Allele Dmel\Sb^sbd-1

General Information
Symbol	Dmel\Sb^sbd-1	Species	D. melanogaster
Name		FlyBase ID	FBal0015151
Feature type	allele	Associated gene	Dmel\Sb
Also Known As	sbd¹

Allele class	hypomorphic allele - genetic evidence
Mutagen	spontaneous
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (Gotwals and Fristrom, 1991)
Mutagen	spontaneous (Gotwals and Fristrom, 1991)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Spillmann and Nothiger, 1978) visible (with Sb^sbd-201) (Bayer et al., 2003) visible \| recessive (Gotwals and Fristrom, 1991)
Phenotype Manifest In
	leg (with Sb^sbd-201) (Bayer et al., 2003)
Detailed Description
	Statement Reference 10% of Sb^sbd-201/Sb^sbd-1 animals have a malformed leg phenotype. (Bayer et al., 2003) Sb^sbd-1, Sb^sbd-2 and Sb^sbd-207 have much milder phenotypes than other 'sbd' alleles. They are viable and not malformed as homozygotes. (Appel, 1995) Short tapered bristles and malformed appendages. zip interacts very weakly with Sb recessive mutations. (Gotwals and Fristrom, 1991) Bristles short but usually slightly longer than in Sb¹/+. One or both wings often shortened and crumpled at base. Tibia and femur often shortened, thickened, and bowed. sbd genotypes interact synergistically with br genotypes to exaggerate reductions in wing length and short gnarled legs (Beaton et al., FBrf0048216). Viability somewhat low. RK2. homozygous viable
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement Reference Df(2R)Jp1/+, Sb^sbd-1/Sb^sbd-201 has visible phenotype (Bayer et al., 2003) Df(2R)Jp8/+, Sb^sbd-1/Sb^sbd-201 has visible phenotype (Bayer et al., 2003) Df(2R)Jp8/+, Sb^sbd-1 has visible \| dominant phenotype (Bayer et al., 2003) E(zip)12-5[+]/E(zip)12-5^12-5, Sb^sbd-1/Sb^sbd-201 has visible phenotype (Bayer et al., 2003) E(zip)12-5^12-5, Sb^sbd-1/Sb^sbd-201 has visible phenotype (Bayer et al., 2003) E(zip)18-5[+]/E(zip)18-5^18-5, Sb^sbd-1/Sb^sbd-201 has visible phenotype (Bayer et al., 2003) E(zip)18-5^18-5, Sb^sbd-1/Sb^sbd-201 has visible phenotype (Bayer et al., 2003) E(zip)31-6^31-6, Sb^sbd-1/Sb^sbd-201 has visible phenotype (Bayer et al., 2003) E(zip)31-6^31-6/E(zip)31-6[+], Sb^sbd-1/Sb^sbd-201 has visible phenotype (Bayer et al., 2003) Rho1^12-6, Sb^sbd-1/Sb^sbd-201 has visible phenotype (Bayer et al., 2003) Rho1^12-6/Rho1[+], Sb^sbd-1/Sb^sbd-201 has visible phenotype (Bayer et al., 2003) Rho1^E3.10, Sb^sbd-1/Sb^sbd-201 has visible phenotype (Bayer et al., 2003) Rho1^E3.10/Rho1[+], Sb^sbd-1/Sb^sbd-201 has visible phenotype (Bayer et al., 2003) Rho1^J3.8, Sb^sbd-1/Sb^sbd-201 has visible phenotype (Bayer et al., 2003) Rho1^J3.8/Rho1[+], Sb^sbd-1/Sb^sbd-201 has visible phenotype (Bayer et al., 2003) RhoGEF2^1.1, Sb^sbd-1/Sb^sbd-201 has visible phenotype (Bayer et al., 2003) RhoGEF2^1.1/RhoGEF2[+], Sb^sbd-1/Sb^sbd-201 has visible phenotype (Bayer et al., 2003) RhoGEF2^4.1, Sb^sbd-1/Sb^sbd-201 has visible phenotype (Bayer et al., 2003) RhoGEF2^4.1/RhoGEF2[+], Sb^sbd-1/Sb^sbd-201 has visible phenotype (Bayer et al., 2003) RhoGEF2^11-3, Sb^sbd-1/Sb^sbd-201 has visible phenotype (Bayer et al., 2003) RhoGEF2^11-3/RhoGEF2[+], Sb^sbd-1/Sb^sbd-201 has visible phenotype (Bayer et al., 2003) RhoGEF2⁰⁴²⁹¹, Sb^sbd-1/Sb^sbd-201 has visible phenotype (Bayer et al., 2003) RhoGEF2⁰⁴²⁹¹/RhoGEF2[+], Sb^sbd-1/Sb^sbd-201 has visible phenotype (Bayer et al., 2003) Sb^sbd-1/Sb^sbd-201, rok[+]/rok¹ has visible phenotype (Bayer et al., 2003) Sb^sbd-1/Sb^sbd-201, rok[+]/rok² has visible phenotype (Bayer et al., 2003) Sb^sbd-1/Sb^sbd-201, rok¹ has visible phenotype (Bayer et al., 2003) Sb^sbd-1/Sb^sbd-201, rok² has visible phenotype (Bayer et al., 2003) Sb^sbd-1/Sb^sbd-201, zip^33-1/zip[+] has visible phenotype (Bayer et al., 2003) Sb^sbd-1/Sb^sbd-201, zip^33-1 has visible phenotype (Bayer et al., 2003)
Phenotype Manifest In
Other
