Open Close
General Information
Symbol
Dmel\sc4
Species
D. melanogaster
Name
FlyBase ID
FBal0015193
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Breakpoint is 7 kb 3' of the sc transcribed region.

kb 25.8 to 24.0; (Carramolino, Ruiz-Gomez, Guerrero, Campuzano, and Modolell (1982) and Campuzano, Carramolino, Cabrera, Ruiz-Gomez, Villares, Boronat and Modolell (1985). 0 defined as the more distal EcoRI site within the scS2 molecular deficiency; positive values extend to the left.)

Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

More than 90% of flies lack the anterior orbital, anterior notopleural, humeral, postvertical, ocellar, presutural, anterior postalar, anterior supraalar, scutellar and posterior postalar bristles. More than 10% of flies lack the posterior supraalar bristles.

Anterior notopleural macrochaetae are removed.

Levels of sc protein are much lower than wild type, accumulation in clusters is still detectable. The PNP, APA and PSA notum macrochaetae are present.

The number of bractless bristles on the basitarsi of the second legs is reduced. A number of bristles with split shafts are seen.

The sc4d campaniform sensilla are missing in 90-100% of hemizygous flies.

Lacks most of the notum macrochaetae. sc RNA was much less abundant than wild type.

The presence of an X-chromosome carrying the In(1)sc4 inversion in abo mothers produces an enhancement of the abo maternal effect. A zygotic effect is also seen resulting in the lethality of the progeny homozygous for abo and In(1)sc4. Authors imply that effect is due to the proximal breakpoint in In(1)sc4 affecting the function of the ABO-X locus.

Extreme scute. Bristles of head, except anterior verticals, absent. Only posterior notopleurals and alars remain on sides of mesothorax; abdominals, ventrals, coxals, and scutellars also missing. Slight variegation for Hw. RK1A.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference

sc4 has phenotype, enhanceable by emc[+]/emcD

Suppressed by
Statement
Reference

sc4 has phenotype, suppressible | partially by emc1/emc11

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (8)
Notes on Origin
Discoverer

Agol, 1928.

Induced on: yunspecified.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (20)