FlyBase Allele Report: Dmel\Scm[D1]

General Information

Symbol

Dmel\Scm^D1

Species

D. melanogaster

Name

FlyBase ID

FBal0015270

Feature type

allele

Associated gene

Dmel\Scm

Associated Insertion(s)

Carried in Construct

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen

X ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Campbell et al., 1995, Gindhart and Kaufman, 1995, Cheng et al., 1994, Simon et al., 1992, McKeon and Brock, 1991)

loss of function allele

(Bornemann et al., 1998, Wu et al., 1989)

Mutagen

X ray

(Bornemann et al., 1998)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

Frameshift mutation, deleting the SPM domain.

(Bornemann et al., 1998)

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

decreased cell number | somatic clone

(Bello et al., 2007)

homeotic

(Morimoto et al., 2016)

lethal | recessive

(Bornemann et al., 1998, Wu et al., 1989)

lethal - all die before end of larval stage

(Breen and Duncan, 1986)

mitotic cell cycle defective | somatic clone

(Bello et al., 2007)

some die during larval stage

(Breen and Duncan, 1986)

suppressor of variegation | dominant, with P{SUPor-P.PRE#6}4

(Mallin et al., 1998)

suppressor of variegation | dominant, with P{SUPor-P.PRE#6}69

(Mallin et al., 1998)

suppressor of variegation | dominant, with P{SUPor-P.PRE#6}69M1

(Mallin et al., 1998)

suppressor of variegation | dominant, with P{SUPor-P.PRE#6}69M2

(Mallin et al., 1998)

suppressor of variegation | dominant, with P{SUPor-P.PRE#6}69M3

(Mallin et al., 1998)

visible | dominant | homeotic

(Mollaaghababa et al., 2001, Ruhf et al., 2001)

visible | homeotic

(Klymenko and Muller, 2004)

Phenotype Manifest In

Detailed Description

Statement

Reference

Scm^D1/+ males display a homeotic transformation of the mesothoracic legs into prothoracic legs manifesting as extra sex combs.

(Morimoto et al., 2016)

Homozygous neuroblast clones in the third larval instar central brain and ventral ganglion are dramatically reduced in size compared to control clones and show a dramatic reduction in mitotic activity.

(Bello et al., 2007)

Cuticles of Scm^D1 mutant clone larvae show complete homeotic transformation of all segments into copies of the eight abdominal segment and are indistinguishable from Scm^D1 trx^E2 double and esc⁶ single mutants.

(Klymenko and Muller, 2004)

Somatic mitotic clones of Scm^D1 cause the formation of multicyst egg chambers and giant interfollicular stalks.

(Narbonne et al., 2004)

13% of heterozygotes show transformation of abdominal segment A4 to A5 (extra black pigmentation is seen on the fourth abdominal tergite in males). 6% of heterozygotes show transformation of abdominal segment A6 to A7 (males have a reduced sixth abdominal tergite). No extra sex combs are seen in heterozygotes.

(Mollaaghababa et al., 2001)

Transformation of second to first leg.

(Ruhf et al., 2001)

Homozygotes die during the embryonic or first larval instar stages. Homozygous embryos derived from homozygous female germ line clones have all segments transformed towards the eighth abdominal segment.

(Bornemann et al., 1998)

Mutation does not affect the level of w expression in ph-p^lac+3 flies.

(Fauvarque et al., 1995)

In z¹ w^zm strain mutation causes reduction of eye pigmentation.

(Georgiev, 1994)

Embryonic lethal or semi-lethal when heterozygous with ph-d². Unhatched larvae carry segmentation defects or polarity defects.

(McKeon et al., 1994)

Embryos doubly mutant for Psc^Arp.1 and Scm^D1 show strong posteriorly directed segmental transformations. There is severe erosion of the ventral setae in the second and third thoracic segments, any setae present on these segments appear to be primarily or entirely abdominal. Ectopic Fell hairs are seen in more than 75% of cases.

(Adler et al., 1991)

Homeotic transformation of the prothoracic through the seventh abdominal segments to the eighth abdominal state (Breen, Dev Biol 118:442 ).

(Wu et al., 1989)

Transformation of A6 and A7 toward A8.

