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General Information
Symbol
Dmel\run3
Species
D. melanogaster
Name
FlyBase ID
FBal0014848
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
runLB5, runtLB5, runt3
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

5 kb deletion that removes the run transcription unit.

Deletion that spans the run structural gene.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

run3 mutant embryos lack the second midgut constriction and only form first and third constrictions.

Cell intercalation is reduced by more than 30% in run3 mutant embryos, accompanied by slower edge contraction.

Anterior-posterior polarization of cells in the extending germband is partially disrupted in run3 hemizygous embryos.

In run3 null homozygotes the presumptive anal plate is well formed.

Hemizygous run3 embryos that are homozygous for runt14.5 have nearly wild-type segmentation.

Initially the parasegments have variable development. Later the ftz stripes become limited and a variable pattern of eve stripes survives with irregular boundaries.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

run3 is a suppressor of lethal | female limited phenotype of Mycdm-1

run3 is a suppressor | partially of lethal | female limited phenotype of MycP0

run3 is a suppressor | partially of lethal | female limited phenotype of MycP1

Other
Statement
Reference

run3, scsisB-1 has lethal | dominant | heat sensitive phenotype

Phenotype Manifest In
Enhanced by
Statement
Reference

run3 has phenotype, enhanceable by RpS10bunspecified

run3 has phenotype, enhanceable by RpL36B46

run3 has phenotype, enhanceable by RpL36y74k24.1

run3 has phenotype, enhanceable by RpS17unspecified

run3 has phenotype, enhanceable by l(2)41Ae34-4

run3 has phenotype, enhanceable by Nipped-A1

run3 has phenotype, enhanceable by M(1)8Funspecified

run3 has phenotype, enhanceable by RpL27Aunspecified

run3 has phenotype, enhanceable by M(2)31Aunspecified

run3 has phenotype, enhanceable by RpL38unspecified

run3 has phenotype, enhanceable by M(2)53unspecified

run3 has phenotype, enhanceable by M(3)65Funspecified

run3 has phenotype, enhanceable by M(3)69Eunspecified

run3 has phenotype, enhanceable by Df(3R)M86D

Additional Comments
Genetic Interactions
Statement
Reference

All run3 dm1 trans-heterozygous female offspring from dm1 fathers mated to run3 females survive.

Approximately 79% of run3 dmP0 trans-heterozygous female offspring from dmP0 fathers mated to run3 mothers survive.

Approximately 89% of run3 dmP1 trans-heterozygous female offspring from dmP1 fathers mated to run3 mothers survive.

Sir205327a does not show a dominant synthetic lethal interaction with run3.

Females transheterozygous for Df(1)260-1, Df(1)sc19 and Df(1)sc10-1 show a great reduction in viability, some reduction with scsisB-1 and no reduction with Df(1)ase-1.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer

Baldwin.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (9)
References (34)