FlyBase Allele Report: Dmel\salm[1]

General Information

Symbol

Dmel\salm¹

Species

D. melanogaster

Name

FlyBase ID

FBal0015124

Feature type

allele

Associated gene

Dmel\salm

Associated Insertion(s)

Carried in Construct

Also Known As

sal^IIA55, sal¹, sal^2A55, salII^A55, sal^IIA, salm^IIA

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Jurgens and Weigel, 1988)

Mutagen

ethyl methanesulfonate

(Casanova, 1989, Jurgens, 1988, Tearle and Nusslein-Volhard, 1987, Nusslein-Volhard et al., 1984)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with salm^{1st-exon-dsRed})

(Zhang et al., 2014)

lethal (with salm^{1st-intron-dsRed})

(Zhang et al., 2014)

lethal - all die during embryonic stage | recessive

(Frei et al., 1988, Jurgens, 1988)

some die during embryonic stage | recessive

(Frei et al., 1988, Jurgens, 1988)

visible | recessive

(Lunde et al., 1998)

Phenotype Manifest In

abdominal lateral pentascolopidial chordotonal organ lch5 | increased number

(Elstob et al., 2001)

abdominal segment 8

(Kuhn et al., 1995)

abdominal segment 9

(Kuhn et al., 1995)

dorsal row of triple row of wing sensilla | ectopic

(Lunde et al., 1998, Sturtevant et al., 1997)

embryonic/larval posterior spiracle | embryonic stage

(Kuhn et al., 1995)

hypodermal muscle of A1-7 | embryonic stage (with salm^sj154)

(Ou et al., 2021)

indirect flight muscle cell | somatic clone (with Df(2L)salm^FRT)

(Spletter et al., 2015)

macrochaeta

(Lunde et al., 1998)

macrochaeta | ectopic

(Sturtevant et al., 1997)

medial row of triple row of wing sensilla | ectopic

(Lunde et al., 1998, Sturtevant et al., 1997)

posterior crossvein

(Sturtevant et al., 1997)

tracheal dorsal trunk primordium

(Caviglia and Luschnig, 2013)

ventral row of triple row of wing sensilla | ectopic

(Lunde et al., 1998, Sturtevant et al., 1997)

visceral tracheal branch primordium | ectopic

(Caviglia and Luschnig, 2013)

wing & macrochaeta

(Lunde et al., 1998, Sturtevant et al., 1997)

wing vein L2 | ectopic

(Lunde et al., 1998, Sturtevant et al., 1997)

wing vein L5

(Sturtevant et al., 1997)

Detailed Description

Statement

Reference

Homozygous loss of salm in the muscle (generated by inducing the Df(2L)salm^FRT deletion in muscle using UAS-FLP under the control of Scer\GAL4^Mef2.PR, in trans to salm¹) results in complete tubular reversion of the indirect flight muscles.

(Spletter et al., 2015)

Dorsal trunk cells are transformed into visceral branch identity in salm¹ embryos. The tips of the transformed branches contain terminal cells and fusion cells, as in the lateral trunk of wild-type embryos.

(Caviglia and Luschnig, 2013)

Single cell class IV dendrite arborisation (da) neuron clones that are homozygous for salm¹ do not show defects in the establishment or maintenance of dendritic tiling.

(Parrish et al., 2007)

Extra lateral chordotonal organs are formed in mutant embryos, with the number of lateral chordotonal organs in the cluster frequently being 6 or 7 (instead of the wild type 5). The extra chordotonal organs are restricted to the lateral cluster with the other abdominal chordotonal organs (V'ch1, VchAB) remaining wild-type in number.

(Elstob et al., 2001)

Homozygous salm¹ clones between veins L2 and L3 have an ectopic vein L2 fork running within and along the clone boundary. Homozygous salm¹ clones which intersect the wing margin are associated with ectopic islands of triple row bristles.

(Lunde et al., 1998)

Clone on the dorsal surface of the wing between wing vein L2 and L3 causes branching of the wing vein L2 on the presumptive dorsal surface; forked L2 phenotype. The ectopic vein forms within and at the extreme anterior edge of the clone. When the clone extends to the margin ectopic triple row bristles are formed. Clones near the posterior wing edge cause bifurcation of wing vein L5 or the posterior crossvein.

(Sturtevant et al., 1997)

Defects in the identity of posterior segments A8 and A9, distinct posterior spiracles are not formed.

(Kuhn et al., 1995)

Double mutant combinations with cnc^- embryos show additive effects in the head skeleton. The strong dorsal pouch syndrome of Dfd¹⁴ embryos (labral structures are poorly involuted) is suppressed in the double mutant combination (closed oral aperture).

(Mohler et al., 1995)

Anterior prothoracic pattern elements differentiate in the labial segment, two abdomen segments are replaced with thoracic segments.

