Allele Dmel\sina⁴

General Information
Symbol	Dmel\sina⁴	Species	D. melanogaster
Name		FlyBase ID	FBal0015668
Feature type	allele	Associated gene	Dmel\sina

Map ( GBrowse )
Allele class	loss of function allele, hypomorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (Lindsley and Zimm, 1992) loss of function allele (Kauffmann et al., 1996)
Mutagen	ethyl methanesulfonate (Carthew and Rubin, 1990)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 3L:16,850,067..16,850,067 comment=Nucleotide coordinate of mutation determined from Figure 5B of FBrf0051381 and differs from the position listed in Table 1. evidence=experimental na_change=C16850067T pr_change=H184Y\|sina-PA,H184Y\|sina-PB reported_na_change=C1452T reported_pr_change=H184Y (Carthew and Rubin, 1990)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: H184Y. (Carthew et al., 1994) Amino acid replacement: H184Y. Nucleotide substitution: C1452T. (Carthew and Rubin, 1990)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	photoreceptor cell R7 (Kauffmann et al., 1996)
Detailed Description
	Statement Reference 20% ommatidia have lost the R7 photoreceptor cell. (Kauffmann et al., 1996) 80% of homozygotes are wild type for R7 cell formation, 90% of hemizygotes are missing R7 cells. (Carthew et al., 1994) Weak allele. (Carthew and Rubin, 1990)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Statement Reference sina⁴ is a non-enhancer of visible phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR (Sullivan and Rubin, 2002) sina⁴ is a non-enhancer of visible phenotype of Pp2B-14D^act.GMR (Sullivan and Rubin, 2002)
NOT Suppressor of
Statement Reference sina⁴ is a non-suppressor of visible phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR (Sullivan and Rubin, 2002) sina⁴ is a non-suppressor of visible phenotype of Pp2B-14D^act.GMR (Sullivan and Rubin, 2002)
Phenotype Manifest In
Enhanced by
Statement Reference sina⁴ has phenotype, enhanceable by E(sina)1^D1 (Carthew et al., 1994) sina⁴ has phenotype, enhanceable by E(sina)3^K1 (Carthew et al., 1994) sina⁴ has phenotype, enhanceable by E(sina)4^K5 (Carthew et al., 1994) sina⁴ has phenotype, enhanceable by E(sina)6^L3 (Carthew et al., 1994) sina⁴ has phenotype, enhanceable by E(sina)6^M4 (Carthew et al., 1994) sina⁴ has phenotype, enhanceable by E(sina)46C^M1 (Carthew et al., 1994) sina⁴ has phenotype, enhanceable by ES1-1^e341 (Neufeld et al., 1998) sina⁴ has phenotype, enhanceable by fry^s308 (Neufeld et al., 1998) sina⁴ has phenotype, enhanceable by gl^ES5 (Carthew et al., 1994) sina⁴ has phenotype, enhanceable by Hsp83^H3 (Carthew et al., 1994) sina⁴ has phenotype, enhanceable by pnut^H2 (Carthew et al., 1994) sina⁴ has phenotype, enhanceable by pros¹⁰⁴¹⁹ (Kauffmann et al., 1996) sina⁴ has phenotype, enhanceable by pros^JO1 (Kauffmann et al., 1996) sina⁴ has phenotype, enhanceable by rl^ES7 (Carthew et al., 1994) sina⁴ has phenotype, enhanceable by S^e220 (Neufeld et al., 1998) sina⁴ has phenotype, enhanceable by Sin3A^e64 (Neufeld et al., 1998) sina⁴ has phenotype, enhanceable by SS3-6^s297 (Neufeld et al., 1998) sina⁴ has photoreceptor cell R7 phenotype, enhanceable by pnut¹ (Neufeld and Rubin, 1994)
Suppressed by
Statement Reference sina⁴ has phenotype, suppressible by ES3-1^e139 (Neufeld et al., 1998)
NOT Enhancer of
Statement Reference sina⁴ is a non-enhancer of eye phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR (Sullivan and Rubin, 2002) sina⁴ is a non-enhancer of eye phenotype of Pp2B-14D^act.GMR (Sullivan and Rubin, 2002)
NOT Suppressor of
Statement Reference sina⁴ is a non-suppressor of eye phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR (Sullivan and Rubin, 2002) sina⁴ is a non-suppressor of eye phenotype of Pp2B-14D^act.GMR (Sullivan and Rubin, 2002)
Other
Statement Reference E(sina)4^K5, sina⁴ has secondary pigment cell phenotype (Carthew et al., 1994) E(sina)6^M4/E(sina)6^L3, sina⁴ has posterior crossvein phenotype (Carthew et al., 1994, Carthew et al., 1994) E(sina)6^M4/E(sina)6^L3, sina⁴ has wing vein \| ectopic phenotype (Carthew et al., 1994, Carthew et al., 1994) Hsp83^H3, sina⁴ has secondary pigment cell phenotype (Carthew et al., 1994)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Weak sina mutation. (Kauffmann et al., 1996) No interaction with P{sev-svp1} or P{sev-svp2} exists. (Begemann et al., 1995) Weak allele. Immunohistochemistry demonstrates that the mutation does not affect gene product abundance or localisation. (Carthew et al., 1994)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	sina⁴
Name Synonym
Secondary FlyBase IDs

References ( 8 )
Research paper	Sullivan and Rubin, 2002, Genetics 161(1): 183--193 The Ca(2+)-calmodulin-activated protein phosphatase calcineurin negatively regulates EGF receptor signaling in Drosophila development. [FBrf0149012] Neufeld et al., 1998, Genetics 148(1): 277--286 A genetic screen to identify components of the sina signaling pathway in Drosophila eye development. [FBrf0100609] Kauffmann et al., 1996, Genes Dev. 10(17): 2167--2178 Ras1 signaling and transcriptional competence in the R7 cell of Drosophila. [FBrf0089979] Begemann et al., 1995, Development 121(1): 225--235 The Drosophila orphan nuclear receptor Seven-up requires the Ras pathway for its function in photoreceptor determination. [FBrf0076133] Carthew et al., 1994, Proc. Natl. Acad. Sci. U.S.A. 91(24): 11689--11693 Identification of genes that interact with the sina gene in Drosophila eye development. [FBrf0077257] Neufeld and Rubin, 1994, Cell 77(3): 371--379 The Drosophila peanut gene is required for cytokinesis and encodes a protein similar to yeast putative bud neck filament proteins. [FBrf0074019] Carthew and Rubin, 1990, Cell 63: 561--577 seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye. [FBrf0051381]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]

Allele Dmel\sina4

Allele Dmel\sina⁴