ScmD1/+ males display a homeotic transformation of the mesothoracic legs into prothoracic legs manifesting as extra sex combs.
Homozygous neuroblast clones in the third larval instar central brain and ventral ganglion are dramatically reduced in size compared to control clones and show a dramatic reduction in mitotic activity.
Cuticles of ScmD1 mutant clone larvae show complete homeotic transformation of all segments into copies of the eight abdominal segment and are indistinguishable from ScmD1 trxE2 double and esc6 single mutants.
Somatic mitotic clones of ScmD1 cause the formation of multicyst egg chambers and giant interfollicular stalks.
13% of heterozygotes show transformation of abdominal segment A4 to A5 (extra black pigmentation is seen on the fourth abdominal tergite in males). 6% of heterozygotes show transformation of abdominal segment A6 to A7 (males have a reduced sixth abdominal tergite). No extra sex combs are seen in heterozygotes.
Transformation of second to first leg.
Homozygotes die during the embryonic or first larval instar stages. Homozygous embryos derived from homozygous female germ line clones have all segments transformed towards the eighth abdominal segment.
Mutation does not affect the level of w expression in ph-plac+3 flies.
In z1 wzm strain mutation causes reduction of eye pigmentation.
Embryonic lethal or semi-lethal when heterozygous with ph-d2. Unhatched larvae carry segmentation defects or polarity defects.
Embryos doubly mutant for PscArp.1 and ScmD1 show strong posteriorly directed segmental transformations. There is severe erosion of the ventral setae in the second and third thoracic segments, any setae present on these segments appear to be primarily or entirely abdominal. Ectopic Fell hairs are seen in more than 75% of cases.
Homeotic transformation of the prothoracic through the seventh abdominal segments to the eighth abdominal state (Breen, Dev Biol 118:442 ).
Transformation of A6 and A7 toward A8.