FlyBase Allele Report: Dmel\Sod1[n1]

The supplementation of algal cells (from Haematococcus pluvialis) at high concentrations (10 and 20mg/mL) significantly extends the life span of Sodⁿ¹ mutant flies (while this concentration appears to be toxic to control flies). Low concentrations of algal cells do not have a significant effect on the life span of Sodⁿ¹ mutant flies.

The age-dependent decline in locomotor function in Sodⁿ¹ mutant flies is effectively rescued by the intake of Haematococcus pluvialis cells.

(Huangfu et al., 2013)

The lifespan of homozygous Sodⁿ¹ mutants is shorter than than of controls.

(Sun et al., 2012)

Chronic hypoxia (5% O[[2]]) partially restores the abbreviated life span of mutant flies.

(Wicks et al., 2009)

Homozygous flies show a reduction in adult lifespan compared to controls and are extremely hypersensitive to paraquat.

(Kirby et al., 2008)

Homozygotes have a significantly shorter mean and maximum life span than normal; mean life span of the mutants is 12 days (compared to 40 days for controls) and maximum lifespan of the mutants is 24 days (compared to 70 days for controls).

(Rogina and Helfand, 2000)

Homozygous male escapers are sterile and female escapers have reduced fertility. Escapers have reduced longevity and are sensitive to paraquat, buthionine sulfoximine, ionising radiation and hyperoxia compared to control flies.

(Parkes et al., 1998)

In Sodⁿ¹ eggs of L.boulardi are melanotically encapsulated but, in contrast to the wild-type, survive.

(Nappi et al., 1995)

Homozygous adult eye has extensive necrotic lesions throughout the retina. Histological defects also extend into the adjacent lamina of the brain. This neuropathology is consistent with behavioural defects, including motor activity.

(Phillips et al., 1995)

Homozygous larvae are poorly viable at 31^oC.

(Lakhotia, 1994)

Homozygotes that are also homozygous for ry³⁰¹ or ry⁵⁰⁶ die during late metamorphosis and during the process of eclosion.

(Hilliker et al., 1992)

Semilethal.

(Staveley et al., 1991)

Homozygotes life span is 80% less than wild type.

(Staveley et al., 1990)

Originally recovered as a lethal mutation; homozygotes die in the process of eclosion; rare eclosing adults are completely sterile, are devoid of SOD activity and die within 2-3 days; however, some derived sublines show higher adult survival. Surviving homozygous males are sterile and homozygous females produce few if any offspring. Reduced life span and fertility attributed to reduced capacity of embryos, larvae, and pupae to protect developing preimaginal cells from O₂^--initiated cytotoxic damage. Homozygotes hypersensitive to the O₂^--radical-generating compound, paraquat (1,1'-dimethyl-4,4'-bipyridinium dichloride) and copper ions.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Sod1ⁿ¹/Sod1ⁿ⁶⁴ has short lived phenotype, enhanceable by Wwox¹/Wwox¹

(O'Keefe et al., 2011)

Enhancer of

Statement

Reference

Sod1ⁿ¹/Sod[+] is an enhancer of increased cell death | progressive phenotype of Hsap\GFAP^UAS.cWa, Scer\GAL4^repo

(Wang et al., 2011)

Sod1ⁿ¹/Sod[+] is an enhancer of paralytic phenotype of Hsap\GFAP^UAS.cWa, Scer\GAL4^repo

(Wang et al., 2011)

Sod1ⁿ¹/Sod[+] is an enhancer of lethal | recessive phenotype of Trxr-1^G0481

(Missirlis et al., 2001)

Suppressor of

Statement

Reference

Sod1ⁿ¹/Sod[+] is a suppressor of short lived phenotype of Hsap\APP^{Arctic.UAS.Tag:SS(nec)}, Scer\GAL4^elav-C155

(Rival et al., 2009)

Other

Statement

Reference

Sod1ⁿ¹/Sod1ⁿ⁶⁴, Wwox¹/Wwox^f04545 has partially lethal - majority die phenotype

(O'Keefe et al., 2011)

Sod1ⁿ¹/Sod1ⁿ⁶⁴, Wwox¹ has partially lethal - majority die phenotype

(O'Keefe et al., 2011)

Sod1ⁿ¹, whd¹ has lethal | dominant phenotype

(Strub et al., 2008)

Sod1ⁿ¹, qvr¹ has lethal | recessive | pupal stage phenotype

(Humphreys et al., 1996)

Sod1ⁿ¹, qvr¹ has lethal | dominant | pupal stage phenotype

(Humphreys et al., 1996)

Sh⁵, Sod1ⁿ¹ has viable phenotype

(Humphreys et al., 1996)

Hk¹, Sod1ⁿ¹ has viable phenotype

(Humphreys et al., 1996)

Sod1ⁿ¹, eag¹ has viable phenotype

(Humphreys et al., 1996)

Phenotype Manifest In

Enhancer of

Statement

Reference

Sod1ⁿ¹/Sod[+] is an enhancer of lamina phenotype of Hsap\GFAP^UAS.cWa, Scer\GAL4^repo

