FlyBase Allele Report: Dmel\skd[2]

General Information

Symbol

Dmel\skd²

Species

D. melanogaster

Name

FlyBase ID

FBal0015676

Feature type

allele

Associated gene

Dmel\skd

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

gamma ray

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Gindhart and Kaufman, 1995)

Mutagen

gamma ray

(Kennison and Tamkun, 1988)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Kennison and Tamkun, 1988)

Phenotype Manifest In

larval somatic muscle cell

(Dobi et al., 2014)

scutellar bristle | ectopic

(Mariappa et al., 2018)

Detailed Description

Statement

Reference

A small proportion of skd² heterozygous adults show an ectopic scutellar bristle phenotype, as compared to controls.

(Mariappa et al., 2018)

brm² shows little if any interaction in double heterozygous combination with skd²; less than 3% of flies have held-out wings.

(Vazquez et al., 1999)

Mutation does not affect the level of w expression in ph-p^lac+3 flies.

(Fauvarque et al., 1995)

Associated with recessive lethality at the larval-pupal transition.

(Lindsley and Zimm, 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

skd² is an enhancer of visible | dominant phenotype of tna¹

(Gutierrez et al., 2003)

NOT Enhancer of

Statement

Reference

skd² is a non-enhancer of visible phenotype of Scer\GAL4^ey.PH, brm^{K804R.UAS.Tag:HA}

(Armstrong et al., 2005)

Suppressor of

Statement

Reference

skd² is a suppressor of lethal phenotype of Ras85D^V12.sev, sev^S11.Tag:MYC

(Maixner et al., 1998)

NOT Suppressor of

Statement

Reference

skd² is a non-suppressor of visible phenotype of Scer\GAL4^ey.PH, brm^{K804R.UAS.Tag:HA}

(Armstrong et al., 2005)

Other

Statement

Reference

Ras85D^V12.sev, sev^S11.Tag:MYC, skd² has viable phenotype

(Maixner et al., 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

skd² has scutellar bristle | ectopic phenotype, enhanceable by sxc[+]/sxc^H537A

(Mariappa et al., 2018)

Enhancer of

Statement

Reference

skd² is an enhancer of wing phenotype of tna¹

(Gutierrez et al., 2003)

NOT Enhancer of

Statement

Reference

skd² is a non-enhancer of eye phenotype of Scer\GAL4^ey.PH, brm^{K804R.UAS.Tag:HA}

(Armstrong et al., 2005)

Suppressor of

Statement

Reference

skd² is a suppressor of eye phenotype of CycE^JP

(Brumby et al., 2002)

skd²/skd[+] is a suppressor of adult mesothoracic segment | ectopic phenotype of E(z)^Trm

(Bajusz et al., 2001)

skd²/skd[+] is a suppressor of adult metathoracic segment phenotype of E(z)^Trm

(Bajusz et al., 2001)

skd²/skd[+] is a suppressor of adult prothoracic segment phenotype of E(z)^Trm

(Bajusz et al., 2001)

skd² is a suppressor of phenotype of Pcl^unspecified

(Lindsley and Zimm, 1992)

skd² is a suppressor of phenotype of Scr^unspecified

(Lindsley and Zimm, 1992)

skd² is a suppressor of phenotype of Ubx^unspecified

(Lindsley and Zimm, 1992)

skd² is a suppressor of phenotype of Antp^Ns

(Lindsley and Zimm, 1992)

skd²/skd[+] is a suppressor of phenotype of Pc^unspecified

(Lindsley and Zimm, 1992)

skd² is a suppressor of phenotype of Pc⁴

(Kennison and Tamkun, 1988)

NOT Suppressor of

Statement

Reference

skd² is a non-suppressor of eye phenotype of Scer\GAL4^ey.PH, brm^{K804R.UAS.Tag:HA}

(Armstrong et al., 2005)

Other

Statement

Reference

Kr^If-1, skd²/skd[+] has eye phenotype

(Sollars et al., 2003)

Kr^If-1, skd² has eye phenotype

(Sollars et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The ectopic scutellar bristle phenotype observed in skd² heterozygotes is enhanced by sxc^H537A heterozygosity, but is not further enhanced by sxc^H537A homozygosity.

(Mariappa et al., 2018)

2+/-1% of Kr^If-1/+ flies born to skd²/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of Kr^If-1/+ flies born to isogenised wild-type mothers.

(Sollars et al., 2003)

Mutant suppresses the CycE^JP eye rough phenotype.

(Brumby et al., 2002)

The lethality caused by sev^{S11.T:Hsap\MYC} in combination with Ras85D^V12.sev is suppressed by skd².

(Maixner et al., 1998)

Isolated as a dominant suppressor of Pc mutations. Also interacts with Pcl, Scr and Ubx mutations. May weakly suppress Antp^Ns.

(Lindsley and Zimm, 1992)

Suppresses the extra sex comb phenotype of Pc⁴, Ts(YLt;2Lt)L124. Causes between 50% and 100% suppression of the Pc⁴/+ extra sex combs phenotype.

(Kennison and Tamkun, 1988)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

skd¹⁸⁵⁵

(de Ayala Alonso et al., 2007)

skd¹⁰⁵²

(de Ayala Alonso et al., 2007)

skd^32A24

(de Ayala Alonso et al., 2007)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

5047

skd²/TM6C, cu¹ Sb¹ ca¹

Kyoto

108007

skd²/TM6C, cu¹ Sb¹ ca¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

skd⁰²

(Vasanthi et al., 2013)

skd²

(Ren et al., 2022, Mariappa et al., 2018, Dobi et al., 2014, Bhatia et al., 2010, Swaminathan et al., 2010, Christensen et al., 2008.4.15, Christensen et al., 2008.7.11, Chang et al., 2007, de Ayala Alonso et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (26)

Report Sections

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