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General Information
Symbol
Dmel\Sb70
Species
D. melanogaster
Name
FlyBase ID
FBal0015147
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion of a blood element in the 3' region of Sb, which results in a truncated transcript of approximately 2.8kb.

May have an insertion between -55.5 and -57kb.

Insertion components
blood{}Sb70
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

7% of heterozygotes have a malformed leg phenotype.

Sb1, T(2;3)SbV, and SbSpi are much less severe in phenotype, both in bristle length and frequency and severity of malformation of appendages, than Sb63b and Sb70.

zip interacts to some degree with all Sb dominant mutations.

strong allele homozygous viable

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

Sb70 has visible | dominant phenotype, enhanceable by Rho172O/Rho1[+]

Sb70 has visible | dominant phenotype, enhanceable by Rho1[+]/Rho1k02107b

Sb70 has visible | dominant phenotype, enhanceable by rok[+]/Rok1

Sb70 has visible | dominant phenotype, enhanceable by zip[+]/zipEbr

NOT Enhanced by
Statement
Reference

Sb70 has visible | dominant phenotype, non-enhanceable by Cdc42[+]/Cdc424

Sb70 has visible | dominant phenotype, non-enhanceable by Rac1J11/Rac1[+]

Sb70 has visible | dominant phenotype, non-enhanceable by Rac2314/Rac2[+]

Sb70 has visible | dominant phenotype, non-enhanceable by Cdc42[+]/Cdc423

Enhancer of
Statement
Reference

Sb[+]/Sb70 is an enhancer of visible phenotype of LIMK1D522A.UAS, Scer\GAL4hs.PB

Other
Statement
Reference

Rho172O/Rho1[+], Sb70 has visible | dominant phenotype

Sb[+]/Sb70, Rok2 has visible phenotype

Sb[+]/Sb70, Rok1 has visible | dominant phenotype

Sb[+]/Sb70, Rok1 has visible phenotype

Rho172O, Sb[+]/Sb70 has visible phenotype

Sb[+]/Sb70, zipEbr has visible phenotype

Rho1J3.8, Sb[+]/Sb70 has visible phenotype

Rho172F, Sb[+]/Sb70 has visible phenotype

Rho172F/Rho1[+], Sb70 has visible | dominant phenotype

Sb70, rok[+]/Rok1 has visible | dominant phenotype

RhoGEF204291/RhoGEF2[+], Sb70 has visible | dominant phenotype

RhoGEF21.1/RhoGEF2[+], Sb70 has visible | dominant phenotype

RhoGEF211-3/RhoGEF2[+], Sb70 has visible | dominant phenotype

RhoGEF211-3/RhoGEF2[+], Sb70 has visible phenotype

Sb70, rok[+]/Rok2 has visible | dominant phenotype

E(zip)12-5[+]/E(zip)12-512-5, Sb70 has visible phenotype

Sb70, rok[+]/Rok1 has visible phenotype

E(zip)18-5[+]/E(zip)18-518-5, Sb70 has visible phenotype

E(zip)31-631-6/E(zip)31-6[+], Sb70 has visible phenotype

Rho112-6/Rho1[+], Sb70 has visible phenotype

Sb70, zip33-1/zip[+] has visible phenotype

Rho1J3.8/Rho1[+], Sb70 has visible | dominant phenotype

Sb70, zip[+]/zipEbr has visible | dominant phenotype

Phenotype Manifest In
Enhanced by
Statement
Reference

Sb70 has leg phenotype, enhanceable by LIMK1D522A.UAS/Scer\GAL4hs.PB

Sb70 has leg phenotype, enhanceable by Rho172O/Rho1[+]

Sb70 has leg phenotype, enhanceable by Rho1[+]/Rho1k02107b

Sb70 has leg phenotype, enhanceable by rok[+]/Rok1

Sb70 has leg phenotype, enhanceable by zip[+]/zipEbr

NOT Enhanced by
Statement
Reference

Sb70 has leg phenotype, non-enhanceable by Cdc42[+]/Cdc424

Sb70 has leg phenotype, non-enhanceable by Rac1J11/Rac1[+]