(Wang et al., 2011)

Sod1ⁿ¹/Sod[+] is an enhancer of adult brain phenotype of Hsap\GFAP^UAS.cWa, Scer\GAL4^repo

(Wang et al., 2011)

Sod1ⁿ¹/Sod[+] is an enhancer of neuron | cell non-autonomous phenotype of Hsap\GFAP^UAS.cWa, Scer\GAL4^repo

(Wang et al., 2011)

NOT Enhancer of

Statement

Reference

Sod1ⁿ¹/Sod[+] is a non-enhancer of eye phenotype of cathD¹

(Kuronen et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Sodⁿ¹/Sodⁿ⁶⁴ Wwox¹/Wwox¹ double mutant adult escapers show further reduction of the shortened lifespan seen in Sodⁿ¹/Sodⁿ⁶⁴ single mutant adults.

(O'Keefe et al., 2011)

qvr¹/+ ; Sodⁿ¹/Sodⁿ¹ and qvr¹/qvr¹ ; Sodⁿ¹/Sodⁿ¹ animals die as late pupae. Sh⁵, Hk¹ and eag¹ double mutants with Sodⁿ¹ are viable.

(Humphreys et al., 1996)

Xenogenetic Interactions

Statement

Reference

A Sodⁿ¹ heterozygous background significantly enhances Hsap\GFAP^Scer\UAS.cWa toxicity and increases the frequency of mechanically-stimulated seizures in these flies. Protection from cellular toxicity does not alter the number of inclusion bodies. An increase in cellular toxicity does not alter the number of inclusion bodies but does increase autophagy induction.

A Sodⁿ¹ heterozygous background significantly enhances Hsap\GFAP^{R79H.Scer\UAS} toxicity and increases the frequency of mechanically-stimulated seizures in these flies. Protection from cellular toxicity does not alter the number of inclusion bodies. An increase in cellular toxicity does not alter the number of inclusion bodies but does increase autophagy induction.

(Wang et al., 2011)

Sodⁿ¹ dominantly suppresses the decreased survival phenotype of flies expressing Hsap\APP^{Arctic.Scer\UAS.T:nec} under the control of Scer\GAL4^elav-C155.

(Rival et al., 2009)

Expression of P{bSOD} restores male fertility and resistance to paraquat to apparently normal levels. Adult life is restored to only 30% of normal and resistance to hyperoxia is 90% of that found in control flies.

(Reveillaud et al., 1994)

Complementation and Rescue Data

Rescued by

Sod1ⁿ¹ is rescued by Sod1^F.tSa

(Parkes et al., 1998)

Comments

Sod^F.tSa rescues the lethality of Sodⁿ¹ homozygotes. The rescued flies are fertile and longevity is essentially wild-type. The rescued flies have a wild-type level of resistance to paraquat and an increased resistance to hyperoxia compared to control flies. Sensitivity to ionising radiation is partially rescued. Sensitivity to buthionine sulfoximine is rescued.

(Parkes et al., 1998)

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

107555

Sod1ⁿ¹ red¹/TM3, Sb¹ Ser¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (19)

Reported As

Symbol Synonym

SOD1ⁿ¹⁰⁸

(Rival et al., 2009)

SODⁿ¹⁰⁸

(Huangfu et al., 2013, Wheeler et al., 1995)

SODⁿ¹

(Liu et al., 2015)

Sod-1ⁿ¹

(Staatz et al., 2005)

Sod1^G51S

(Cacciottolo et al., 2019)

Sod1ⁿ¹⁰⁸

(Cacciottolo et al., 2019, Blackney et al., 2014, Wicks et al., 2009, Kirby et al., 2008, Missirlis et al., 2003)

Sod1ⁿ¹

(Cacciottolo et al., 2019)

Sod^1-108

Sod^h1

(Makunin et al., 2002)

Sodⁿ¹⁰⁸

(Strub et al., 2008, Phillips et al., 1995)

Sodⁿ¹

(Mishra et al., 2014, O'Keefe et al., 2011, Wang et al., 2011, Christensen et al., 2009.2.28, Rogina and Helfand, 2000)

cSODⁿ¹⁰⁸

(Draper et al., 2000, Parkes et al., 1998, The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Humphreys et al., 1996, Nappi et al., 1995, Lakhotia, 1994, Reveillaud et al., 1994, Hilliker et al., 1992, Staveley et al., 1990)

cSodⁿ¹⁰⁸

(Doran et al., 2017, Blackney et al., 2014)

dsod^G51S

(Şahin et al., 2017)

l-108

(Campbell et al., 1986)

sod1ⁿ¹⁰⁸

(Sun et al., 2012)

sod1ⁿ¹

(Milton et al., 2011)

sodⁿ¹⁰⁸

(Missirlis et al., 2001)

sodⁿ¹

(Kuronen et al., 2009)

Name Synonyms

Secondary FlyBase IDs

FBal0030259

References (36)

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