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General Information
Symbol
Dmel\Scm4
Species
D. melanogaster
Name
FlyBase ID
FBal0015268
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
ScmXF24
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
complex substitution
Comment:

251bp at the 3' end of Scm are deleted and replaced with 4 nucleotides (CTGA). As a result, the final 49 amino acids of Scm are deleted and replaced with 26 novel amino acids.

Inserted_sequence:

CTGA

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Deletion of the C-terminal 49 amino acids.

Approximately 200bp deletion, plus insertion of 4 nucleotides (CTGA), within the 3' region of the Scm transcription unit, at the 3' end of the ORF. The C-terminal 49 amino acids of Scm protein, including most of the SPM domain, are removed and replaced by 26 novel amino acids encoded by extension of the open reading frame into the 3' UTR.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygotes die during the embryonic or first larval instar stages.

Strong allele.

Pc3 Scm4 heterozygotes have an extreme wing to haltere transformation. This phenotype is normalised towards wild-type in flies also carrying a Ubx mutation in the coding region or abx regulatory region.

Heterozygous males are viable and often show ectopic sex comb teeth. Mild suppressor of z1 eye colour.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

Scm4 is an enhancer of visible | dominant | homeotic phenotype of Pc3

Suppressor of
Statement
Reference
Other
Statement
Reference
Phenotype Manifest In
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

Scm4/Scm[+] is a suppressor of eye phenotype of Hsap\MECP2UAS.FL, Scer\GAL4GMR.PU

Scm4/Scm[+] is a suppressor of eye phenotype of Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU

Scm4 is a suppressor of phenotype of z1

Additional Comments
Genetic Interactions
Statement
Reference

No significant modification of the number of sex combs is seen in Scm4/+ corto420/+ double heterozygotes compared to Scm4/+ single heterozygotes.

Dominantly enhances the homeotic phenotypes of Pc3/+ adults. ph-p409 males that are also heterozygous for Scm4 show partial lethality.

Xenogenetic Interactions
Statement
Reference

The addition of Scm4 increases the rate of leg to wing disc transdetermination to 11.0%

Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Weak derepression of en expression.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (12)