Allele Dmel\run²⁸

General Information
Symbol	Dmel\run²⁸	Species	D. melanogaster
Name		FlyBase ID	FBal0014873
Feature type	allele	Associated gene	Dmel\run
Also Known As	run^YE96, runt^YE96

Allele class	hypomorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (Torres and Sanchez, 1992)
Mutagen	ethyl methanesulfonate
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage \| pair rule expression pattern (Gergen and Wieschaus, 1985)
Phenotype Manifest In
	abdominal segment 1 (Gergen and Wieschaus, 1985, Carroll and Scott, 1986) abdominal segment 3 (Gergen and Wieschaus, 1985) abdominal segment 5 (Gergen and Wieschaus, 1985) abdominal segment 6 (Carroll and Scott, 1986) abdominal segment 7 (Gergen and Wieschaus, 1985) denticle belt (Gergen and Wieschaus, 1985, Carroll and Scott, 1986) mesothoracic segment (Gergen and Wieschaus, 1985) mesothoracic segment \| cell autonomous (Gergen and Wieschaus, 1985) mesothoracic segment \| cell autonomous \| somatic clone (Gergen and Wieschaus, 1985) metathoracic segment (Carroll and Scott, 1986)
Detailed Description
	Statement Reference run¹⁶/shakB^-, run²¹/shakB^- and run²⁸/shakB^- heterozygotes are fully viable and exhibit no neuronal defects. (Baird et al., 1990) Strong allele. (DiNardo and O'Farrell, 1987) Mirror-image duplication of abdominal denticle bands 2, 4, 6 and 8, deletion of odd numbered abdominal bands, dominant defects in T3, A1 and A6. (Carroll and Scott, 1986) The denticle belts of the mesothoracic segment, A1, A3, A5 and A7 are deleted, with the deletion extending through the naked cuticle in front of the denticle belts, and into the posterior half of the remaining denticle belts. The deleted regions are replaced by mirror-image duplications of the remaining pattern elements. (Gergen and Wieschaus, 1985) strong hypomorph
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer	Wieschaus.

Comments
	prd RNA expression has been studied in run²⁸ embryos. (Baumgartner and Noll, 1990) Embryos mosaic for run²⁸ show that the effect of run on segment pattern is largely autonomous. (Gergen and Wieschaus, 1985)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	l(1)YE96 run²⁸ run^YE96 (Colas et al., 1995, Edgar et al., 1994, Torres and Sanchez, 1992, Baumgartner and Noll, 1990, Baird et al., 1990, Perrimon et al., 1989, Miklos et al., 1987, Hiromi and Gehring, 1987, Carroll and Scott, 1986) runt^YE96 (Kramer et al., 1999, Yu and Pick, 1995, DiNardo and O'Farrell, 1987, Gergen and Wieschaus, 1985) YE96 (Zusman et al., 1985)
Name Synonym
Secondary FlyBase IDs

References ( 16 )
Research paper	Kramer et al., 1999, Development 126(1): 191--200 Direct activation of Sex-lethal transcription by the Drosophila runt protein. [FBrf0106053] Colas et al., 1995, Proc. Natl. Acad. Sci. U.S.A. 92(12): 5441--5445 Drosophila 5-HT₂ serotonin receptor: coexpression with fushi-tarazu during segmentation. [FBrf0081644] Yu and Pick, 1995, Mech. Dev. 50(2-3): 163--175 Non-periodic cues generate seven ftz stripes in the Drosophila embryo. [FBrf0080506] Edgar et al., 1994, Development 120(11): 3131--3143 Transcriptional regulation of string (cdc25): a link between developmental programming and the cell cycle. [FBrf0073015] Torres and Sanchez, 1992, Genet. Res. (Camb.) 59(3): 189--198 The segmentation gene runt is needed to activate Sex-lethal, a gene that controls sex determination and dosage compensation in Drosophila. [FBrf0056153] Baird et al., 1990, Genetics 126: 1045--1059 The Passover locus in Drosophila melanogaster: complex complementation and different effects on the giant fiber neural pathway. [FBrf0051915] Baumgartner and Noll, 1990, Mech. Dev. 33: 1--18 Network of interactions among pair-rule genes regulating paired expression during primordial segmentation of Drosophila. [FBrf0052515] Perrimon et al., 1989, Genetics 121: 313--331 Developmental genetics of loci at the base of the X chromosome of Drosophila melanogaster. [FBrf0049891] DiNardo and O'Farrell, 1987, Genes Dev. 1: 1212--1225 Establishment and refinement of segmental pattern in the Drosophila embryo: spatial control of engrailed expression by pair-rule genes. [FBrf0046274] Hiromi and Gehring, 1987, Cell 50: 963--974 Regulation and function of the Drosophila segmentation gene fushi tarazu. [FBrf0045785] Miklos et al., 1987, J. Neurogenet. 4: 1--19 Localization of the genes shaking-B, small optic lobes, sluggish-A, stoned and stress-sensitive-C to a well-defined region on the X-chromosome of Drosophila melanogaster. [FBrf0046783] Carroll and Scott, 1986, Cell 45: 113--126 Zygotically active genes that affect the spatial expression of the fushi tarazu segmentation gene during early Drosophila embryogenesis. [FBrf0043897] Gergen and Wieschaus, 1986, Cell 45: 289--299 Dosage requirements for runt in the segmentation of Drosophila embryos. [FBrf0043901] Gergen and Wieschaus, 1985, Dev. Biol. 109: 321--335 The localized requirements for a gene affecting segmentation in Drosophila: Analysis of larvae mosaic for runt. [FBrf0042365] Zusman et al., 1985, D. I. S. 61: 217--218 Report of new mutants. [FBrf0042290] Wieschaus et al., 1984, Rouxs Arch. Dev. Biol. 193: 296--307 Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. [FBrf0040178]

Allele Dmel\run28

Allele Dmel\run²⁸