FB2021_01, released Feb 18, 2021

Allele: Dmel\sbr17

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General Information
Symbol
Dmel\sbr17
Species
D. melanogaster
Name
FlyBase ID
FBal0015181
Feature type
allele
Associated gene
Dmel\sbr
Associated Insertion(s)
Carried in Construct
Also Known As
ms(1)v7
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Geer et al., 1983)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Cytology
      Nature of the lesion
      Statement
      Reference
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Semilethal: viability 11%.

      (Zhimulev et al., 1987)

      The testes of hemizygous males are largely filled with cysts at the spermatocyte and early spermatid stages. Many of the cysts containing primary spermatocytes appear to be degenerating. Spermatid maturation is evident in some cysts, although many axonemes are incomplete, lacking the central microtubules or degenerating at an early stage. The axonemal sheath is not completely formed in some cases, and consequently mitochondrial derivatives are associated with cytoplasmic membranes. Induction of paracrystalline material in the mitochondrial derivatives is seen. Spermatid elongation does not proceed very far.

      (Dybas et al., 1983)

      Mutation blocks gene functions that are critical to the development of both reproductive and non-reproductive tissues. Genetic lesions evident prior to meiosis in the male gametes.

      (Geer et al., 1983)

      11% survival male-sterile

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      MSV7
      (Geer et al., 1983)
      ms(1)v7
      (Dybas et al., 1983, Geer et al., 1983)
      msv7
      sbr17
      sbrmsv7
      (Zhimulev et al., 1987)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)