Allele Dmel\shi³

General Information
Symbol	Dmel\shi³	Species	D. melanogaster
Name		FlyBase ID	FBal0015612
Feature type	allele	Associated gene	Dmel\shi
Also Known As	shi^ts3

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	epidermis (Seugnet et al., 1997) microchaeta (Seugnet et al., 1997)
Detailed Description
	Statement Reference Mutants are shifted to 29^oC at the time of microchaetae precursor determination (14-10 hours APF). Mutants differentiate a large number of extra microchaetes, phenotype is more severe in medial than lateral areas of the thorax. The mutant phenotype results from the development of an excess of neural precursors at the expense of epidermal cells. Clones generated during the first and second larval stages present a strong neurogenic phenotype and bristles along the border can be either wild type or mutant. Occasionally a mutant bristle can be found adjacent to a wild type one. Mutant cells are defective in both sending and receiving the lateral signal. (Seugnet et al., 1997) temperature-sensitive temperature of adult paralysis: 29^oC temperature of larval paralysis: 29^oC temperature causing developmental defects: 29^oC viability of allele over deficiency: very weak
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer	Grigliatti.

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	shi³ shi^ts3 (Phillips et al., 2000, Seugnet et al., 1997, Robertson et al., 2000)
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Phillips et al., 2000, J. Neurosci. 20(22): 8254--8261 The products of the Drosophila stoned locus interact with synaptic vesicles via synaptotagmin. [FBrf0131377] Robertson et al., 2000, Oncogene 19(29): 3299--3308 A Drosophila analogue of v-Cbl is a dominant-negative oncoprotein in vivo. [FBrf0130045] Seugnet et al., 1997, Dev. Biol. 192(2): 585--598 Requirement for dynamin during Notch signaling in Drosophila neurogenesis. [FBrf0100241] Grigliatti et al., 1973, Mol. Gen. Genet. 120: 107--114 Temperature-sensitive mutations in Drosophila melanogaster. [FBrf0025523]

Allele Dmel\shi3

Allele Dmel\shi³