|Feature type||allele||Associated gene||Dmel\Sh|
|Also Known As||W32|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Breakpoint within the Sh coding region, 3' to the exon encoding the "D" 5' alternative end. This prevents transcription of all transcripts containing the "B" and "D" 5' alternative ends.
Translocation breakpoint is at map position +95.2 to +98.7.
break at 95.2 to 98.7; relative to the Sh chromosomal walk in kb (Kamb, Iverson and Tanouye, 1987)
|Caused by aberration|
|Phenotype Manifest In|
The spontaneous miniature excitatory junctional potential (mEJP) frequency is significantly increased in Sh/Sh mutant larvae compared with wild-type controls.
Application of serotonin failed to alter modulation of the potassium channel in a semi-intact preparation of the retina.
Flies show a typical Sh mutant leg shaking phenotype. Hemizygous males show a reduced preference for sucrose compared to wild-type in feeding preference tests, probably due to a shift in the threshold of detection. The response of flies to 100mM NaCl and 0.2M KCl is not significantly different to wild-type. Flies show an increased tolerance to 0.5M NaCl compared to wild-type, due to an increase in the threshold of repulsion.
Photoreceptor A channels have abnormal inactivation kinetics; the rate of inactivation is faster than wild-type.
Shaking phenotype: K+ muscle current is abnormal and the action potential from the CGF interneuron is defective.
abnormal leg shaking under ether anesthesia; abnormal A-type potassium currents in larval muscle and/or pupal flight muscle; abnormal action potentials in the adult cervical giant fiber
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 4 )|
|Secondary FlyBase IDs|
|References ( 13 )|