Frameshift mutation, deleting the SPM domain.
ScmD1/+ males display a homeotic transformation of the mesothoracic legs into prothoracic legs manifesting as extra sex combs.
Homozygous neuroblast clones in the third larval instar central brain and ventral ganglion are dramatically reduced in size compared to control clones and show a dramatic reduction in mitotic activity.
Somatic mitotic clones of ScmD1 cause the formation of multicyst egg chambers and giant interfollicular stalks.
13% of heterozygotes show transformation of abdominal segment A4 to A5 (extra black pigmentation is seen on the fourth abdominal tergite in males). 6% of heterozygotes show transformation of abdominal segment A6 to A7 (males have a reduced sixth abdominal tergite). No extra sex combs are seen in heterozygotes.
Transformation of second to first leg.
Homozygotes die during the embryonic or first larval instar stages. Homozygous embryos derived from homozygous female germ line clones have all segments transformed towards the eighth abdominal segment.
Embryonic lethal or semi-lethal when heterozygous with ph-d2. Unhatched larvae carry segmentation defects or polarity defects.
Embryos doubly mutant for PscArp.1 and ScmD1 show strong posteriorly directed segmental transformations. There is severe erosion of the ventral setae in the second and third thoracic segments, any setae present on these segments appear to be primarily or entirely abdominal. Ectopic Fell hairs are seen in more than 75% of cases.
Homeotic transformation of the prothoracic through the seventh abdominal segments to the eighth abdominal state (Breen, Dev Biol 118:442 ).
Transformation of A6 and A7 toward A8.
enhancer of Ubx Cbx
ScmD1 has visible | dominant phenotype, enhanceable by psq[+]/psqunspecified
ScmD1 has homeotic phenotype, suppressible | partially by Marcal1[+]/Marcal1del
ScmD1/Scm[+] is a non-enhancer of visible | adult stage phenotype of Marcal1UAS.cBa, Scer\GAL4Tub.PU
ScmD1/Scm[+] is a non-enhancer of visible | adult stage phenotype of Hsap\SMARCAL1UAS.cBa, Scer\GAL4Bx-MS1096
ScmD1 is a non-enhancer of visible phenotype of BEAF-32UAS.cYa, Scer\GAL4GMR.PS
ScmD1/Scm[+] is a suppressor of visible phenotype of E2f1dsRNA.UAS.cJa, Scer\GAL4GMR.PU
ScmD1/Scm[+] is a suppressor | partially of visible phenotype of E2f1dsRNA.UAS.cJa, Scer\GAL4ptc-559.1
ScmD1/Scm[+] is a suppressor of abnormal eye color phenotype of Hsap\MECP2R294X.UAS, Scer\GAL4GMR.PU
ScmD1 is a suppressor of abnormal eye color phenotype of w4.Ubx.bxd:pbx.ΔBC1
ScmD1 is a suppressor of abnormal eye color phenotype of w4.Ubx.bxd:pbx.ΔBC3-PHO2
ScmD1 is a suppressor of abnormal eye color phenotype of w4.Ubx.bxd:pbx.ΔBC3-PHO1
ScmD1 is a suppressor of abnormal eye color phenotype of w4.Ubx.bxd:pbx.ΔBC3-PHO1-2
ScmD1 is a suppressor of abnormal eye color phenotype of wT81
ScmD1/Scm[+] is a non-suppressor of visible | adult stage phenotype of Marcal1UAS.cBa, Scer\GAL4Tub.PU
ScmD1/Scm[+] is a non-suppressor of visible | adult stage phenotype of Hsap\SMARCAL1UAS.cBa, Scer\GAL4Bx-MS1096
ScmD1 is a non-suppressor of visible phenotype of BEAF-32UAS.cYa, Scer\GAL4GMR.PS
Marcal1del, ScmD1 has lethal phenotype
ScmSuz302/ScmD1, Sfmbt1 has neoplasia | somatic clone phenotype
Hsc70-454.1, ScmD1 has visible | dominant | homeotic phenotype
Hsc70-4[+]/Hsc70-454.1, ScmD1 has visible | dominant | homeotic phenotype
SceD1, ScmD1 has partially lethal | dominant phenotype
ScmD1, ph-p409 has partially lethal phenotype
ScmD1 has leg phenotype, enhanceable by psq[+]/psqunspecified
ScmD1 has sex comb | ectopic phenotype, enhanceable by psq[+]/psqunspecified
ScmD1 has mesothoracic leg phenotype, non-enhanceable by dom14/dom[+]
ScmD1 has sex comb phenotype, suppressible | partially by Marcal1[+]/Marcal1del
ScmD1 has neuroblast | somatic clone phenotype, suppressible by Scer\GAL4αTub84B.PL/BacA\p35UAS.cHa
ScmD1/Scm[+] is an enhancer of adult metathoracic segment phenotype of ash117, trxB11/trx[+]
ScmD1 is an enhancer of phenotype of Abd-BFab7-24
ScmD1 is an enhancer of phenotype of Abd-BFab7-33
ScmD1 is an enhancer of phenotype of Abd-BFab7-14
ScmD1 is an enhancer of phenotype of Abd-BFab7-32
ScmD1 is an enhancer of phenotype of Abd-BFab7-P14.1
ScmD1 is an enhancer of phenotype of Abd-BFab7-19
ScmD1 is an enhancer of phenotype of Abd-BFab7-3
ScmD1 is an enhancer of phenotype of Abd-BFab7-P6.1
ScmD1 is an enhancer of phenotype of Abd-BFab7-28
ScmD1 is an enhancer of phenotype of Abd-BFab7-2
ScmD1 is an enhancer of phenotype of Abd-BFab7-P18.1