(Breen and Duncan, 1986)

enhancer of Ubx Cbx

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scm^D1 has visible | dominant phenotype, enhanceable by psq[+]/psq^unspecified

(Huang et al., 2002)

NOT Enhanced by

Statement

Reference

Scm^D1 has visible | homeotic phenotype, non-enhanceable by dom¹⁴/dom[+]

(Ruhf et al., 2001)

Suppressed by

Statement

Reference

Scm^D1 has homeotic phenotype, suppressible | partially by Marcal1[+]/Marcal1^del

(Morimoto et al., 2016)

Enhancer of

Statement

Reference

Scm^D1/Scm[+] is an enhancer of visible | dominant | homeotic phenotype of ash1¹⁷, trx^B11/trx[+]

(Gildea et al., 2000)

Scm^D1 is an enhancer of visible | dominant | homeotic phenotype of Pc³

(Bornemann et al., 1998)

Scm^D1/Scm[+] is an enhancer of visible | recessive | homeotic phenotype of mxc^M1

(Saget et al., 1998)

NOT Enhancer of

Statement

Reference

Scm^D1/Scm[+] is a non-enhancer of visible | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

Scm^D1/Scm[+] is a non-enhancer of visible | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

Scm^D1 is a non-enhancer of visible phenotype of BEAF-32^UAS.cYa, Scer\GAL4^GMR.PS

(Yamaguchi et al., 2001)

Suppressor of

Statement

Reference

Scm^D1/Scm[+] is a suppressor of visible phenotype of E2f1^{dsRNA.UAS.cJa}, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Scm^D1/Scm[+] is a suppressor | partially of visible phenotype of E2f1^{dsRNA.UAS.cJa}, Scer\GAL4^ptc-559.1

(Ji et al., 2012)

Scm^D1/Scm[+] is a suppressor of eye color defective phenotype of Hsap\MECP2^R294X.UAS, Scer\GAL4^GMR.PU

(Cukier et al., 2008)

Scm^D1 is a suppressor of eye color defective phenotype of w^{4.Ubx.bxd:pbx.ΔBC1}

(Tillib et al., 1999)

Scm^D1 is a suppressor of eye color defective phenotype of w^{4.Ubx.bxd:pbx.ΔBC3-PHO2}

(Tillib et al., 1999)

Scm^D1 is a suppressor of eye color defective phenotype of w^{4.Ubx.bxd:pbx.ΔBC3-PHO1}

(Tillib et al., 1999)

Scm^D1 is a suppressor of eye color defective phenotype of w^{4.Ubx.bxd:pbx.ΔBC3-PHO1-2}

(Tillib et al., 1999)

Scm^D1 is a suppressor of eye color defective phenotype of w^T81

(Netter et al., 1998)

Scm^D1 is a suppressor of visible phenotype of ct^n2s

(Melnikova et al., 1996)

Scm^D1 is a suppressor of visible phenotype of ct^pN2s

(Melnikova et al., 1996)

NOT Suppressor of

Statement

Reference

Scm^D1/Scm[+] is a non-suppressor of visible | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

Scm^D1/Scm[+] is a non-suppressor of visible | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

Scm^D1 is a non-suppressor of visible phenotype of BEAF-32^UAS.cYa, Scer\GAL4^GMR.PS

(Yamaguchi et al., 2001)

Other

Statement

Reference

Marcal1^del, Scm^D1 has lethal phenotype

(Morimoto et al., 2016)

Scm^Suz302/Scm^D1, Sfmbt¹ has tumorigenic | somatic clone phenotype

(Grimm et al., 2009)

Scm^D1, corto⁴²⁰ has visible phenotype

(Lopez et al., 2001)

Scm^D1, corto[+]/corto⁴²⁰ has visible phenotype

(Lopez et al., 2001)

Hsc70-4^54.1, Scm^D1 has visible | dominant | homeotic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Scm^D1 has visible | dominant | homeotic phenotype

(Mollaaghababa et al., 2001)

Scm^D1, ash1²² has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Scm^D1/Scm[+], ash1²² has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Sce^D1, Scm^D1 has partially lethal | dominant phenotype

(Bornemann et al., 1998)

Scm^D1, ph-p⁴⁰⁹ has partially lethal phenotype

(Bornemann et al., 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scm^D1 has sex comb | ectopic phenotype, enhanceable by gpp[+]/gpp^1A

