Allele Dmel\Ser^rev2-11

General Information
Symbol	Dmel\Ser^rev2-11	Species	D. melanogaster
Name		FlyBase ID	FBal0015429
Feature type	allele	Associated gene	Dmel\Ser

Allele class	loss of function allele, amorphic allele - genetic evidence
Mutagen	X ray
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Sun and Artavanis-Tsakonas, 1996) loss of function allele (de Celis et al., 1996)
Mutagen	X ray (Fleming et al., 1990)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	Ser^D (Fleming et al., 1990)
Nature of the lesion	Statement Reference Inversion breakpoint maps within the extracellular domain. (Sun and Artavanis-Tsakonas, 1996)
Caused by aberration	In(3R)Ser^rv2-11 (Fleming et al., 1990, Sun and Artavanis-Tsakonas, 1996)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage (Fleming et al., 1990) visible \| somatic clone (de Celis et al., 1996)
Phenotype Manifest In
	wing \| dorsal compartment \| somatic clone (de Celis et al., 1996)
Detailed Description
	Statement Reference Homozygous clones in the eye disc do not result in obvious defects in the size of the eye disc or photoreceptor differentiation. (Chern and Choi, 2002) Homozygous clones abutting the wing margin in the dorsal wing compartment or induced before dorso-ventral lineage segregation cause extensive wing scalloping. (de Celis et al., 1996) Mosaic eye clones appear wild type. (Sun and Artavanis-Tsakonas, 1996) homozygous lethal
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments	fails to complement Ser^Bd-3
Stocks ( 0 )

Notes on Origin
Discoverer	Fleming.

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	Bd^Srv2 Ser^rev2-11 (Lei et al., 2003) ser^Rev2-11 (Thomas and van Meyel, 2007)
Name Synonym
Secondary FlyBase IDs

References ( 6 )
Research paper	Thomas and van Meyel, 2007, Development 134(3): 591--600 The glycosyltransferase Fringe promotes Delta-Notch signaling between neurons and glia, and is required for subtype-specific glial gene expression. [FBrf0192828] Lei et al., 2003, Development 130(26): 6411--6421 An O-fucose site in the ligand binding domain inhibits Notch activation. [FBrf0167520] Chern and Choi, 2002, Development 129(17): 4005--4013 Lobe mediates Notch signaling to control domain-specific growth in the Drosophila eye disc. [FBrf0151277] de Celis et al., 1996, Development 122(1): 359--369 Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc. [FBrf0086228] Sun and Artavanis-Tsakonas, 1996, Development 122(8): 2465--2474 The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands. [FBrf0089839] Fleming et al., 1990, Genes Dev. 4: 2188--2201 The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster. [FBrf0051848]

Allele Dmel\Serrev2-11

Allele Dmel\Ser^rev2-11