|Feature type||allele||Associated gene||Dmel\sd|
|Also Known As||sd58|
|Allele class||hypomorphic allele - genetic evidence|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Caused by aberration|
|Phenotype Manifest In|
macrochaeta & wing
The severity of wing defects caused by expression of sdScer\UAS.cVa under the control of Scer\GAL4vg.int2.1 is suppressed by sd58d/+; in the double mutant flies 61% have a "mild" phenotype (wings are significantly reduced, few veins and crossveins are still distinguishable), 34% have a "severe" phenotype (wing blade growth is severely impaired) and 5% have an "extreme" phenotype (thorax flight appendages are completely missing and no hinge structures are present).
Expression of one of sdΔ200.Scer\UAS, sdΔ124-159.Scer\UAS, sdΔ88-159.Scer\UAS, sdΔ160-219.Scer\UAS and sdΔ88-123.Scer\UAS when driven by Scer\GAL4vg.boundary, lead to an enhancement of the wing phenotype seen in sdETX4 mutants. Expression of either sdΔ87.Scer\UAS or sdScer\UAS.cSa driven by Scer\GAL4vg.boundary can either rescue the sd58d defective wing phenotype, or can actually make this phenotype more severe, depending on the insertion lines used. The effect of these insertions is also temperature sensitive, with certain insertions suppressing the sd58d phenotype at one temperature and enhancing it at another.
Mutant wing discs show a lower number of mitotically active cells, as well as a smaller wing pouch. Mutant animals small malformed small wings.
Mutant animals show extensive loss of wing tissue and diminutive halteres.
In developing imaginal discs, sd58d mutant clones can sometimes be recovered even 4 days after clone induction in proximal regions of the wing blade, but not in distal regions.
Strong wing reduction.
Ectopic bristles on the distal wing blade.
Incomplete penetrance of the nibbled wing margin phenotype. Ectopic bristles are never seen on the wing veins.
Wings reduced to vestiges, like vg. Halteres and bristles also like vg. sd58d/sd has strap-shaped wing. Temperature sensitive; effects of temperature pulses at different developmental stages suggest that wing areas eliminated in a specific order (Simpson, Lawrence and Maschat, 1981). RK2A.
|Phenotype Manifest In|
Scer\GAL4vg.boundary, sd58d, sdScer\UAS.cSa has wing phenotype, suppressible by vgScer\UAS.cKa/vgScer\UAS.cKa/Scer\GAL4vg.boundary
Scer\GAL4vg.boundary, sdΔ200.Scer\UAS, sd58d has wing phenotype, suppressible by vgScer\UAS.cKa/vgScer\UAS.cKa/Scer\GAL4vg.boundary
The defective wing phenotypes seen when sdScer\UAS.cSa or sdΔ200.Scer\UAS are expressed under control of Scer\GAL4vg.boundary in sd58d mutants is alleviated when vgScer\UAS.cKa is overexpressed.
The addition of sd::vgScer\UAS.sdTEA (driven by Scer\GAL4vg.PM) to sd58d animals, almost completely rescues the wing and haltere phenotype. The wing margin bristles are almost completely restored and the size of the haltere is also restored.
|Complementation & Rescue Data|
|Not rescued by|
|Stocks ( 1 )|
|Notes on Origin|
Ives, 14th April 1958.
Cis acting control mutant.
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 2 )|
|Secondary FlyBase IDs|
|References ( 19 )|