FB2025_01 , released February 20, 2025
Allele: Dmel\salm2
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General Information
Symbol
Dmel\salm2
Species
D. melanogaster
Name
FlyBase ID
FBal0015125
Feature type
allele
Associated gene
Dmel\salm
Associated Insertion(s)
Carried in Construct
Also Known As
salIIB57
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Kuhnlein et al., 1994)
Mutagen
ethyl methanesulfonate
(Jurgens, 1988, Tearle and Nusslein-Volhard, 1987, Nusslein-Volhard et al., 1984)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In mutant embryos the stigmatophore does not form, resulting in a non-protruding but otherwise normal spiracular chamber, with the trachea connected as normal to the spiracle.

      (Hu and Castelli-Gair, 1999)

      Heterozygotes with salmA405.1M2 display a weak salm phenotype.

      (Kuhnlein et al., 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      salm2 has lethal | embryonic stage phenotype, suppressible by salaC20-sal

      (Frei et al., 1988)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Embryonic lethality and the homeotic effects can be rescued by the salaC20-sal construct, individuals die as crawling larvae.

      (Frei et al., 1988)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      salmA405.1M2

      (Wagner-Bernholz et al., 1991)
      Rescued by

      salmA405.1M2/salm2 is rescued by salmC20-sal26

      (Kuhnlein et al., 1994)

      salm2 is rescued by salmC20-sal26

      (Kuhnlein et al., 1994)
      Comments

      salmC20-sal26 rescues the salmA405.1M2/salm2 mutant phenotype. salmC20-sal26 also rescues the homozygous head mutant phenotype and partially rescues the tail defects.

      (Kuhnlein et al., 1994)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      References (11)