Allele Dmel\sl³

General Information
Symbol	Dmel\sl³	Species	D. melanogaster
Name		FlyBase ID	FBal0015679
Feature type	allele	Associated gene	Dmel\sl

Allele class
Mutagen	X ray
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	X ray
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Breakpoint of Tp(1;2)r⁺75c maps to the SH2-PH domain region of the sl transcription unit. (Thackeray et al., 1998)
Caused by aberration	Tp(1;2)r⁺75c (Thackeray et al., 1998, Schalet, 1986)
Cytology
Phenotypic Data
Phenotypic Class
	viable (Thackeray et al., 1998) visible \| recessive (Thackeray et al., 1998, Schalet, 1986)
Phenotype Manifest In
	eye (Thackeray et al., 1998, Schalet, 1986) eye photoreceptor cell (Thackeray et al., 1998) interommatidial bristle (Thackeray et al., 1998) interommatidial bristle \| ectopic (Thackeray et al., 1998) ommatidium (Thackeray et al., 1998) wing (Thackeray et al., 1998, Schalet, 1986) wing vein \| ectopic (Thackeray et al., 1998)
Detailed Description
	Statement Reference Homozygotes show a modest reduction in wing length and a mildly rough eye. In addition, homozygotes show ectopic wing veins, most frequently adjacent to L2 but sometimes connected or adjacent to the posterior crossvein or in the posterior cell. Ommatidial array is disrupted, many ommatidia are abnormally shaped. Eyes show interommatidial bristle defects. Some are missing, some are duplicated and some appear at additional vertices. 51% of ommatidia contain extra inner photoreceptors. A small fraction of ommatidia have one or more extra (2%) or missing (10%) outer photoreceptors. The majority of supernumerary photoreceptors show an R7 identity. (Thackeray et al., 1998) Mutant eye and wing phenotype. (Schalet, 1986)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference sl³ is a suppressor of visible phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR (Sullivan and Rubin, 2002) sl³ is a suppressor of visible phenotype of Pp2B-14D^act.GMR (Sullivan and Rubin, 2002)
Phenotype Manifest In
Suppressor of
Statement Reference sl³ is a suppressor of eye phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR (Sullivan and Rubin, 2002) sl³ is a suppressor of eye phenotype of Pp2B-14D^act.GMR (Sullivan and Rubin, 2002)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	sl¹ (Thackeray et al., 1998) sl² (Thackeray et al., 1998)
Comments	Complementation data based on rough eye and wing phenotypes. (Thackeray et al., 1998)
Stocks ( 2 )
Bloomington	3217 Tp(1;2)r⁺75c, sl³/CyO; C(1)M4, y²
Kyoto	106924 Tp(1;2)r⁺75c, sl³/CyO; C(1)M4, y²
Notes on Origin
Discoverer	Lefevre.

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	sl³
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Gallio et al., 2004, Development 131(15): 3605--3614 Rhomboid 3 orchestrates Slit-independent repulsion of tracheal branches at the CNS midline. [FBrf0179216] Sullivan and Rubin, 2002, Genetics 161(1): 183--193 The Ca(2+)-calmodulin-activated protein phosphatase calcineurin negatively regulates EGF receptor signaling in Drosophila development. [FBrf0149012] Thackeray et al., 1998, Development 125(24): 5033--5042 small wing encodes a phospholipase C-() that acts as a negative regulator of R7 development in Drosophila. [FBrf0105946] Schalet, 1986, Mutat. Res. 163: 115--144 The distribution of and complementation relationships between spontaneous X-linked recessive lethal mutations recovered from crossing long-term laboratory stocks of Drosophila melanogaster. [FBrf0045066]
Abstract	Thackeray et al., 2000, A. Dros. Res. Conf. 41: 687B Isolation and characterization of new PLC-<font face=symbol>g</font> mutations. [FBrf0126293]

Allele Dmel\sl3

Allele Dmel\sl³