Statement Reference Df(2R)Jp1/+, Sb^sbd-1/Sb^sbd-201 has leg phenotype (Bayer et al., 2003) Df(2R)Jp8/+, Sb^sbd-1/Sb^sbd-201 has leg phenotype (Bayer et al., 2003) Df(2R)Jp8/+, Sb^sbd-1 has leg phenotype (Bayer et al., 2003) E(zip)12-5[+]/E(zip)12-5^12-5, Sb^sbd-1/Sb^sbd-201 has leg phenotype (Bayer et al., 2003) E(zip)12-5^12-5, Sb^sbd-1/Sb^sbd-201 has leg phenotype (Bayer et al., 2003) E(zip)18-5[+]/E(zip)18-5^18-5, Sb^sbd-1/Sb^sbd-201 has leg phenotype (Bayer et al., 2003) E(zip)18-5^18-5, Sb^sbd-1/Sb^sbd-201 has leg phenotype (Bayer et al., 2003) E(zip)31-6^31-6, Sb^sbd-1/Sb^sbd-201 has leg phenotype (Bayer et al., 2003) E(zip)31-6^31-6/E(zip)31-6[+], Sb^sbd-1/Sb^sbd-201 has leg phenotype (Bayer et al., 2003) Rho1^12-6, Sb^sbd-1/Sb^sbd-201 has leg phenotype (Bayer et al., 2003) Rho1^12-6/Rho1[+], Sb^sbd-1/Sb^sbd-201 has leg phenotype (Bayer et al., 2003) Rho1^E3.10, Sb^sbd-1/Sb^sbd-201 has leg phenotype (Bayer et al., 2003) Rho1^E3.10/Rho1[+], Sb^sbd-1/Sb^sbd-201 has leg phenotype (Bayer et al., 2003) Rho1^J3.8, Sb^sbd-1/Sb^sbd-201 has leg phenotype (Bayer et al., 2003) Rho1^J3.8/Rho1[+], Sb^sbd-1/Sb^sbd-201 has leg phenotype (Bayer et al., 2003) RhoGEF2^1.1, Sb^sbd-1/Sb^sbd-201 has leg phenotype (Bayer et al., 2003) RhoGEF2^1.1/RhoGEF2[+], Sb^sbd-1/Sb^sbd-201 has leg phenotype (Bayer et al., 2003) RhoGEF2^4.1, Sb^sbd-1/Sb^sbd-201 has leg phenotype (Bayer et al., 2003) RhoGEF2^4.1/RhoGEF2[+], Sb^sbd-1/Sb^sbd-201 has leg phenotype (Bayer et al., 2003) RhoGEF2^11-3, Sb^sbd-1/Sb^sbd-201 has leg phenotype (Bayer et al., 2003) RhoGEF2^11-3/RhoGEF2[+], Sb^sbd-1/Sb^sbd-201 has leg phenotype (Bayer et al., 2003) RhoGEF2⁰⁴²⁹¹, Sb^sbd-1/Sb^sbd-201 has leg phenotype (Bayer et al., 2003) RhoGEF2⁰⁴²⁹¹/RhoGEF2[+], Sb^sbd-1/Sb^sbd-201 has leg phenotype (Bayer et al., 2003) Sb^sbd-1/Sb^sbd-201, rok[+]/rok¹ has leg phenotype (Bayer et al., 2003) Sb^sbd-1/Sb^sbd-201, rok[+]/rok² has leg phenotype (Bayer et al., 2003) Sb^sbd-1/Sb^sbd-201, rok¹ has leg phenotype (Bayer et al., 2003) Sb^sbd-1/Sb^sbd-201, rok² has leg phenotype (Bayer et al., 2003) Sb^sbd-1/Sb^sbd-201, zip^33-1/zip[+] has leg phenotype (Bayer et al., 2003) Sb^sbd-1/Sb^sbd-201, zip^33-1 has leg phenotype (Bayer et al., 2003)
Additional Comments
Genetic Interactions
Statement Reference Sb^sbd-1 shows a weak interaction (5-24% of double heterozygotes have at least one malformed leg) with the following mutations: Df(2R)Jp8. Sb^sbd-201/Sb^sbd-2 shows a moderate interaction (25-49% of double mutants have at least one malformed leg) with the following mutations: Rho1^J3.8/+ and Rho1^E3.10/+. Sb^sbd-201/Sb^sbd-2 shows a weak interaction (5-24% of double mutants have at least one malformed leg) with the following mutations: Df(2R)Jp8/+. Pkn⁰⁶⁷³⁶ shows a weak dominant enhancement of leg malformation in Sb^sbd-201/Sb^sbd-1 flies. Pkn³ shows a weak dominant enhancement of leg malformation in Sb^sbd-201/Sb^sbd-1 flies. Sb^sbd-201/Sb^sbd-1 shows a strong interaction (at least 50% of double mutants have at least one malformed leg) with the following mutations: Rho1^J3.8/+, Rho1^E3.10/+, Df(2R)Jp8/+, Df(2R)Jp1/+, Rho1^12-6/+. Sb^sbd-201/Sb^sbd-1 shows a moderate interaction (25-49% of double mutants have at least one malformed leg) with the following mutations: E(zip)18-5^18-5/+, E(zip)31-6^31-6/+, zip^33-1/+, RhoGEF2^11-3/+. Sb^sbd-201/Sb^sbd-1 shows a weak interaction (5-24% of double mutants have at least one malformed leg) with the following mutations: RhoGEF2^1.1/+, RhoGEF2^4.1/+, RhoGEF2⁰⁴²⁹¹/+, rok¹/+, rok²/+ and E(zip)12-5^12-5/+. (Bayer et al., 2003)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially complements	Sb^sbd-17 (Spillmann and Nothiger, 1978) Sb^sbd-32 (Spillmann and Nothiger, 1978)
Fails to complement	Sb^sbd-12 (Spillmann and Nothiger, 1978) Sb^sbd-13 (Spillmann and Nothiger, 1978) Sb^sbd-18 (Spillmann and Nothiger, 1978) Sb^sbd-35 (Spillmann and Nothiger, 1978) Sb^sbd-43 (Spillmann and Nothiger, 1978)
Comments	Complements the lethality but not the bristle phenotype of Sb^sbd-17 and Sb^sbd-32. (Spillmann and Nothiger, 1978)
Stocks ( 21 )
Bloomington	3474 Ubx^9.22 Sb^sbd-1/TM1 3473 Ubx^9.22 Ubx^Cbx-1 Sb^sbd-1/TM1 1771 Kg^V red¹ Sb^sbd-1/TM3, Sb¹ 609 st¹ Sb^sbd-1 e^s ro¹ ca¹ 2990 Df(3L)Cat, kni^ri-1 Sb^sbd-1 e^*/TM3, Ser¹ 2458 st¹ Sb^sbd-1 e¹ ro¹ dco²/TM6B, Tb¹ 1536 In(1)z^ae(bx), z^ae(bx); Sb^sbd-1 ss¹ Ubx^bx-34e/TM1
Kyoto	107056 Ubx^9.22 Sb^sbd-1/TM1 106007 st¹ Sb^sbd-1 e^s ro¹ ca¹ 107511 Df(3L)Cat, kni^ri-1 Sb^sbd-1 e^*/TM3, Ser¹ 107342 st¹ Sb^sbd-1 e¹ ro¹ dco²/TM6B, Tb¹ 102075 y¹ ; Dp(1;3)sc^J4 RpS17⁴ Sb^sbd-1 Ubx^bx-34e / TM1
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Notes on Origin
Discoverer	Sturtevant, 1926.

