Allele Dmel\ry⁵⁰⁶

General Information
Symbol	Dmel\ry⁵⁰⁶	Species	D. melanogaster
Name		FlyBase ID	FBal0015008
Feature type	allele	Created / Updated	2006-08-22/2006-08-22
Associated gene	Dmel\ry

Allele class	amorph, loss of function
Mutagen	γ ray
Nature of the Allele
Allele class	amorph (Lucchesi and Manning, 1988, Dunkov et al., 1991) loss of function (Lindsley and Zimm, 1992)
Mutagen	γ ray (Lindsley and Zimm, 1992)
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	ry⁺⁵ (Reaume et al., 1989, Reaume et al., 1991, Hilliker et al., 1992, Daniels et al., 1985, Sekelsky, 1999.10.10)
Nature of the lesion	Statement Reference Deletion of ry coding sequences. (Lucchesi and Manning, 1988) Deletion of approximately one-third of the coding region. (Reaume et al., 1989) Deletion mutant. (Dunkov et al., 1991) The 3' half of the coding region is deleted. (Reaume et al., 1991) Deletion of two thirds of the 3' end of the gene. (Hughes et al., 1992) Deletion of ry sequences, including at least some of the protein coding region. (Daniels et al., 1985) 3.4 kb deletion between +1.1 and +5.0 kb. (Lindsley and Zimm, 1992) The ry⁵⁰⁶ deletion begins at +1397 (GTGCATTG...) and proceeds through +4885 (...TTATGAAAC). There is an insertion of a single A between the breakpoints (unless this A is a polymorphism on the ry⁺⁵ chromosome at +4885). (Sekelsky, 1999.10.10)
Assay mode
Cytology
Phenotypic Data
Phenotypic Class
	viable (Lucchesi and Manning, 1988) eye color defective (Pitts and Zwiebel, 2001) fertile (DeLotto and Spierer, 1986) chemical sensitive (Hilliker et al., 1992) radiation sensitive (Hilliker et al., 1992)
Phenotype Manifest In
	pigment cell (Pitts and Zwiebel, 2001)
Detailed Description
	Statement Reference Homozygotes are hypersensitive to paraquat, hyperoxia and γ-radiation. ry⁵⁰⁶ Sodⁿ¹ double homozygotes die during late metamorphosis and during the process of eclosion. (Hilliker et al., 1992) The response of ry⁵⁰⁶ mutants to paraquat is similar to wild-type flies. (Wang et al., 2003)
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference ry⁵⁰⁶ has eye color defective phenotype, suppressible by Ccap\Xdh^hs.PP (Pitts and Zwiebel, 2001)
NOT Enhancer of
Statement Reference ry⁵⁰⁶/ry⁵⁰⁶ is a non-enhancer of chemical resistant \| dominant phenotype of puc^E69 (Wang et al., 2003, Wang et al., 2003)
Other
Statement Reference Zwⁿ³, ry⁵⁰⁶ has lethal \| recessive phenotype (Lucchesi and Manning, 1988, Lucchesi and Manning, 1988) Zwⁿ¹, ry⁵⁰⁶ has lethal \| recessive phenotype (Lucchesi and Manning, 1988, Lucchesi and Manning, 1988)
Phenotype Manifest In
Suppressed by
Statement Reference ry⁵⁰⁶ has pigment cell phenotype, suppressible by Ccap\Xdh^hs.PP (Pitts and Zwiebel, 2001)
Additional Comments
Genetic Interactions
Statement Reference The double mutant combination Zwⁿ¹/Y ry⁵⁰⁶/ry⁵⁰⁶ or Zwⁿ³/Y ry⁵⁰⁶/ry⁵⁰⁶ is usually lethal. Escaper Zwⁿ¹/Y ry⁵⁰⁶/ry⁵⁰⁶ flies live for only a few days and appear to be sterile. (Lucchesi and Manning, 1988) The response of puc^E69/+ flies to paraquat is not affected when flies have a ry⁵⁰⁶ genetic background. (Wang et al., 2003)
Xenogenetic Interactions
Statement Reference Expression of Ccap\Xdh^hs.PP using heat shock in ry⁵⁰⁶ animals results in flies with wild-type eye pigmentation. (Pitts and Zwiebel, 2001)
Complementation & Rescue Data
Comments
Stocks ( 1904 )
Bloomington	225 ry⁵⁰⁶ 4159 ry⁵⁰⁶ P{PZ}900 7316 ry⁵⁰⁶ P{FZ}F125 2534 ry⁵⁰⁶ P{Δ2-3}99B 9155 P{A92}P101 ry⁵⁰⁶ 2538 Birmingham; ry⁵⁰⁶ 5770 P{sevroI}1; ry⁵⁰⁶
Kyoto	101745 ry⁵⁰⁶ 105799 ry⁵⁰⁶ 101729 P{SRS3.9}4 ry⁵⁰⁶ 107389 ry⁵⁰⁶ P{Δ2-3}99B 107393 Birmingham; ry⁵⁰⁶
	More stocks available...
Notes on Origin
Discoverer	Gelbart.

Comments
	Dia2 enzyme activity is missing in ry⁵⁰⁶ mutants. (Dunkov et al., 1991)
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	ry⁵⁰⁶ (Radford et al., 2007, Radford et al., 2007)
Name Synonym
Secondary FlyBase IDs

References ( 25 )

Generate a list of	All references relating to this allele ( 25 )

List References by type	Research paper ( 23 ) Personal communication to FlyBase ( 1 ) Book ( 1 )
Recent research papers ( 2 )
	Radford et al., 2007, Genetics 176(1): 63--72 Heteroduplex DNA in meiotic recombination in Drosophila mei-9 mutants. [FBrf0201675] Radford et al., 2007, Genetics 176(1): 53--62 Meiotic recombination in Drosophila Msh6 mutants yields discontinuous gene conversion tracts. [FBrf0201097] Show all research papers ...

Allele Dmel\ry506

Allele Dmel\ry⁵⁰⁶