410bp deletion removing the codons for the C-terminal 113 Sce amino acids as well as the intron and 12 nucleotides of the 3' untranslated region downstream of the termination codon.
Deletion of 410bp that removes the codons for the C-terminal 113 amino acids, a small intron and 12 nucleotides of the 3' untranslated region after the termination codon.
410bp deletion removing the codons for the C-terminal 113 Sce amino acids as well as the intron and 12 nucleotides of the 3' untranslated region downstream of the termination codon.
lethal (with Df(3R)IR16)
Eye discs composed predominantly of homozygous cells (generated using the FLP/cell-lethal method) are overgrown.
Homozygous neuroblast clones in the third larval instar central brain and ventral ganglion are dramatically reduced in size compared to control clones and none of the mutant clones show mitotic activity, in contrast to control clones.
Homozygous Sce1/Sce1 germline mutant females mated to Sce1 males produce embryos with an identical phenotype as when crossed to Df(3R)IR16 males, suggesting that Sce1 is a null allele.
Somatic mitotic clones of Sce1 are associated with the formation of multicyst egg chambers containing several oocytes, disorganized encapsulation in germarial region 3, and abnormally long interfollicular stalks containing from 10 to over 50 cells. In some cases, a continuous cable of somatic cells can be observed lying along one side of the follicles. These defects are always associated with the presence of mutant cells, but the very few of these cells suffice to create a very abnormal stalk. No excess of polar follicle cells is associated with these clones.
Sce1/+ suppresses the telomeric position effect (TPE) of P{hsp26-pt-T}39C-5, P{hsp26-pt-T}39C-27, P{hsp26-pt-T}39C-31 and P{wA}4-4.
Homozygous embryos derived from homozygous female germ line clones show transformation of all thoracic and abdominal segments into nearly perfect copies of the eighth abdominal segment.
Embryonic lethal or semi-lethal when heterozygous with ph-d2. Unhatched larvae carry segmentation defects or polarity defects.
Suppression of the Su(z)2hs.PS and Pschs.PS phenotypes.
A dominant enhancer of Abd-B in the bithorax complex. Sce1/Sce1 zygotes from Sce1/+ mothers die as first instar larvae with weak posteriorly directed transformations, i.e., A7 displays some A8 characteristics. Heterozygous offspring normal. Sce1/Sce1 embryos from clones of homozygous oocytes produced by pole-cell transplantation display extreme posteriorly directed segmental transformation. Ventral setal belts of all abdominal and thoracic segments transformed toward A8; head involution blocked; abdominal type denticle belts also found anterior to T1 in the presumptive labial and maxillary segments; in addition an extensive belt of abdominal denticles of unknown derivation forms on the anterodorsal surface of the embryo. Keilin's organs and ventral pits suppressed in thoracic segments; wart-like sensilla normally found in A8 formed anteriorally as far as A2. Tracheal branches in A1-7 resemble those normally found more posteriorly. Sce1/+ offspring from homozygous germ line clones in the mothers may survive to adulthood or die as pharate adults; they show patches of tissue transformed toward A8.
Dominant enhancer of Abd-B. Very weak posteriorly directed transformations.
Sce1 has tumorigenic | somatic clone phenotype, suppressible | somatic clone by domeΔCYT.UAS/Scer\GAL4Act.PU
Sce1 has tumorigenic | somatic clone phenotype, suppressible | somatic clone by Scer\GAL4Act.PU/Socs36EUASp.cCa
Sce[+]/Sce1 is an enhancer of visible | adult stage phenotype of Marcal1UAS.cBa, Scer\GAL4Tub.PU
Sce[+]/Sce1 is an enhancer of visible | adult stage phenotype of Hsap\SMARCAL1UAS.cBa, Scer\GAL4Bx-MS1096
Sce1 is a suppressor | partially of eye color defective phenotype of wph-p.lac+3/w1118
Sce1 is a suppressor of eye color defective phenotype of wT81
