Sodn1 mutant glia exhibit lipid droplet accumulation.
Homozygous Sodn1 mutants are viable.
Compared to controls, Sodn1 mutant larvae show significantly higher oxidative DNA damage after the addition of DDVP (0.15-15.0ng/ml).
The supplementation of algal cells (from Haematococcus pluvialis) at high concentrations (10 and 20mg/mL) significantly extends the life span of Sodn1 mutant flies (while this concentration appears to be toxic to control flies). Low concentrations of algal cells do not have a significant effect on the life span of Sodn1 mutant flies.
The age-dependent decline in locomotor function in Sodn1 mutant flies is effectively rescued by the intake of Haematococcus pluvialis cells.
The lifespan of homozygous Sodn1 mutants is shorter than than of controls.
Chronic hypoxia (5% O[]) partially restores the abbreviated life span of mutant flies.
Homozygous flies show a reduction in adult lifespan compared to controls and are extremely hypersensitive to paraquat.
Homozygotes have a significantly shorter mean and maximum life span than normal; mean life span of the mutants is 12 days (compared to 40 days for controls) and maximum lifespan of the mutants is 24 days (compared to 70 days for controls).
Homozygous male escapers are sterile and female escapers have reduced fertility. Escapers have reduced longevity and are sensitive to paraquat, buthionine sulfoximine, ionising radiation and hyperoxia compared to control flies.
In Sodn1 eggs of L.boulardi are melanotically encapsulated but, in contrast to the wild-type, survive.
Homozygous adult eye has extensive necrotic lesions throughout the retina. Histological defects also extend into the adjacent lamina of the brain. This neuropathology is consistent with behavioural defects, including motor activity.
Homozygous larvae are poorly viable at 31oC.
Homozygotes that are also homozygous for ry301 or ry506 die during late metamorphosis and during the process of eclosion.
Homozygotes life span is 80% less than wild type.
Originally recovered as a lethal mutation; homozygotes die in the process of eclosion; rare eclosing adults are completely sterile, are devoid of SOD activity and die within 2-3 days; however, some derived sublines show higher adult survival. Surviving homozygous males are sterile and homozygous females produce few if any offspring. Reduced life span and fertility attributed to reduced capacity of embryos, larvae, and pupae to protect developing preimaginal cells from O2--initiated cytotoxic damage. Homozygotes hypersensitive to the O2--radical-generating compound, paraquat (1,1'-dimethyl-4,4'-bipyridinium dichloride) and copper ions.