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General Information
Symbol
Dmel\ScmD1
Species
D. melanogaster
Name
FlyBase ID
FBal0015270
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Frameshift mutation, deleting the SPM domain.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
ScmD1/+ males display a homeotic transformation of the mesothoracic legs into prothoracic legs manifesting as extra sex combs.
Homozygous neuroblast clones in the third larval instar central brain and ventral ganglion are dramatically reduced in size compared to control clones and show a dramatic reduction in mitotic activity.
Cuticles of ScmD1 mutant clone larvae show complete homeotic transformation of all segments into copies of the eight abdominal segment and are indistinguishable from ScmD1 trxE2 double and esc6 single mutants.
Somatic mitotic clones of ScmD1 cause the formation of multicyst egg chambers and giant interfollicular stalks.
13% of heterozygotes show transformation of abdominal segment A4 to A5 (extra black pigmentation is seen on the fourth abdominal tergite in males). 6% of heterozygotes show transformation of abdominal segment A6 to A7 (males have a reduced sixth abdominal tergite). No extra sex combs are seen in heterozygotes.
Transformation of second to first leg.
Homozygotes die during the embryonic or first larval instar stages. Homozygous embryos derived from homozygous female germ line clones have all segments transformed towards the eighth abdominal segment.
Mutation does not affect the level of w expression in ph-plac+3 flies.
In z1 wzm strain mutation causes reduction of eye pigmentation.
Embryonic lethal or semi-lethal when heterozygous with ph-d2. Unhatched larvae carry segmentation defects or polarity defects.
Embryos doubly mutant for PscArp.1 and ScmD1 show strong posteriorly directed segmental transformations. There is severe erosion of the ventral setae in the second and third thoracic segments, any setae present on these segments appear to be primarily or entirely abdominal. Ectopic Fell hairs are seen in more than 75% of cases.
Homeotic transformation of the prothoracic through the seventh abdominal segments to the eighth abdominal state (Breen, Dev Biol 118:442 ).
Transformation of A6 and A7 toward A8.
enhancer of Ubx Cbx
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
ScmD1 has visible | dominant phenotype, enhanceable by psq[+]/psqunspecified
NOT Enhanced by
Statement
Reference
ScmD1 has visible | homeotic phenotype, non-enhanceable by dom14/dom[+]
Suppressed by
Statement
Reference
ScmD1 has homeotic phenotype, suppressible | partially by Marcal1[+]/Marcal1del
Enhancer of
Statement
Reference
ScmD1/Scm[+] is an enhancer of visible | dominant | homeotic phenotype of ash117, trxB11/trx[+]
ScmD1 is an enhancer of visible | dominant | homeotic phenotype of Pc3
ScmD1/Scm[+] is an enhancer of visible | recessive | homeotic phenotype of mxcM1
NOT Enhancer of
Statement
Reference
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference
ScmD1/Scm[+] is a non-suppressor of visible | adult stage phenotype of Marcal1UAS.cBa, Scer\GAL4Tub.PU
ScmD1 is a non-suppressor of visible phenotype of BEAF-32UAS.cYa, Scer\GAL4GMR.PS
Other
Phenotype Manifest In
Enhanced by
Statement
Reference
ScmD1 has sex comb | ectopic phenotype, enhanceable by gpp[+]/gpp1A
ScmD1 has sex comb | ectopic phenotype, enhanceable by gpp[+]/gppX
ScmD1 has sex comb | ectopic phenotype, enhanceable by gpp[+]/gppXXV
ScmD1 has sex comb | ectopic phenotype, enhanceable by gpp[+]/gpp8
ScmD1 has leg phenotype, enhanceable by psq[+]/psqunspecified
ScmD1 has sex comb | ectopic phenotype, enhanceable by psq[+]/psqunspecified
ScmD1 has phenotype, enhanceable by mxcM1
NOT Enhanced by
Statement
Reference
ScmD1 has mesothoracic leg phenotype, non-enhanceable by dom14/dom[+]
Suppressed by
Statement
Reference
ScmD1 has sex comb phenotype, suppressible | partially by Marcal1[+]/Marcal1del
Enhancer of
Statement
Reference
ScmD1/Scm[+] is an enhancer of adult metathoracic segment phenotype of ash117, trxB11/trx[+]
ScmD1 is an enhancer of phenotype of Abd-BFab7-24
ScmD1 is an enhancer of phenotype of Abd-BFab7-33
ScmD1 is an enhancer of phenotype of Abd-BFab7-14
ScmD1 is an enhancer of phenotype of Abd-BFab7-32
ScmD1 is an enhancer of phenotype of Abd-BFab7-P14.1
ScmD1 is an enhancer of phenotype of Abd-BFab7-19
ScmD1 is an enhancer of phenotype of Abd-BFab7-3
ScmD1 is an enhancer of phenotype of Abd-BFab7-P6.1
ScmD1 is an enhancer of phenotype of Abd-BFab7-28
ScmD1 is an enhancer of phenotype of Abd-BFab7-2
ScmD1 is an enhancer of phenotype of Abd-BFab7-P18.1
ScmD1 is an enhancer of phenotype of mxcM1
NOT Enhancer of
Statement
Reference
