Allele Dmel\Sod^S

General Information
Symbol	Dmel\Sod^S	Species	D. melanogaster
Name	Slow	FlyBase ID	FBal0015932
Feature type	allele	Associated gene	Dmel\Sod
Also Known As	S

Allele class
Mutagen	natural population
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	natural population (Phillips et al., 1995)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name S72589 AAD14963

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Nucleotide replacement: Sod^S differs from Sod^F haplotype A at a single site, having an A instead of a C at site 1013. (Hudson et al., 1994) Asn96 -> Lys96 (Lee and Ayala, 1985)
Carried on aberration	TM3-ISPSAS (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
Cytology
Phenotypic Data
Phenotypic Class
	electrophoretic variant (Phillips et al., 1995)
Phenotype Manifest In

Detailed Description
	Statement Reference Relative frequencies of S and F vary greatly among natural populations. Slow forms of SOD have specific activity 2-3 times that of fast forms and they are more thermolabile (Lee, Misra and Ayala, 1981)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 2 )
Bloomington	4018 Idh^F Sod^F Pgm^6tr Ald²/TM3, Idh^S Sod^S Pgm^4tr Sb¹ Ald⁴ Ser¹
Kyoto	107557 Idh^F Sod^F Pgm^6tr Ald²/TM3, Idh^S Sod^S Pgm^4tr Sb¹ Ald⁴ Ser¹
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	S (Nusbaum and Rose, 1994, Peng et al., 1991) Sod1^s (Kirby et al., 2008) Sod^S Sod-Slow (Sezgin et al., 2004)
Name Synonym	Slow (Hudson et al., 1994)
Secondary FlyBase IDs

References ( 15 )
Research paper	Kirby et al., 2008, J. Biol. Chem. 283(51): 35393--35401 Instability of superoxide dismutase 1 of Drosophila in mutants deficient for its cognate copper chaperone. [FBrf0207119] Sezgin et al., 2004, Genetics 168(2): 923--931 Single-locus latitudinal clines and their relationship to temperate adaptation in metabolic genes and derived alleles in Drosophila melanogaster. [FBrf0180305] Saez et al., 2003, Proc. Natl. Acad. Sci. U.S.A. 100(4): 1793--1798 Patterns of DNA sequence polymorphism at Sod vicinities in Drosophila melanogaster. Unraveling the footprint of a recent selective sweep. [FBrf0157183] Ayala et al., 2002, Gene 300(1-2): 19--29 Genetic polymorphism at two linked loci, Sod and Est-6, in Drosophila melanogaster. [FBrf0155782] Deckert-Cruz et al., 1997, Evolution 51(3): 865--872 Allozymic differentiation in response to laboratory demographic selection of Drosophila melanogaster. [FBrf0094566] Phillips et al., 1995, Proc. Natl. Acad. Sci. U.S.A. 92(19): 8574--8578 Subunit-destabilizing mutations in Drosophila copper zinc superoxide dismutase: Neuropathology and a model of dimer dysequilibrium. [FBrf0084265] Hudson et al., 1994, Genetics 136(4): 1329--1340 Evidence for positive selection in the superoxide dismutase (Sod) region of Drosophila melanogaster. [FBrf0073396] Tyler et al., 1993, Genetica 91(1-3): 143--149 The effect of superoxide dismutase alleles on aging in Drosophila. [FBrf0068721] Milosevic et al., 1991, Genet. Res. (Camb.) 57: 267--272 Fertility and viability at the Sod locus in Drosophila melanogaster: non-additive and asymmetric selection. [FBrf0054091] Peng et al., 1991, Genetics 128: 381--391 Two modes of balancing selection in Drosophila melanogaster: overcompensation and overdominance. [FBrf0054150] Campbell et al., 1986, Genetics 112(2): 205--215 Cytogenetic analysis of the cSOD microregion in Drosophila melanogaster. [FBrf0044430] Schott et al., 1986, Biochem. Genet. 24: 509--527 Molybdenum hydroxylases in Drosophila. [FBrf0043787]
Review	Nusbaum and Rose, 1994, Comp. Biochem. Physiol. A. Physiol. 109(1): 33--38 Aging in Drosophila. [FBrf0075055]
Personal communication to FlyBase	Bloomington Drosophila Stock Center, 2001.8.28, Balancer Variants. Balancer Variants. [FBrf0138610]
FlyBase analysis	FlyBase Curators, 2006-, Balancer summary information. Balancer summary information. [FBrf0189689]

Allele Dmel\SodS

Allele Dmel\Sod^S