FB2025_01 , released February 20, 2025
Allele: Dmel\sl3
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General Information
Symbol
Dmel\sl3
Species
D. melanogaster
Name
FlyBase ID
FBal0015679
Feature type
allele
Associated gene
Dmel\sl
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
X ray
Progenitor genotype
Caused by aberration
Tp(1;2)r+75c
Cytology
Description

Breakpoint of Tp(1;2)r+75c maps to the SH2-PH domain region of the sl transcription unit.

(Thackeray et al., 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes show a modest reduction in wing length and a mildly rough eye. In addition, homozygotes show ectopic wing veins, most frequently adjacent to L2 but sometimes connected or adjacent to the posterior crossvein or in the posterior cell. Ommatidial array is disrupted, many ommatidia are abnormally shaped. Eyes show interommatidial bristle defects. Some are missing, some are duplicated and some appear at additional vertices. 51% of ommatidia contain extra inner photoreceptors. A small fraction of ommatidia have one or more extra (2%) or missing (10%) outer photoreceptors. The majority of supernumerary photoreceptors show an R7 identity.

      (Thackeray et al., 1998)

      Mutant eye and wing phenotype.

      (Schalet, 1986)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      sl3 is a suppressor of visible phenotype of CanBGMR.PS, Pp2B-14Dact.GMR

      (Sullivan and Rubin, 2002)

      sl3 is a suppressor of visible phenotype of Pp2B-14Dact.GMR

      (Sullivan and Rubin, 2002)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      sl3 is a suppressor of eye phenotype of CanBGMR.PS, Pp2B-14Dact.GMR

      (Sullivan and Rubin, 2002)

      sl3 is a suppressor of eye phenotype of Pp2B-14Dact.GMR

      (Sullivan and Rubin, 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      sl2

      (Thackeray et al., 1998)

      sl1

      (Thackeray et al., 1998)
      Comments

      Complementation data based on rough eye and wing phenotypes.

      (Thackeray et al., 1998)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Lefevre.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      sl3
      Name Synonyms
      Secondary FlyBase IDs
        References (5)