(Shanower et al., 2005)

Scm^D1 has sex comb | ectopic phenotype, enhanceable by gpp[+]/gpp^X

(Shanower et al., 2005)

Scm^D1 has sex comb | ectopic phenotype, enhanceable by gpp[+]/gpp^XXV

(Shanower et al., 2005)

Scm^D1 has sex comb | ectopic phenotype, enhanceable by gpp[+]/gpp⁸

(Shanower et al., 2005)

Scm^D1 has leg phenotype, enhanceable by psq[+]/psq^unspecified

(Huang et al., 2002)

Scm^D1 has sex comb | ectopic phenotype, enhanceable by psq[+]/psq^unspecified

(Huang et al., 2002)

Scm^D1 has phenotype, enhanceable by mxc^M1

(Docquier et al., 1996)

NOT Enhanced by

Statement

Reference

Scm^D1 has mesothoracic leg phenotype, non-enhanceable by dom¹⁴/dom[+]

(Ruhf et al., 2001)

Suppressed by

Statement

Reference

Scm^D1 has sex comb phenotype, suppressible | partially by Marcal1[+]/Marcal1^del

(Morimoto et al., 2016)

Scm^D1 has neuroblast | somatic clone phenotype, suppressible by Scer\GAL4^αTub84B.PL/BacA\p35^UAS.cHa

(Bello et al., 2007)

Enhancer of

Statement

Reference

Scm^D1/Scm[+] is an enhancer of adult metathoracic segment phenotype of ash1¹⁷, trx^B11/trx[+]

(Gildea et al., 2000)

Scm^D1 is an enhancer of phenotype of Abd-B^Fab7-24

(Mihaly et al., 1997)

Scm^D1 is an enhancer of phenotype of Abd-B^Fab7-33

(Mihaly et al., 1997)

Scm^D1 is an enhancer of phenotype of Abd-B^Fab7-14

(Mihaly et al., 1997)

Scm^D1 is an enhancer of phenotype of Abd-B^Fab7-32

(Mihaly et al., 1997)

Scm^D1 is an enhancer of phenotype of Abd-B^Fab7-P14.1

(Mihaly et al., 1997)

Scm^D1 is an enhancer of phenotype of Abd-B^Fab7-19

(Mihaly et al., 1997)

Scm^D1 is an enhancer of phenotype of Abd-B^Fab7-3

(Mihaly et al., 1997)

Scm^D1 is an enhancer of phenotype of Abd-B^Fab7-P6.1

(Mihaly et al., 1997)

Scm^D1 is an enhancer of phenotype of Abd-B^Fab7-28

(Mihaly et al., 1997)

Scm^D1 is an enhancer of phenotype of Abd-B^Fab7-2

(Mihaly et al., 1997)

Scm^D1 is an enhancer of phenotype of Abd-B^Fab7-P18.1

(Mihaly et al., 1997)

Scm^D1 is an enhancer of phenotype of mxc^M1

(Docquier et al., 1996)

NOT Enhancer of

Statement

Reference

Scm^D1/Scm[+] is a non-enhancer of wing vein | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

Scm^D1/Scm[+] is a non-enhancer of wing vein | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

Scm^D1/Scm[+] is a non-enhancer of eye phenotype of Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU

(Cukier et al., 2008)

Scm^D1/Scm[+] is a non-enhancer of wing vein | ectopic phenotype of Snr1^E1

(Marenda et al., 2004)

Scm^D1 is a non-enhancer of eye phenotype of CycE^JP

(Brumby et al., 2002)

Scm^D1 is a non-enhancer of eye phenotype of BEAF-32^UAS.cYa, Scer\GAL4^GMR.PS

(Yamaguchi et al., 2001)

Suppressor of

Statement

Reference

Scm^D1/Scm[+] is a suppressor of eye phenotype of E2f1^{dsRNA.UAS.cJa}, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Scm^D1/Scm[+] is a suppressor | partially of 1st posterior cell phenotype of E2f1^{dsRNA.UAS.cJa}, Scer\GAL4^ptc-559.1

(Ji et al., 2012)

Scm^D1/Scm[+] is a suppressor of eye phenotype of Hsap\MECP2^UAS.FL, Scer\GAL4^GMR.PU

