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General Information
Symbol
Dmel\sc1
Species
D. melanogaster
Name
FlyBase ID
FBal0015189
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

gypsy insertion within an enhancer of the ac-sc complex.

Insertion of a gypsy element.

Insertion of gypsy element.

gypsy at 1.9 to 2.4; (Carramolino, Ruiz-Gomez, Guerrero, Campuzano, and Modolell (1982) and Campuzano, Carramolino, Cabrera, Ruiz-Gomez, Villares, Boronat and Modolell (1985). 0 defined as the more distal EcoRI site within the scS2 molecular deficiency; positive values extend to the left.)

Insertion components
gypsy{}sc1
Carried on aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

sc1 mutant adults do not display changes in the number of scutellar bristles, as compared to controls.

sc1 mutants completely lack scutellar bristles. sc1 mutant 'rescue' flies that express either scScer\UAS.cQa or scSA.Scer\UAS.cQa under the control of Scer\GAL4cv-c-C5 do not lack scutellar macrochaetae (although their number is decreased compared to wild-type) but in addition they also display ectopic short bristles on the scutellum.

The scutellar bristle fate show temperature dependence in sc1 flies, with the probably of sensory bristle fate being inversely proportional to the temperature.

Homozygotes exhibit loss of a third to half of the wing margin chemoreceptors. Double mutants with ctL32 exhibit an extreme wing phenotype lacking almost all the chemoreceptors and mechanoreceptors.

y2/y59b flies carrying sc1 on the y2 chromosome have a y2 phenotype.

The number of bractless bristles on the basitarsi of the second legs is reduced.

Flies show a loss or reduction in the number of scutellar, anterior dorsocentral, first and second orbital, ocellar and some other bristles.

scFah/sc1 flies show only an occasional absence of postvertical or ocellar bristles.

Causes loss or marked reduction in number of scutellar, coxal, ocellar, first and second orbital, anterior notopleural, postvertical, tergital and sternal bristles. Bristle sockets missing; bristle cells absent 19 hr after pupation, when normally present (Lees and Waddington, 1942; Lees and Waddington, 1943). Suppressed by su(Hw) and su(Hw)2. RK1. Revertable by X rays (Green, 1961).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

sc[+]/sc1 is a suppressor of visible | dominant | adult stage phenotype of lncRNA:SMRGM

sc[+]/sc1 is a suppressor of visible | dominant | adult stage phenotype of E(spl)mβ-HLH12-11

ac1/sc1 is a suppressor of visible | heat sensitive phenotype of HC2.hs

Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

sc1 has scutellar bristle | heat sensitive phenotype, enhanceable by sensE1/sensm1

sc1 has scutellar bristle | heat sensitive phenotype, enhanceable by sensE1/sensm2

sc1 has scutellar bristle | heat sensitive phenotype, enhanceable by sensE1/sensm1m2

sc1 has scutellar bristle | heat sensitive phenotype, enhanceable by mir-9a[+]/mir-9aunspecified

Suppressed by
Statement
Reference

sc1 has phenotype, suppressible by su(sc)ru3

sc1 has phenotype, suppressible by su(sc)ru1

sc1 has phenotype, suppressible by su(sc)ru2

sc1 has phenotype, suppressible by su(Hw)u1

sc1 has phenotype, suppressible by su(Hw)u2

Suppressor of
Statement
Reference

sc[+]/sc1 is a suppressor of scutellar bristle | increased number phenotype of lncRNA:SMRGM

sc[+]/sc1 is a suppressor of wing margin bristle | ectopic phenotype of h41/h[+], ttkrM730

ac1/sc1 is a suppressor of wing vein | ectopic | heat sensitive phenotype of HC2.hs

ac1/sc1 is a suppressor of wing | heat sensitive phenotype of HC2.hs

Other
Additional Comments
Genetic Interactions
Statement
Reference

Flies carrying either sensm1, sensm2 or sensm1m2 in a sensE1 background show enhanced temperature dependence of the scutellar bristle phenotype (loss of scutellar bristles) of sc1 flies compared to controls carrying sens+t18.1 in a sc1 sensE1 background.

mir-9aunspecified/+ enhances the temperature dependence of the scutellar bristle phenotype (loss of scutellar bristles) of sc1 flies.

The addition of sc1/Y to h41/+, ttkrM730/+ animals leads to an almost complete suppression of the ectopic margin bristle phenotype.

The phenotype is affected by mod(mdg4)ul; the ocellar, first and second orbital, and postvertical bristles are present, while the scutellar bristles are lost completely.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments

The loss of scutellar macrochaetae characteristic for sc1 mutant adults is partially rescued by expression of either scScer\UAS.cQa or scSA.Scer\UAS.cQa (but not scSD.Scer\UAS.cQa) under the control of Scer\GAL4cv-c-C5, which however also results in formation of ectopic short bristles on the scutellum.

Images (1)
Stocks (105)
Notes on Origin
Discoverer

Bridges, 22nd Jan. 1916.

Arose with: dw-sc1.

Comments
Comments

See Campuzano et al., Cell 40:327--338 .

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (33)