(Roder et al., 1992)

embryonic lethal. Shows partial homeotic transformation of labium to prothorax and of A9 and 10 toward A8. Point mutants judged to be amorphic or nearly so judging from the phenotype of salm/Df compared with salm/salm. salm; Abd-B double mutants exhibit thoracic structures in parasegments 14 and 15; similarly, salm and Scr seem to act independently on head structures in parasegments 2 and possibly 1.

(Nusslein-Volhard et al., 1984)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

salm¹ has visible | recessive phenotype, suppressible by kni^ri-1

(Lunde et al., 1998)

salm¹ has lethal | embryonic stage phenotype, suppressible by sala^C20-sal

(Frei et al., 1988)

Phenotype Manifest In

Suppressed by

Statement

Reference

salm¹ has wing vein L2 | ectopic phenotype, suppressible by kni^ri-1

(Lunde et al., 1998)

NOT suppressed by

Statement

Reference

salm¹ has dorsal row of triple row of wing sensilla | ectopic phenotype, non-suppressible by kni^ri-1

(Lunde et al., 1998)

salm¹ has medial row of triple row of wing sensilla | ectopic phenotype, non-suppressible by kni^ri-1

(Lunde et al., 1998)

salm¹ has ventral row of triple row of wing sensilla | ectopic phenotype, non-suppressible by kni^ri-1

(Lunde et al., 1998)

Enhancer of

Statement

Reference

salm¹ is an enhancer of leg phenotype of Pc¹⁶

(Landecker et al., 1994)

salm¹ is an enhancer of sex comb phenotype of Pc¹⁶

(Landecker et al., 1994)

salm¹ is an enhancer of leg phenotype of ph-d²

(Landecker et al., 1994)

salm¹ is an enhancer of sex comb phenotype of ph-d²

(Landecker et al., 1994)

salm¹ is an enhancer of leg phenotype of ph-p²

(Landecker et al., 1994)

salm¹ is an enhancer of sex comb phenotype of ph-p²

(Landecker et al., 1994)

Other

Statement

Reference

salm¹, tkv⁴ has tracheal section phenotype

(Bradley and Andrew, 2001)

Additional Comments

Genetic Interactions

Statement

Reference

Most tracheal tip cells adopt the terminal cell fate in salm¹ aop^O199 double mutant embryos.

(Caviglia and Luschnig, 2013)

Embryos doubly mutant for rib¹ and tkv⁴ form only the transverse connectives and visceral branches. The addition of salm^Scer\UAS.cKa and Scer\GAL4^btl.PS to rib¹ embryos does not rescue the dorsal trunk migration phenotype.

(Bradley and Andrew, 2001)

Ectopic L2 forks are not induced by homozygous salm¹ clones in a kni^ri-1 background. Ectopic islands of triple row bristles are induced by salm¹ clones in a kni^ri-1 background.

(Lunde et al., 1998)

Embryonic lethality and the homeotic effects can be rescued by the sala^C20-sal construct, individuals die as crawling larvae.

(Frei et al., 1988)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

salm^A405.1M2

(Wagner-Bernholz et al., 1991)

Not rescued by

salm¹ is not rescued by Scer\GAL4^btl.PS/salm^UAS.cKa

(Bradley and Andrew, 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

3274

salm¹ cn¹ bw¹ speck¹/CyO

Kyoto

106952

salm¹ cn¹ bw¹ speck¹/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

sal^11A55

(Edgar et al., 1994)

sal¹

(Bradley and Andrew, 2001, Elstob et al., 2001, Landecker et al., 1994)

sal^2A55

(Mohler, 1995, Mohler et al., 1995, Wagner-Bernholz et al., 1991)

sal^2a

(Kuhn et al., 1995)

sal^IIA55

(Harbecke and Lengyel, 1995, Kuhnlein et al., 1994, Casanova, 1989, Frei et al., 1988, Jurgens, 1988, Jurgens and Weigel, 1988)

sal^IIA

(Crozatier et al., 1999, Strecker et al., 1992, Tearle and Nusslein-Volhard, 1987)

salII^A55

(Boube et al., 2001, Boube et al., 2000)

salm¹

(Nikonova et al., 2022, Ou et al., 2021, Sarov et al., 2016, Zhang et al., 2014, Caviglia and Luschnig, 2013, Curtis et al., 2013, Christensen and Cook, 2008.4.15, Sanders et al., 2008, Christensen and Cook, 2007.10.29, Parrish et al., 2007, Christensen and Cook, 2006.12.5, Christensen and Cook, 2006.12.5)

salm^IIA

(Lunde et al., 1998, Sturtevant et al., 1997)

Name Synonyms

Secondary FlyBase IDs

References (38)

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