ScmD1/Scm[+] is a non-enhancer of wing vein | adult stage phenotype of Marcal1UAS.cBa, Scer\GAL4Tub.PU
ScmD1/Scm[+] is a non-enhancer of wing vein | adult stage phenotype of Hsap\SMARCAL1UAS.cBa, Scer\GAL4Bx-MS1096
ScmD1/Scm[+] is a non-enhancer of eye phenotype of Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU
ScmD1 is a non-enhancer of eye phenotype of BEAF-32UAS.cYa, Scer\GAL4GMR.PS
ScmD1/Scm[+] is a suppressor of eye phenotype of E2f1dsRNA.UAS.cJa, Scer\GAL4GMR.PU
ScmD1/Scm[+] is a suppressor | partially of 1st posterior cell phenotype of E2f1dsRNA.UAS.cJa, Scer\GAL4ptc-559.1
ScmD1/Scm[+] is a suppressor of eye phenotype of Hsap\MECP2UAS.FL, Scer\GAL4GMR.PU
ScmD1/Scm[+] is a suppressor | partially of adult mesothoracic segment | ectopic phenotype of E(z)Trm
ScmD1/Scm[+] is a suppressor | partially of adult metathoracic segment phenotype of E(z)Trm
ScmD1/Scm[+] is a suppressor of adult prothoracic segment phenotype of E(z)Trm
ScmD1 is a suppressor of pigment cell phenotype of w4.Ubx.bxd:pbx.ΔBC1
ScmD1 is a suppressor of pigment cell phenotype of w4.Ubx.bxd:pbx.ΔBC3-PHO2
ScmD1 is a suppressor of pigment cell phenotype of w4.Ubx.bxd:pbx.ΔBC3-PHO1
ScmD1 is a suppressor of pigment cell phenotype of w4.Ubx.bxd:pbx.ΔBC3-PHO1-2
ScmD1/Scm[+] is a non-suppressor of wing vein | adult stage phenotype of Marcal1UAS.cBa, Scer\GAL4Tub.PU
ScmD1/Scm[+] is a non-suppressor of wing vein | adult stage phenotype of Hsap\SMARCAL1UAS.cBa, Scer\GAL4Bx-MS1096
ScmD1/Scm[+] is a non-suppressor of eye phenotype of Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU
ScmD1 is a non-suppressor of eye phenotype of BEAF-32UAS.cYa, Scer\GAL4GMR.PS
ScmD1 is a non-suppressor of phenotype of w4.Ubx.bxd:pbx.ΔBC2
ScmD1 is a non-suppressor of phenotype of w4.Ubx.bxd:pbx.ΔBC3
ScmSuz302/ScmD1, Sfmbt1 has wing disc | somatic clone phenotype
Hsc70-4[+]/Hsc70-454.1, ScmD1 has adult abdominal segment 5 | ectopic phenotype
Hsc70-4[+]/Hsc70-454.1, ScmD1 has adult abdominal segment 6 phenotype
Hsc70-4[+]/Hsc70-454.1, ScmD1 has adult abdominal segment 7 | ectopic phenotype
Hsc70-454.1, ScmD1 has abdominal tergite 4 | male phenotype
Hsc70-454.1, ScmD1 has abdominal tergite 6 | male phenotype
Hsc70-454.1, ScmD1 has adult abdominal segment 4 phenotype
Hsc70-454.1, ScmD1 has adult abdominal segment 5 | ectopic phenotype
Hsc70-454.1, ScmD1 has adult abdominal segment 6 phenotype
Hsc70-454.1, ScmD1 has adult abdominal segment 7 | ectopic phenotype
Hsc70-4[+]/Hsc70-454.1, ScmD1 has abdominal tergite 4 | male phenotype
Hsc70-4[+]/Hsc70-454.1, ScmD1 has abdominal tergite 6 | male phenotype
Hsc70-4[+]/Hsc70-454.1, ScmD1 has adult abdominal segment 4 phenotype
ScmD1, ash122 has adult metathoracic segment phenotype
ScmD1/Scm[+], ash122 has adult metathoracic segment phenotype
The formation of ectopic wing veins observed in adult flies expressing Marcal1Scer\UAS.cBa under the control of Scer\GAL4tub.PU is not affected by combination with a single copy of ScmD1.
The homeotic transformation of the mesothoracic legs into prothoracic legs manifesting as extra sex combs characteristic for ScmD1/+ males is partially suppressed by Marcal1del heterozygosity but combination with two copies of Marcal1del is lethal.
64% of Hsc70-454.1 ScmD1 double heterozygotes show transformation of abdominal segment A4 to A5 (extra black pigmentation is seen on the fourth abdominal tergite in males). 6% of Hsc70-454.1 ScmD1 double heterozygotes show transformation of abdominal segment A6 to A7 (males have a reduced sixth abdominal tergite). No extra sex combs are seen in Hsc70-454.1 ScmD1 double heterozygotes.
Double heterozygotes with ash122 show T3 to T2 transformations.
Has little or no effect on the phenotype of E2fGMR.PD DpGMR.PD BacA\p35GMR.PH flies.
Weak suppressor of eye pigment phenotype of wT81.
The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1Scer\UAS.cBa under the control of Scer\GAL4Bx-MS1096 is not affected by combination with a single copy of ScmD1.
Complements: dmtS048103.
Ectopic abd-A expression occurs throughout the A-P axis but cellular distribution within each segment is limited. Abd-B shows a graded expression at 9 hours along the A-P axis, more concentrated in the posterior. By 12 hours the expression is more uniform.
Weak derepression of en expression.
Shows no significant dominant suppression of the nos mutant phenotype.
Silencing of Scer\GAL4-BXD genes is dependent on Pc group gene function, in mutant embryos silencing is lost.