FB2025_01 , released February 20, 2025
Allele: Dmel\Scm1
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General Information
Symbol
Dmel\Scm1
Species
D. melanogaster
Name
FlyBase ID
FBal0015265
Feature type
allele
Associated gene
Dmel\Scm
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Lindsley and Zimm, 1992, Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      larval abdominal segment 1

      (Lindsley and Zimm, 1992)

      larval abdominal segment 1 | germline clone

      (Lindsley and Zimm, 1992)

      larval abdominal segment 2

      (Lindsley and Zimm, 1992)

      larval abdominal segment 2 | ectopic

      (Lindsley and Zimm, 1992)

      larval abdominal segment 2 | germline clone

      (Lindsley and Zimm, 1992)

      larval abdominal segment 3

      (Lindsley and Zimm, 1992)

      larval abdominal segment 3 | ectopic

      (Lindsley and Zimm, 1992)

      larval abdominal segment 3 | germline clone

      (Lindsley and Zimm, 1992)

      larval abdominal segment 4

      (Lindsley and Zimm, 1992)

      larval abdominal segment 4 | ectopic

      (Lindsley and Zimm, 1992)

      larval abdominal segment 4 | germline clone

      (Lindsley and Zimm, 1992)

      larval abdominal segment 5

      (Lindsley and Zimm, 1992)

      larval abdominal segment 5 | ectopic

      (Lindsley and Zimm, 1992)

      larval abdominal segment 5 | germline clone

      (Lindsley and Zimm, 1992)

      larval abdominal segment 6

      (Lindsley and Zimm, 1992)

      larval abdominal segment 6 | ectopic

      (Lindsley and Zimm, 1992)

      larval abdominal segment 6 | germline clone

      (Lindsley and Zimm, 1992)

      larval abdominal segment 7

      (Lindsley and Zimm, 1992)

      larval abdominal segment 7 | ectopic

      (Lindsley and Zimm, 1992)

      larval abdominal segment 7 | germline clone

      (Lindsley and Zimm, 1992)

      larval abdominal segment 8 | ectopic

      (Lindsley and Zimm, 1992)

      larval abdominal segment 8 | ectopic | germline clone

      (Lindsley and Zimm, 1992)

      larval mesothoracic segment | germline clone

      (Lindsley and Zimm, 1992)

      larval metathoracic segment | germline clone

      (Lindsley and Zimm, 1992)

      larval prothoracic segment | germline clone

      (Lindsley and Zimm, 1992)
      Detailed Description
      Statement
      Reference

      Shows no dominant effect on telomeric Position Effect Variegation (PEV) in stocks carrying a variegating w+mW.hs allele at the telomeres of the second and third chromosomes.

      (Cryderman et al., 1999)

      Homozygous embryos show posteriorly directed transformations; A1 resembles A2 and A2-7 transformed into more posterior segments, head and thorax normal. Pcl1 Scm1 double homozygotes exhibit transformation of all segments toward A8; Keilin's organs retained in thoracic segments; head involution does not occur; prominent abdominal denticle band seen on dorsal surface of head. Homozygous embryos derived from transplanted homozygous maternal germ-cell precursors display A8 morphology in all thoracic and abdominal segments; head seems to resemble that of Pcl1 Scm1 double homozygotes produced by heterozygous mothers; heterozygous adults from homozygous oocytes show patchy transformations of A4 to A5 and of A6 and A7 to A8; similar transformation infrequently seen in heterozygous offspring of heterozygous mothers.

      (Lindsley and Zimm, 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Statement
      Reference

      Df(2L)TW3/Df(2L)TW201, Scm1 has cephalopharyngeal skeleton phenotype

      (Landecker et al., 1994)

      Df(2L)TW3/Df(2L)TW201, Scm1 has larval abdominal segment 7 phenotype

      (Landecker et al., 1994)

      Df(2L)TW3/Df(2L)TW201, Scm1 has larval abdominal segment 1 phenotype

      (Landecker et al., 1994)

      Df(2L)TW3/Df(2L)TW201, Scm1 has larval abdominal segment 6 phenotype

      (Landecker et al., 1994)

      Df(2R)cn83c/Df(2R)CA53, Scm1 has abdominal 4 ventral denticle belt phenotype

      (Landecker et al., 1994)

      Df(2R)cn83c/Df(2R)CA53, Scm1 has abdominal 5 ventral denticle belt phenotype

      (Landecker et al., 1994)

      Df(2R)cn83c/Df(2R)CA53, Scm1 has abdominal 3 ventral denticle belt phenotype

      (Landecker et al., 1994)

      Df(2R)cn83c/Df(2R)CA53, Scm1 has abdominal 6 ventral denticle belt phenotype

      (Landecker et al., 1994)

      Df(2R)cn83c/Df(2R)CA53, Scm1 has abdominal 7 ventral denticle belt phenotype

      (Landecker et al., 1994)

      Pcl1, Scm1 has larval abdominal segment 4 phenotype

      (Lindsley and Zimm, 1992)

      Pcl1, Scm1 has larval abdominal segment 7 phenotype

      (Lindsley and Zimm, 1992)

      Pcl1, Scm1 has larval abdominal segment 1 phenotype

      (Lindsley and Zimm, 1992)

      Pcl1, Scm1 has larval abdominal segment 2 phenotype

      (Lindsley and Zimm, 1992)

      Pcl1, Scm1 has larval abdominal segment 3 phenotype

      (Lindsley and Zimm, 1992)

      Pcl1, Scm1 has larval abdominal segment 5 phenotype

      (Lindsley and Zimm, 1992)

      Pcl1, Scm1 has larval abdominal segment 6 phenotype

      (Lindsley and Zimm, 1992)

      Pcl1, Scm1 has larval abdominal segment 8 | ectopic phenotype

      (Lindsley and Zimm, 1992)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Df(2L)TW3/Df(2L)TW201; Scm1/+ embryos have severe head defects including almost complete loss of the cephalopharyngeal skeleton, show partial transformation of the 1st abdominal segment to a more posterior segment, and show transformation of the 6th and 7th abdominal segments towards the 8th abdominal segment. Df(2R)CA53/Df(2R)cn83c; Scm1/+ embryos lack terminal structures and are U-shaped. Denticle belts of the 3rd to 7th abdominal segments are transformed posteriorly.

      (Landecker et al., 1994)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      E502
      (Lindsley and Zimm, 1992)
      Scm01
      (Cryderman et al., 1999)
      Scm1
      ScmE502
      (Tearle and Nusslein-Volhard, 1987)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)