FlyBase Allele Report: Dmel\run[3]

General Information

Symbol

Dmel\run³

Species

D. melanogaster

Name

FlyBase ID

FBal0014848

Feature type

allele

Associated gene

Dmel\run

Associated Insertion(s)

Carried in Construct

Also Known As

run^LB5, runt^LB5, runt³, run3

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

mitomycin C

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Duffy and Gergen, 1991)

Mutagen

mitomycin C

Progenitor genotype

Cytology

Description

5 kb deletion that removes the run transcription unit.

(Duffy and Gergen, 1991)

Deletion that spans the run structural gene.

(Duffy et al., 1991)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell adhesion

(Paré et al., 2014)

abnormal cell polarity | gastrula stage

(Zallen and Wieschaus, 2004)

abnormal cell shape | embryonic stage 6

(Eritano et al., 2020)

abnormal planar polarity

(Paré et al., 2014)

Phenotype Manifest In

cephalic furrow | absent | embryonic stage 6

(Eritano et al., 2020)

epithelial cell | embryonic stage 6

(Eritano et al., 2020)

Detailed Description

Statement

Reference

run³ embryos display cephalic furrow initiation events of "type III+", in which three or more cells undergo shortening simultaneously, and an increase in the number of initiating cells per area unit. But cephalic furrow formation is abrogated.

(Eritano et al., 2020)

run³ mutant embryos lack the second midgut constriction and only form first and third constrictions.

(Fiedler et al., 2015)

Cell intercalation is reduced by more than 30% in run³ mutant embryos, accompanied by slower edge contraction.

(Paré et al., 2014)

Anterior-posterior polarization of cells in the extending germband is partially disrupted in run³ hemizygous embryos.

(Zallen and Wieschaus, 2004)

In run³ null homozygotes the presumptive anal plate is well formed.

(Kuhn et al., 2000)

Hemizygous run³ embryos that are homozygous for run^t14.5 have nearly wild-type segmentation.

(Duffy et al., 1991)

Initially the parasegments have variable development. Later the ftz stripes become limited and a variable pattern of eve stripes survives with irregular boundaries.

(Lawrence and Johnston, 1989)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

run³ is a non-enhancer of lethal | embryonic stage | maternal effect phenotype of Gug^unspecified

(Zhang et al., 2002)

Suppressor of

Statement

Reference

run³ is a suppressor of lethal | female limited phenotype of Myc^dm-1

(Kappes et al., 2011)

run³ is a suppressor of lethal | female limited phenotype of Myc^P0

(Kappes et al., 2011)

run³ is a suppressor of lethal | female limited phenotype of Myc^P1

(Kappes et al., 2011)

Other

Statement

Reference

run³, sc^sisB-1 has lethal | dominant | heat sensitive phenotype

(Duffy and Gergen, 1991)

Phenotype Manifest In

Enhanced by

Statement

Reference

run³ has phenotype, enhanceable by RpS10b^unspecified

(Duffy et al., 1996)

run³ has phenotype, enhanceable by RpL36^B46

(Duffy et al., 1996)

run³ has phenotype, enhanceable by RpL36^y74k24.1

(Duffy et al., 1996)

run³ has phenotype, enhanceable by RpS17^unspecified

(Duffy et al., 1996)

run³ has phenotype, enhanceable by l(2)41Ae^34-4

(Duffy et al., 1996)

run³ has phenotype, enhanceable by Nipped-A¹

(Duffy et al., 1996)

run³ has phenotype, enhanceable by M(1)8F^unspecified

(Duffy et al., 1996)

run³ has phenotype, enhanceable by RpL27A^unspecified

(Duffy et al., 1996)

run³ has phenotype, enhanceable by M(2)31A^unspecified

(Duffy et al., 1996)

run³ has phenotype, enhanceable by RpL38^unspecified

(Duffy et al., 1996)

run³ has phenotype, enhanceable by M(2)53^unspecified

(Duffy et al., 1996)

run³ has phenotype, enhanceable by M(3)65F^unspecified

(Duffy et al., 1996)

run³ has phenotype, enhanceable by M(3)69E^unspecified

(Duffy et al., 1996)

run³ has phenotype, enhanceable by Df(3R)M86D

(Duffy et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

All run³ dm¹ trans-heterozygous female offspring from dm¹ fathers mated to run³ females survive.

Approximately 79% of run³ dm^P0 trans-heterozygous female offspring from dm^P0 fathers mated to run³ mothers survive.

Approximately 89% of run³ dm^P1 trans-heterozygous female offspring from dm^P1 fathers mated to run³ mothers survive.

(Kappes et al., 2011)

Sir2^05327a does not show a dominant synthetic lethal interaction with run³.

(Rosenberg and Parkhurst, 2002)

Females transheterozygous for Df(1)260-1, Df(1)sc19 and Df(1)sc10-1 show a great reduction in viability, some reduction with sc^sisB-1 and no reduction with Df(1)ase-1.

(Duffy and Gergen, 1991)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

56499

y¹ w¹ f¹ run³/FM7a/Dp(1;Y)y⁺mal¹⁰²

Kyoto

107760

y¹ w¹ f¹ run³/FM7a/Dp(1;Y)y⁺mal¹⁰²

Notes on Origin

Discoverer

Baldwin.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

LB5

(Jaynes and Fujioka, 2004)

l(1)LB5

(Lawrence and Johnston, 1989)

run3

(Kim et al., 2022, Rosenberg and Parkhurst, 2002)

run³

(Clarembaux-Badell et al., 2022, Mahadeveraju et al., 2020, Chen et al., 2012, Kuzin et al., 2011, Schroeder et al., 2011, Popodi et al., 2010-, González et al., 2008)

run^LB5

(Zallen and Wieschaus, 2004, Kuhn et al., 2000, Sackerson et al., 1999, Azpiazu et al., 1996, Duffy et al., 1996, Tsai and Gergen, 1995, Wimmer et al., 1995, Tsai and Gergen, 1994, Butler et al., 1992, Duffy and Gergen, 1991, Riddihough and Ish-Horowicz, 1991, Perrimon et al., 1989)

runLB5

(Lawrence and Johnston, 1989)

runt³

(Watson et al., 2011, Bertet et al., 2009)

runt^B5

(Eritano et al., 2020)

runt^LB5

(Fiedler et al., 2015, Vander Zwan et al., 2003, Fujioka et al., 1999, Kramer et al., 1999, Tsai et al., 1998, Duffy et al., 1991, Kania et al., 1990)

Δrunt³

(González et al., 2008)

Name Synonyms

runt3

(Kappes et al., 2011)

runtLB5

(Paré et al., 2014)

Secondary FlyBase IDs

References (38)

Report Sections

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