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General Information
Symbol
Dmel\Sbsbd-201
Species
D. melanogaster
Name
FlyBase ID
FBal0015157
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
sbd201
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

A16143756G

Reported nucleotide change:

A2583G

Amino acid change:

H573R | Sb-PA; H573R | Sb-PB

Reported amino acid change:

H572R

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: R572H.

Nucleotide substitution: A2583G.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Sbsbd-201 does not enhance the bristle phenotype of the Sbsbd-2 allele.

Homozygotes have a malformed leg phenotype.

100% of Sbsbd-201 homozygotes have a malformed leg phenotype. 10% of Sbsbd-201/Sbsbd-1 animals have a malformed leg phenotype. 1% of Sbsbd-201/Sbsbd-2 animals have a malformed leg phenotype.

First difference from wild type evident at around 40 hours of pupal development, when the number of actin filament bundles becomes abruptly reduced, then disorganised at the tip accounting for the resulting frayed bristle ends.

Short tapered bristles and malformed appendages. zip interacts very weakly with Sb recessive mutations.

homozygous viable

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement
Reference
Phenotype Manifest In
Other
Statement
Reference

E(zip)18-5[+]/E(zip)18-518-5, Sbsbd-1/Sbsbd-201 has leg phenotype

E(zip)31-631-6/E(zip)31-6[+], Sbsbd-1/Sbsbd-201 has leg phenotype

E(zip)12-5[+]/E(zip)12-512-5, Sbsbd-1/Sbsbd-201 has leg phenotype

Additional Comments
Genetic Interactions
Statement
Reference

Sbsbd-201 interacts with brunspecified or zipunspecified to produce flies with severely malformed legs.

Pkn06736 shows a weak dominant enhancement of leg malformation in Sbsbd-201/Sbsbd-1 flies. Pkn3 shows a weak dominant enhancement of leg malformation in Sbsbd-201/Sbsbd-1 flies. Sbsbd-201/Sbsbd-1 shows a strong interaction (at least 50% of double mutants have at least one malformed leg) with the following mutations: Rho1J3.8/+, Rho1E3.10/+, Df(2R)Jp8/+, Df(2R)Jp1/+, Rho112-6/+. Sbsbd-201/Sbsbd-1 shows a moderate interaction (25-49% of double mutants have at least one malformed leg) with the following mutations: E(zip)18-518-5/+, E(zip)31-631-6/+, zip33-1/+, RhoGEF211-3/+. Sbsbd-201/Sbsbd-1 shows a weak interaction (5-24% of double mutants have at least one malformed leg) with the following mutations: RhoGEF21.1/+, RhoGEF24.1/+, RhoGEF204291/+, rok1/+, rok2/+ and E(zip)12-512-5/+.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Partially rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (7)