FlyBase Allele Report: Dmel\Sos[34Ea-6]

General Information

Symbol

Dmel\Sos^34Ea-6

Species

D. melanogaster

Name

FlyBase ID

FBal0015965

Feature type

allele

Associated gene

Dmel\Sos

Associated Insertion(s)

Carried in Construct

Also Known As

Sos^SF15

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Rogge et al., 1991)

Mutagen

ethyl methanesulfonate

(Ashburner et al., 1999.10.12, Woodruff and Ashburner, 1979)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

lethal | recessive

(The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Rogge et al., 1991, Woodruff and Ashburner, 1979)

Phenotype Manifest In

dorsal air sac primordium | somatic clone

(Cabernard and Affolter, 2005)

ommatidium | somatic clone

(Rogge et al., 1991)

Detailed Description

Statement

Reference

Sos^34Ea-6 homozygous clones in the dorsal air sac primordium grow more slowly than wild-type clones and never contribute to the tip of the primordium.

(Cabernard and Affolter, 2005)

Somatic mosaic analysis shows most ommatidia are normal but some lack a few receptor cells.

(Rogge et al., 1991)

strong allele

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Sos[+]/Sos^34Ea-6 is an enhancer of size defective | adult stage phenotype of sl²

(Murillo-Maldonado et al., 2011)

Suppressor of

Statement

Reference

Sos[+]/Sos^34Ea-6 is a suppressor | partially of increased cell number | adult stage phenotype of sl²

(Murillo-Maldonado et al., 2011)

Sos[+]/Sos^34Ea-6 is a suppressor of visible phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

Sos^34Ea-6 is a suppressor of visible phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

NOT Suppressor of

Statement

Reference

Sos^34Ea-6 is a non-suppressor of lethal | pupal stage phenotype of Csk^j1D8/Csk^S030003

(Read et al., 2004)

Phenotype Manifest In

Enhancer of

Statement

Reference

Sos[+]/Sos^34Ea-6 is an enhancer of wing blade phenotype of sl²

(Murillo-Maldonado et al., 2011)

Suppressor of

Statement

Reference

Sos[+]/Sos^34Ea-6 is a suppressor | partially of wing vein | ectopic phenotype of sl²

(Murillo-Maldonado et al., 2011)

Sos[+]/Sos^34Ea-6 is a suppressor | partially of photoreceptor cell R7 | adult stage phenotype of sl²

(Murillo-Maldonado et al., 2011)

Scer\GAL4^Tub.PU/Sos^34Ea-6 is a suppressor of wing vein phenotype of Scer\GAL4^Tub.PU, csw^Y279C.UASp

(Oishi et al., 2009)

Sos[+]/Sos^34Ea-6 is a suppressor of wing vein | ectopic phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

Sos^34Ea-6 is a suppressor of eye phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

Sos^34Ea-6 is a suppressor of eye phenotype of Egfr::tor^{t4021E.hs.sev}

(Dong et al., 1999)

Sos^34Ea-6 is a suppressor of photoreceptor cell R7 phenotype of Egfr::tor^{t4021E.hs.sev}

(Dong et al., 1999)

Sos^34Ea-6 is a suppressor of phenotype of sev::tor^13D.hs.sev

(Dong et al., 1999)

Sos[+]/Sos^34Ea-6 is a suppressor of phenotype of Src42A^Su(Raf)1-1

(Zhang et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of Sos^34Ea-6 enhances the reduction in wing blade area seen in homozygous sl² males.

One copy of Sos^34Ea-6 partially suppresses the ectopic wing vein phenotype seen in sl² homozygotes.

One copy of Sos^34Ea-6 partially suppresses the percentage of sl² mutant ommatidia that contain extra R7 photoreceptors.

(Murillo-Maldonado et al., 2011)

The presence of a Sos^34Ea-6 background significantly suppresses ectopic wing vein formation found in csw^{Y279C.Scer\UAS} (Scer\GAL4^tub) mutants.

(Oishi et al., 2009)

Dominantly suppresses the ability of Src42A^Su(phl)1-1 to suppress the lethality of phl¹/Y flies.

(Zhang et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

2240

b¹ Sos^34Ea-6 Adhⁿ⁴/CyO

Kyoto

106751

b¹ Sos^34Ea-6 Adhⁿ⁴/CyO

101320

b¹ Sos^34Ea-6 Adhⁿ⁴ / CyO, Duox^Cy dpy^lv1 pr¹ cn²

Notes on Origin

Discoverer

Ashburner.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

SF15

Sos³⁴

(Murillo-Maldonado et al., 2011)

Sos^34Ea-6

(Johns et al., 2018, Oishi et al., 2009, Oishi et al., 2006)

Sos⁶

(Iyengar et al., 1999)

Sos^SF15

(Dong et al., 1999)

Sos^sf15

(Rogge et al., 1991)

l(2)34Ea⁶

l(2)br24^SF15

(The Moscow Regional Drosophila melanogaster Stock Center, Dubna)

l(2)br25^SF15

(Woodruff and Ashburner, 1979)

sos^34Ea-6

(Settle et al., 2003)

sos^SF15

(Cabernard and Affolter, 2005)

sos^sf15

(Zhang et al., 1999)

Name Synonyms

Secondary FlyBase IDs

References (15)

Report Sections

Open Close