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General Information
Symbol
Dmel\soD
Species
D. melanogaster
Name
FlyBase ID
FBal0015926
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:
T7425201A
Reported nucleotide change:
T?A
Amino acid change:
V200D | so-PA
Reported amino acid change:
V200D
Comment:
V200D amino acid change thought to be responsible for mutant phenotype. soD also contains an amino acid replacement G66A that is not reponsible for the phenotype.
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Amino acid replacement: V200D. Amino acid replacement: G66A. Amino acid residue 200 is within the highly conserved Six domain, while amino acid 66 is in a non-conserved region.
Amino acid replacement: V200D.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
soD/+ animals completely lack compound eyes.
soD/+ mutants are eyeless or have severely reduced eyes. The more copies of the allele present in the fly, the more severe the eye phenotype is. The eye primordia of soD mutants displays normal specification and maintenance, but eye discs become arrested at the time of neuronal morphogenesis and relatively late stages of eye development are affected.
Heterozygotes lack compound eyes and the region normally occupied by the eye is replaced by a large nonpigmented and nondifferentiated field of tissue. Heterozygotes show a complete lack of photoreceptor differentiation during larval eye disc development.
Heterozygotes exhibit an extreme eyeless phenotype, this can be rescued by heat induced expression of so (repetitive heat shocks during third instar).
Heterozygotes display an extreme reduction in eye size.
RK1 Heterozygote has small, glazed eyes.
Heterozygote has very small glazed eyes; more extreme than DrMio/+; soD/+/+ has a very clear phenotype, but weaker than that of DrMio/+ (i.e., about the size of wgGla-1/+, but not glazed). Heterozygote has excellent viability. homozygous lethal. gain-of-function allele
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
soD has visible | dominant phenotype, enhanceable by nej[+]/nej3
Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference
Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference
soD has eye disc phenotype, enhanceable by nej[+]/nej3
soD has eye phenotype, enhanceable by nej[+]/nej3
Suppressed by
NOT suppressed by
Statement
Reference
soD has eye phenotype, non-suppressible by OptixFL.UAS/Scer\GAL4ey.PU
soD has eye phenotype, non-suppressible by so::OptixSD.UAS/Scer\GAL4ey.PU
soD has eye phenotype, non-suppressible by so::OptixCT.UAS/Scer\GAL4ey.PU
soD has eye phenotype, non-suppressible by so::OptixNT+CT.UAS/Scer\GAL4ey.PU
soD has eye phenotype, non-suppressible by so::OptixSD+HD.UAS/Scer\GAL4ey.PU
soD has eye phenotype, non-suppressible by nejΔNZK.UAS/Scer\GAL4unspecified
soD has eye phenotype, non-suppressible by nejΔQ.UAS/Scer\GAL4unspecified
Additional Comments
Genetic Interactions
Statement
Reference
nej3/+ ; soD/+ adults lack eyes and the nondifferentiated field of tissue that is seen in place of the eye in soD/+ single mutants is replaced by head tissue in the double mutant adults. nej3/+ ; soD/+ eye imaginal discs are small and undergo increased levels of cell death. Expression of nejScer\UAS.T:SV5\V5 under the control of Scer\GAL4ey.PH suppresses the no-eye phenotype of soD/+; eye imaginal discs are nearly normal in size and contain large numbers of photoreceptor cell clusters, and in adults, the eyes are fully pigmented, although they are not normally patterned. Expression of nejΔBHQ.Scer\UAS under the control of Scer\GAL4ey.PH suppresses the no-eye phenotype of soD/+, to the same degree as expression of nejScer\UAS.T:SV5\V5 under the control of Scer\GAL4ey.PH. Expression of nejΔNZK.Scer\UAS or nejΔQ.Scer\UAS under the control of Scer\GAL4unspecified does not suppress the no-eye phenotype of soD/+.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
soD is partially rescued by soG66A.hs
Comments
Scer\GAL4ey.PU-mediated expression of soFL.Scer\UAS or soΔNT.Scer\UAS partially restores soD eyes. Scer\GAL4ey.PU-mediated expression of soΔSD.Scer\UAS, soΔHD.Scer\UAS, soΔCT.Scer\UAS or soΔNT+CT.Scer\UAS does not rescue the soD eye phenotype.
soG66A.hs partially rescues the eye phenotype of soD flies in a dosage-dependent manner.
Images (2)
Stocks (2)
Notes on Origin
Discoverer
Sakonju, 1982.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
References (14)