(Cukier et al., 2008)

Scm^D1/Scm[+] is a suppressor | partially of adult mesothoracic segment | ectopic phenotype of E(z)^Trm

(Bajusz et al., 2001)

Scm^D1/Scm[+] is a suppressor | partially of adult metathoracic segment phenotype of E(z)^Trm

(Bajusz et al., 2001)

Scm^D1/Scm[+] is a suppressor of adult prothoracic segment phenotype of E(z)^Trm

(Bajusz et al., 2001)

Scm^D1 is a suppressor of pigment cell phenotype of w^{4.Ubx.bxd:pbx.ΔBC1}

(Tillib et al., 1999)

Scm^D1 is a suppressor of pigment cell phenotype of w^{4.Ubx.bxd:pbx.ΔBC3-PHO2}

(Tillib et al., 1999)

Scm^D1 is a suppressor of pigment cell phenotype of w^{4.Ubx.bxd:pbx.ΔBC3-PHO1}

(Tillib et al., 1999)

Scm^D1 is a suppressor of pigment cell phenotype of w^{4.Ubx.bxd:pbx.ΔBC3-PHO1-2}

(Tillib et al., 1999)

Scm^D1 is a suppressor of phenotype of z¹

(Bornemann et al., 1998)

Scm^D1 is a suppressor of wing phenotype of ct^n2s

(Melnikova et al., 1996)

Scm^D1 is a suppressor of wing phenotype of ct^pN2s

(Melnikova et al., 1996)

NOT Suppressor of

Statement

Reference

Scm^D1/Scm[+] is a non-suppressor of wing vein | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

Scm^D1/Scm[+] is a non-suppressor of wing vein | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

Scm^D1/Scm[+] is a non-suppressor of eye phenotype of Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU

(Cukier et al., 2008)

Scm^D1/Scm[+] is a non-suppressor of wing vein | ectopic phenotype of Snr1^E1

(Marenda et al., 2004)

Scm^D1 is a non-suppressor of eye phenotype of CycE^JP

(Brumby et al., 2002)

Scm^D1 is a non-suppressor of eye phenotype of BEAF-32^UAS.cYa, Scer\GAL4^GMR.PS

(Yamaguchi et al., 2001)

Scm^D1 is a non-suppressor of phenotype of w^{4.Ubx.bxd:pbx.ΔBC2}

(Tillib et al., 1999)

Scm^D1 is a non-suppressor of phenotype of w^{4.Ubx.bxd:pbx.ΔBC3}

(Tillib et al., 1999)

Other

Statement

Reference

Scm^Suz302/Scm^D1, Sfmbt¹ has wing disc | somatic clone phenotype

(Grimm et al., 2009)

Scm^D1, corto⁴²⁰ has sex comb | ectopic phenotype

(Lopez et al., 2001)

Scm^D1, corto[+]/corto⁴²⁰ has sex comb | ectopic phenotype

(Lopez et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Scm^D1 has adult abdominal segment 5 | ectopic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Scm^D1 has adult abdominal segment 6 phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Scm^D1 has adult abdominal segment 7 | ectopic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Scm^D1 has abdominal tergite 4 | male phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Scm^D1 has abdominal tergite 6 | male phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Scm^D1 has adult abdominal segment 4 phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Scm^D1 has adult abdominal segment 5 | ectopic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Scm^D1 has adult abdominal segment 6 phenotype

(Mollaaghababa et al., 2001)

Hsc70-4^54.1, Scm^D1 has adult abdominal segment 7 | ectopic phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Scm^D1 has abdominal tergite 4 | male phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Scm^D1 has abdominal tergite 6 | male phenotype

(Mollaaghababa et al., 2001)

Hsc70-4[+]/Hsc70-4^54.1, Scm^D1 has adult abdominal segment 4 phenotype

(Mollaaghababa et al., 2001)

Scm^D1, ash1²² has adult metathoracic segment phenotype

(Gildea et al., 2000)

Scm^D1/Scm[+], ash1²² has adult metathoracic segment phenotype

(Gildea et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Marcal1^Scer\UAS.cBa under the control of Scer\GAL4^tub.PU is not affected by combination with a single copy of Scm^D1. The homeotic transformation of the mesothoracic legs into prothoracic legs manifesting as extra sex combs characteristic for Scm^D1/+ males is partially suppressed by Marcal1^del heterozygosity but combination with two copies of Marcal1^del is lethal.