ScmD1/Scm[+] is a non-enhancer of wing vein | adult stage phenotype of Marcal1UAS.cBa, Scer\GAL4Tub.PU
ScmD1/Scm[+] is a non-enhancer of eye phenotype of Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU
ScmD1/Scm[+] is a non-enhancer of wing vein | ectopic phenotype of Snr1E1
ScmD1 is a non-enhancer of eye phenotype of CycEJP
ScmD1 is a non-enhancer of eye phenotype of BEAF-32UAS.cYa, Scer\GAL4GMR.PS
Suppressor of
Statement
Reference
ScmD1/Scm[+] is a suppressor of eye phenotype of E2f1dsRNA.UAS.cJa, Scer\GAL4GMR.PU
ScmD1/Scm[+] is a suppressor of eye phenotype of Hsap\MECP2UAS.FL, Scer\GAL4GMR.PU
ScmD1/Scm[+] is a suppressor | partially of adult mesothoracic segment | ectopic phenotype of E(z)Trm
ScmD1/Scm[+] is a suppressor | partially of adult metathoracic segment phenotype of E(z)Trm
ScmD1/Scm[+] is a suppressor of adult prothoracic segment phenotype of E(z)Trm
ScmD1 is a suppressor of phenotype of z1
ScmD1 is a suppressor of wing phenotype of ctn2s
ScmD1 is a suppressor of wing phenotype of ctpN2s
NOT Suppressor of
Statement
Reference
ScmD1/Scm[+] is a non-suppressor of wing vein | adult stage phenotype of Marcal1UAS.cBa, Scer\GAL4Tub.PU
ScmD1/Scm[+] is a non-suppressor of eye phenotype of Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU
ScmD1/Scm[+] is a non-suppressor of wing vein | ectopic phenotype of Snr1E1
ScmD1 is a non-suppressor of eye phenotype of CycEJP
ScmD1 is a non-suppressor of eye phenotype of BEAF-32UAS.cYa, Scer\GAL4GMR.PS
ScmD1 is a non-suppressor of phenotype of w4.Ubx.bxd:pbx.ΔBC2
ScmD1 is a non-suppressor of phenotype of w4.Ubx.bxd:pbx.ΔBC3
Other
Statement
Reference
ScmD1, corto[+]/corto420 has sex comb | ectopic phenotype
Additional Comments
Genetic Interactions
Statement
Reference
The formation of ectopic wing veins observed in adult flies expressing Marcal1Scer\UAS.cBa under the control of Scer\GAL4tub.PU is not affected by combination with a single copy of ScmD1. The homeotic transformation of the mesothoracic legs into prothoracic legs manifesting as extra sex combs characteristic for ScmD1/+ males is partially suppressed by Marcal1del heterozygosity but combination with two copies of Marcal1del is lethal.
Sfmbt1 ScmD1/ScmSuz302 double mutant clones in the wing disc have a tumour-like phenotype that is characterized by unrestricted cell proliferation (this phenotype is not seen in single mutant clones). calypso2 ScmD1/ScmSuz302 double mutant clones in the wing disc do not show a tumour-like phenotype.
Cuticles of ScmD1 trxE2 mutant clone larvae show complete homeotic transformation of all segments into copies of the eight abdominal segment and are indistinguishable from ScmD1 and esc6 mutants.
ScmD1 corto420 double heterozygous males derived from corto420/+ females often have ectopic sex combs on the second and third legs.
64% of Hsc70-454.1 ScmD1 double heterozygotes show transformation of abdominal segment A4 to A5 (extra black pigmentation is seen on the fourth abdominal tergite in males). 6% of Hsc70-454.1 ScmD1 double heterozygotes show transformation of abdominal segment A6 to A7 (males have a reduced sixth abdominal tergite). No extra sex combs are seen in Hsc70-454.1 ScmD1 double heterozygotes.
Double heterozygotes with ash122 show T3 to T2 transformations.
Has little or no effect on the phenotype of E2fGMR.PD DpGMR.PD BacA\p35GMR.PH flies.
Dominantly enhances the homeotic phenotypes of Pc3/+ adults. Partially lethal in double heterozygous combination with SceD1. ph-p409 males that are also heterozygous for ScmD1 show partial lethality.
Weak suppressor of eye pigment phenotype of wT81.
Hemizygous mxcM1 males show weak homeotic phenotypes. Strong enhancement of homeotic transformations is seen in mxcM1/Y in trans with one mutant copy of ScmD1.
Has no effect on the phenotypes of ct2s, ct4s and ct6, where the wing margin enhancer is completely blocked.
Xenogenetic Interactions
Statement
Reference
The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1Scer\UAS.cBa under the control of Scer\GAL4Bx-MS1096 is not affected by combination with a single copy of ScmD1.
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (3)
Notes on Origin
Discoverer
Comments
Comments
Ectopic abd-A expression occurs throughout the A-P axis but cellular distribution within each segment is limited. Abd-B shows a graded expression at 9 hours along the A-P axis, more concentrated in the posterior. By 12 hours the expression is more uniform.
Weak derepression of en expression.
Shows no significant dominant suppression of the nos mutant phenotype.
Silencing of Scer\GAL4-BXD genes is dependent on Pc group gene function, in mutant embryos silencing is lost.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (57)