construct

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

Carried on aberration

C(1;YL)19-3

C(Y;4)cb25-1

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Necessary and sufficient to confer sensitivity to distortion irrespective of its association with an intact second chromosome or one that pairs meiotically with an SD chromosome. An SD chromosome is capable of causing efficient distortion in two Rsp^s bearing chromosomes within a spermatocyte nucleus.

(Brittnacher and Ganetzky, 1989)

sensitive

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

M(SD)¹, Rsp^ss/Rsp^s has male fertile phenotype

(Hiraizumi et al., 1980)

M(SD)¹, Rspⁱ/Rsp^s has male fertile phenotype

(Hiraizumi et al., 1980)

M(Sd)[+]/M(SD)¹, Rsp^ss/Rsp^s has male fertile phenotype

(Hiraizumi et al., 1980)

M(Sd)[+]/M(SD)¹, Rspⁱ/Rsp^s has male fertile phenotype

(Hiraizumi et al., 1980)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Segregation distortion can occur in the absence of RanGAP^Sd if flies are homozygous for E(SD)¹ : Flies carrying chromosome SD-5[R7] (E(SD)¹, Rspⁱ M(SD)¹ St(SD)¹) / chromosome ReR-5 (E(SD)¹ Rsp^s) exhibit moderate segregation distortion (k=0.74 +/-0.014) against ReR-5. This can be suppressed by the presence of Ran^βTub85D.PK or Rcc1^βTub85D.PK.

(Kusano et al., 2002)

RanGAP^Sd.tPa induces high levels of segregation distortion in the presence of the SD-5[R7] chromosome (E(SD)¹, Rspⁱ, M(SD)¹, St(SD)¹) over a target homolog chromosome carrying Rsp^ss or Rsp^s.

(McLean et al., 1994)

Under certain genotypic conditions, the chromosome carrying the "sensitive" Rsp^s allele in a RanGap^SD heterozygous Rspⁱ/Rsp^s male can be transmitted to the progeny at frequencies greater than 0.5, or correspondingly, the chromosome carrying the "insensitive" Rspⁱ allele can be distorted with respect to the chromosome carrying the "sensitive" Rsp^s allele. This "negative segregation distortion" indicates that the relative sensitivity and insensitivity of Rsp^s and Rspⁱ to distortion in a male are not absolute, but relative, and they may be reversed depending on the residual genotype.