Sb70 has leg phenotype, non-enhanceable by Rac2314/Rac2[+]

Sb70 has leg phenotype, non-enhanceable by Cdc42[+]/Cdc423

Enhancer of
Statement
Reference

Sb[+]/Sb70 is an enhancer of leg phenotype of LIMK1D522A.UAS, Scer\GAL4hs.PB

Other
Statement
Reference

Sb70, zip[+]/zipEbr has wing phenotype

Rho172O/Rho1[+], Sb70 has leg phenotype

Sb[+]/Sb70, Rok1 has wing phenotype

RhoGEF211-3, Sb[+]/Sb70 has leg phenotype

RhoGEF211-3, Sb[+]/Sb70 has wing phenotype

Sb[+]/Sb70, zip33-1 has leg phenotype

Rho112-6, Sb[+]/Sb70 has leg phenotype

Rho112-6, Sb[+]/Sb70 has wing phenotype

Rho172F/Rho1[+], Sb70 has leg phenotype

Rho1E3.10/Rho1[+], Sb70 has leg phenotype

Rho1E3.10/Rho1[+], Sb70 has wing phenotype

RhoGEF204291/RhoGEF2[+], Sb70 has leg phenotype

RhoGEF21.1/RhoGEF2[+], Sb70 has leg phenotype

RhoGEF211-3/RhoGEF2[+], Sb70 has leg phenotype

Sb70, rok[+]/Rok2 has leg phenotype

Rho1J3.8/Rho1[+], Sb70 has leg phenotype

Rho1J3.8/Rho1[+], Sb70 has wing phenotype

Sb70, rok[+]/Rok1 has leg phenotype

Additional Comments
Genetic Interactions
Statement
Reference

The frequency of the malformed leg phenotype seen in Sb70/+ heterozygotes (7%) is increased if the flies are also heterozygous for Rho172O (56%), Rho1k02107b (95%), rok1 (94%) or zipEbr (96%). The frequency of the malformed leg phenotype seen in Sb70/+ heterozygotes (7%) is not increased if the flies are also heterozygous for Rac1J11/+ (2%), Rac2314/+ (8%), Cdc423/+ (7%) or Cdc424/+ (8%). Expression of LIMK1D522A.Scer\UAS under the control of Scer\GAL4hs.PB enhances the frequency of the malformed leg phenotype seen in Sb70/+ heterozygotes from 7% to 84%.

Sb70 shows a strong interaction (at least 50% of double heterozygotes have at least one malformed leg) with the following mutations: Rho112-6, Rho1J3.8, Rho1E3.10, Rho172F, Rho172O, Df(2R)Jp8, rok1, rok2. Sb70 shows a moderate interaction (25-49% of double heterozygotes have at least one malformed leg) with the following mutations: RhoGEF211-3, Df(2R)Jp1, E(zip)18-518-5, E(zip)31-631-6, zip33-1 and E(zip)12-512-5. Sb70 shows a weak interaction (5-24% of double heterozygotes have at least one malformed leg) with the following mutations: RhoGEF21.1, RhoGEF204291. Sb70 shows no interaction with Pkn3 or Pkn06736 (assayed in terms of a malformed leg phenotype). Sb70 shows a strong interaction (at least 50% of double heterozygotes have at least one malformed wing) with the following mutations: Rho1E3.10, Rho1J3.8 and zipEbr. Sb70 shows a strong interaction (at least 50% of double heterozygotes have at least one malformed wing) with the following mutations: Rho112-6. Sb70 shows a moderate interaction (25-49% of double heterozygotes have at least one malformed wing) with the following mutations: rok1 and RhoGEF211-3. Sb70 shows a weak interaction (5-24% of double heterozygotes have at least one malformed wing) with the following mutations: E(zip)12-512-5, E(zip)18-518-5 and E(zip)31-631-6.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (7)