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General Information
Symbol
Dmel\sd58d
Species
D. melanogaster
Name
FlyBase ID
FBal0015364
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
sd58
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The severity of wing defects caused by expression of sdScer\UAS.cVa under the control of Scer\GAL4vg.int2.1 is suppressed by sd58d/+; in the double mutant flies 61% have a "mild" phenotype (wings are significantly reduced, few veins and crossveins are still distinguishable), 34% have a "severe" phenotype (wing blade growth is severely impaired) and 5% have an "extreme" phenotype (thorax flight appendages are completely missing and no hinge structures are present).

Expression of one of sdΔ200.Scer\UAS, sdΔ124-159.Scer\UAS, sdΔ88-159.Scer\UAS, sdΔ160-219.Scer\UAS and sdΔ88-123.Scer\UAS when driven by Scer\GAL4vg.boundary, lead to an enhancement of the wing phenotype seen in sdETX4 mutants. Expression of either sdΔ87.Scer\UAS or sdScer\UAS.cSa driven by Scer\GAL4vg.boundary can either rescue the sd58d defective wing phenotype, or can actually make this phenotype more severe, depending on the insertion lines used. The effect of these insertions is also temperature sensitive, with certain insertions suppressing the sd58d phenotype at one temperature and enhancing it at another.

Dorsal medial muscles in sd58d mutants display no obvious phenotype.

Mutant wing discs show a lower number of mitotically active cells, as well as a smaller wing pouch. Mutant animals small malformed small wings.

Mutant animals show extensive loss of wing tissue and diminutive halteres.

In developing imaginal discs, sd58d mutant clones can sometimes be recovered even 4 days after clone induction in proximal regions of the wing blade, but not in distal regions.

Strong wing reduction.

Ectopic bristles on the distal wing blade.

Incomplete penetrance of the nibbled wing margin phenotype. Ectopic bristles are never seen on the wing veins.

Wings reduced to vestiges, like vg. Halteres and bristles also like vg. sd58d/sd has strap-shaped wing. Temperature sensitive; effects of temperature pulses at different developmental stages suggest that wing areas eliminated in a specific order (Simpson, Lawrence and Maschat, 1981). RK2A.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Suppressor of
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The defective wing phenotypes seen when sdScer\UAS.cSa or sdΔ200.Scer\UAS are expressed under control of Scer\GAL4vg.boundary in sd58d mutants is alleviated when vgScer\UAS.cKa is overexpressed.

sd58d/+, vgnull/+ females display a wildtype wing phenotype.

In sensScer\UAS.cNa, Scer\GAL4dpp.blk1, sd58d animals no ectopic bristles are seen on the wing.

The addition of sd::vgScer\UAS.sdTEA (driven by Scer\GAL4vg.PM) to sd58d animals, almost completely rescues the wing and haltere phenotype. The wing margin bristles are almost completely restored and the size of the haltere is also restored.

Flies expressing vgScer\UAS.cKa under the control of Scer\GAL4dpp.blk1 show massive outgrowth of wing tissue from the eye. This phenotype is partially suppressed if the flies are heterozygous for sd58d and completely suppressed if the flies are hemizygous for sd58d.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of sdScer\UAS.cSa under the control of Scer\GAL4vg.boundary restores wing development in sd58d mutants.

Expression of sdScer\UAS.T:Zzzz\FLAG,T:Uuuu\MyrPalm2 under the control of Scer\GAL4vg.boundary fails to restore wing development in sd58d mutants.

Expression of sdmNLS.Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4vg.boundary fails to restore wing development in sd58d mutants.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

Ives, 14th April 1958.

Comments
Comments

Cis acting control mutant.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (20)