A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Allele Dmel\rst6

General Information
SymbolDmel\rst6SpeciesD. melanogaster
NameFlyBase IDFBal0014797
Feature typealleleCreated / Updated2006-08-22/2006-08-22
Associated geneDmel\rst
Allele class
Mutagenethyl methanesulfonate
hide Nature of the Allele
Allele class
Mutagen
Mapped Features and Mutations
Type
Symbol & Location
Additional Notes
References
 
 
 
 
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Progenitor genotype
      Nature of the lesion
      Statement
      Reference
      Disrupts the intracellular domain.
      98bp deletion that severely affects the cytoplasmic domain.
      Assay mode
      Cytology
      Polytene chromosomes normal.
       
      Polytene chromosomes normal.
      hide Phenotypic Data
      hide Phenotypic Class
      hide Phenotype Manifest In
      hide Detailed Description
      Statement
      Reference
      viability normal in both sexes no vt effect
       
      Timing of adult emergence is normal.
      e(faswb)1 rst6 flies have slightly rough eyes.
      No defects in optic chiasm.
      Occasional extra secondary pigment cells within the eye. Low levels of cell death are seen in the larval eye disc leading to a disorganised retinal lattice.
      Spacing of arcs along the posterior of the morphogenetic furrow appears normal.
      Individuals homozygous for Bpt1 and rst6 exhibit no Bpt1 phenotype.
      Rough eye phenotype.
      Severe eye phenotype.
      The total number of sensilla on the antenna are comparable to wild-type controls, but spacing between adjacent sensilla is altered and there are regions where the sense organs appear in tufts. Clusters of 6 to 8 sensilla basiconica often appear to fall into a pit in the epidermis. The total number of sensory founder cells in the antennal disc is comparable to wild type, but the pattern of the founder cells is disorganised. The pattern of apoptotic nuclei in third larval instar antennal discs is no different from wild type.
      Many ectopic interommatidial bristles are visible throughout the interommatidial lattice in mature mutant pupal retinas. Adult eyes have a rough surface with misaligned ommatidial rows.
      Homozygous muscles show thin muscles and sometimes lack muscles entirely in some segments. Furthermore, embryos exhibit muscles in ectopic positions.
      Mutant pupal eye discs do not show elimination of surplus interommatidial (lattice) cells (which occurs in wild-type discs) and disruption of cell sorting is seen.
      In the eye disc of hemizygous rst[6] flies, cell sorting does not occur, leading to an excess of surviving interommatidial precursor cells. In contrast, rst[6]/+ eye discs display no strong sorting defects and only occasionally have supernumerary interommatidial precursor cells.
      hide Interactions
      hide Phenotypic Class
      hide Phenotype Manifest In
      hideEnhanced by
      Statement
      Reference
      hideEnhancer of
      Statement
      Reference
      hide Additional Comments
      hide Genetic Interactions
      Statement
      Reference
      Expression of one copy of X11L[dsRNA.Scer\UAS], driven by Scer\GAL4[GMR.PF], in a rst[6]/+ background leads to severe cell sorting defects in eye discs, similar to those seen in rst[6] homozygotes.
      hide Xenogenetic Interactions
      Statement
      Reference
      hide Complementation & Rescue Data
      Comments
      hide Stocks ( 4 )
      Bloomington
      Kyoto
      hide Notes on Origin
      Discoverer
      hide Synonyms & Secondary IDs ( 6 )
      Reported As
      Symbol Synonym
      rst16172.646
      Name Synonym
      Secondary FlyBase IDs
        hide References ( 23 )
        Generate a list of
        List References by type
        hide Recent research papers ( 1 )
        Vishnu et al., 2006, Dev. Biol. 289(2): 296--307
        The adaptor protein X11Lalpha/Dmint1 interacts with the PDZ-binding domain of the cell recognition protein Rst in Drosophila. [FBrf0190176]