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	Sb^r Sb^sbd-1 sbd¹ (Bayer et al., 2003, Appel, 1995, Gotwals and Fristrom, 1991, Spillmann and Nothiger, 1978, )
Name Synonym
Secondary FlyBase IDs

References ( 6 )
Research paper	Bayer et al., 2003, Genetics 165(3): 1417--1432 Genetic interactions between the RhoA and Stubble-stubbloid loci suggest a role for a type II transmembrane serine protease in intracellular signaling during Drosophila imaginal disc morphogenesis. [FBrf0167640] Gotwals and Fristrom, 1991, Genetics 127: 747--759 Three neighboring genes interact with the Broad-Complex and the Stubble-stubbloid locus to affect imaginal disc morphogenesis in Drosophila. [FBrf0054179] Spillmann and Nothiger, 1978, D. I. S. 53: 164--165 Cytology, genetics and lethality patterns of homozygous lethal mutations in the sbd region. [FBrf0031288] Dobzhansky, 1930, Z. indukt. Abstamm.- u. VererbLehre 54: 427--457 The manifold effects of the genes stubble and stubbloid in Drosophila melanogaster. [FBrf0002097] Stern, 1929, Biol. Zentbl. 49: 261--290 Uber die additive Wirkung multipler Allele. [FBrf0001800]
Personal communication to FlyBase	Appel, 1995, Sb. Sb. [FBrf0077943]

Allele Dmel\Sbsbd-1

Allele Dmel\Sb^sbd-1