(Morimoto et al., 2016)

Sfmbt¹ Scm^D1/Scm^Suz302 double mutant clones in the wing disc have a tumour-like phenotype that is characterized by unrestricted cell proliferation (this phenotype is not seen in single mutant clones). calypso² Scm^D1/Scm^Suz302 double mutant clones in the wing disc do not show a tumour-like phenotype.

(Grimm et al., 2009)

Cuticles of Scm^D1 trx^E2 mutant clone larvae show complete homeotic transformation of all segments into copies of the eight abdominal segment and are indistinguishable from Scm^D1 and esc⁶ mutants.

(Klymenko and Muller, 2004)

Scm^D1 corto⁴²⁰ double heterozygous males derived from corto⁴²⁰/+ females often have ectopic sex combs on the second and third legs.

(Lopez et al., 2001)

64% of Hsc70-4^54.1 Scm^D1 double heterozygotes show transformation of abdominal segment A4 to A5 (extra black pigmentation is seen on the fourth abdominal tergite in males). 6% of Hsc70-4^54.1 Scm^D1 double heterozygotes show transformation of abdominal segment A6 to A7 (males have a reduced sixth abdominal tergite). No extra sex combs are seen in Hsc70-4^54.1 Scm^D1 double heterozygotes.

(Mollaaghababa et al., 2001)

Double heterozygotes with ash1²² show T3 to T2 transformations.

(Gildea et al., 2000)

Has little or no effect on the phenotype of E2f^GMR.PD Dp^GMR.PD BacA\p35^GMR.PH flies.

(Staehling-Hampton et al., 1999)

Dominantly enhances the homeotic phenotypes of Pc³/+ adults. Partially lethal in double heterozygous combination with Sce^D1. ph-p⁴⁰⁹ males that are also heterozygous for Scm^D1 show partial lethality.

(Bornemann et al., 1998)

Weak suppressor of eye pigment phenotype of w^T81.

(Netter et al., 1998)

Hemizygous mxc^M1 males show weak homeotic phenotypes. Strong enhancement of homeotic transformations is seen in mxc^M1/Y in trans with one mutant copy of Scm^D1.

(Saget et al., 1998)

Has no effect on the phenotypes of ct^2s, ct^4s and ct⁶, where the wing margin enhancer is completely blocked.

(Melnikova et al., 1996)

Xenogenetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1^Scer\UAS.cBa under the control of Scer\GAL4^Bx-MS1096 is not affected by combination with a single copy of Scm^D1.

(Morimoto et al., 2016)

Complementation and Rescue Data

Fails to complement

Scm⁴

(Bornemann et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

24158

w^*; P{neoFRT}82B Scm^D1/TM6C, Sb¹ Tb¹

2406

st¹ in¹ kni^ri-1 Scm^D1/TM3, Sb¹

Kyoto

107313

st¹ in¹ kni^ri-1 Scm^D1/TM3, Sb¹

Notes on Origin

Discoverer

Comments

Complements: dmt^S048103.

(Prokopenko et al., 2000)

Ectopic abd-A expression occurs throughout the A-P axis but cellular distribution within each segment is limited. Abd-B shows a graded expression at 9 hours along the A-P axis, more concentrated in the posterior. By 12 hours the expression is more uniform.

(Simon et al., 1992)

Weak derepression of en expression.

(Moazed and O'Farrell, 1992)

Shows no significant dominant suppression of the nos mutant phenotype.

(Pelegri and Lehmann, 1994)

Silencing of Scer\GAL4-BXD genes is dependent on Pc group gene function, in mutant embryos silencing is lost.

(Muller, 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

(Cukier et al., 2008)

Scm^D1

(Morimoto et al., 2016, Bivik et al., 2015, Ji et al., 2012, Grimm et al., 2009, Christensen et al., 2008.4.15, Bello et al., 2007, de Ayala Alonso et al., 2007, Grimm et al., 2007, Huang et al., 2002)

Name Synonyms

Secondary FlyBase IDs

References (57)

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