Sce[+]/Sce1 is a non-suppressor of increased cell death phenotype of RYBPUAS.cBa, Scer\GAL4nub-AC-62
RYBPKG08683, Sce1 has visible | dominant phenotype
Sce1, ph-d2 has lethal | embryonic stage phenotype
Sce1 has sex comb | ectopic phenotype, suppressible | partially by vtd80Fh-36
Sce1 has eye disc | somatic clone phenotype, suppressible | somatic clone by domeΔCYT.UAS/Scer\GAL4Act.PU
Sce1 has eye disc | somatic clone phenotype, suppressible | somatic clone by Scer\GAL4Act.PU/Socs36EUASp.cCa
Sce1 has neuroblast | somatic clone phenotype, suppressible by Scer\GAL4αTub84B.PL/BacA\p35UAS.cHa
Sce1 has embryonic abdominal segment | rescuable maternal effect phenotype, suppressible | partially by Scer\GAL4prd.RG1/Mmus\Ring1UAS.Tag:MYC
Sce1 has sex comb | ectopic phenotype, non-suppressible by Nipped-B407
Sce[+]/Sce1 is an enhancer of wing vein | adult stage phenotype of Marcal1UAS.cBa, Scer\GAL4Tub.PU
Sce[+]/Sce1 is an enhancer of wing vein | adult stage phenotype of Hsap\SMARCAL1UAS.cBa, Scer\GAL4Bx-MS1096
Sce[+]/Sce1 is a suppressor | partially of adult mesothoracic segment | ectopic phenotype of E(z)Trm
Sce[+]/Sce1 is a suppressor | partially of adult metathoracic segment phenotype of E(z)Trm
Sce[+]/Sce1 is a suppressor of adult prothoracic segment phenotype of E(z)Trm
Sce1 is a suppressor of phenotype of Su(z)2hs.PS
Sce[+]/Sce1 is a non-suppressor of wing disc | third instar larval stage phenotype of RYBPUAS.cBa, Scer\GAL4nub-AC-62
RYBPKG08683, Sce1 has adult abdominal segment 5 phenotype
RYBPKG08683, Sce1 has sex comb | ectopic phenotype
RYBPKG08683, Sce1 has mesothoracic leg phenotype
RYBPKG08683, Sce1 has metathoracic leg phenotype
The formation of ectopic wing veins observed in adult flies expressing Marcal1Scer\UAS.cBa under the control of Scer\GAL4tub.PU is exacerbated by combination with a single copy of Sce1.
Expression of domeΔCYT.Scer\UAS under the control of Scer\GAL4Act.PU reduces the overgrowth of Sce1 mutant eye discs.
Expression of Socs36EScer\UAS.P\T.cCa under the control of Scer\GAL4Act.PU suppresses the overgrowth of Sce1 mutant eye discs.
The increased apoptosis seen in Scer\GAL4nub-AC-62 RYBPScer\UAS.cBa wing discs is unaffected in a Sce1/+ background.
68% of RYBPKG08683/RYBPKG08683 ; Sce1/+ males show depigmentation of the fifth abdominal segment. 42% of the males have sex combs on the T2 or T3 legs.
The addition of heterozygous Sce1 can suppress the Pairing sensitive silencing effect seen in wMcp.10, wMcp.13, wMcp.scs'.12:15, wMcp.scs'.14 and wMcp.y.scs'.1. The addition of heterozygous Sce1 has no effect on the Pairing sensitive silencing effect seen in wMcp.11, wMcp.13, and wMcp.scs'.11. The addition of heterozygous Sce1 has no effect on the Pairing sensitive silencing effect seen in wMcp.scs'.11 (P{Mcp-w#11}16/+, P{Mcp-w#11}102/+) or the eye colour of wMcp.scs'.21/ywe.Mcp.1 and wMcp.y.scs'.1/ywe.Mcp.2 double heterozygous insertions. The addition of heterozygous Sce1 strongly suppresses the Pairing sensitive silencing effect seen in wMcp.scs'.14/wMcp.13 (P{Mcp-w#14}AP-2stummelbein/+, P{Mcp-w#13}116/+) and double heterozygous insertions.
Strong suppressor of eye pigment phenotype of wT81.
The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1Scer\UAS.cBa under the control of Scer\GAL4Bx-MS1096 is exacerbated by combination with a single copy of Sce1.
Expression of Mmus\Ring1Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4prd.RG1 rescues the cuticle phenotype of embryos lacking both maternal and zygotic Sce function (homozygous Sce1 embryos derived from females carrying homozygous Sce1 germ-line clones) in the Scer\GAL4prd.RG1 expression domains.
Df(3R)BSC499/Sce1 is rescued by Scer\GAL4arm.PS/SceUAS.C.Tag:FLAG
Sce1 is rescued by SceUAS.Tag:MYC/Scer\GAL4arm.PS
Sce1 is partially rescued by Scer\GAL4prd.RG1/SceUAS.Tag:MYC
Silencing of Scer\GAL4-BXD genes is dependent on Pc group gene function, in mutant embryos silencing is lost.