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General Information
Symbol
Dmel\speck1
Species
D. melanogaster
Name
FlyBase ID
FBal0015980
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
sp, sp1
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

7566bp 412 element is inserted in the 5'UTR in exon 1 of isoform RB of speck. The size, structure and location of the 412 insertion in speck1 is identical to that found in speck2 (the insertion in both mutants is represented by 412{}881 in the annotated reference genome).

Insertion of a 412 element within the transcription unit.

Known mutation in sequenced strain.

Insertion components
412{}881
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

speck1 adults exhibit ectopic pigmentation in the wing hinge.

speck1 pupal cases exhibit excess pigmentation at the anal pad.

Displays a marked decrease in the amount of the A2 component of phenoloxidase.

In pupa, region of anal papilla is dark.

Body colour: dark; axils of wings have black specks.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement
Reference

speck1 has phenotype, suppressible by su(sable)2

speck1 has phenotype, suppressible by svrpoi-dish

NOT suppressed by
Statement
Reference

speck1 has phenotype, non-suppressible by su(Hw)2

Enhancer of
Statement
Reference

speck1 is an enhancer of wing vein | adult stage phenotype of net1

Additional Comments
Genetic Interactions
Statement
Reference

The net1 phenotype (ectopic veins, vein networking) can be enhanced by combination with CycGHR7 but also by combination with mutant alleles of unrelated factors ru1 or sp1 demonstrating high susceptibility of the net1 phenotype to perturbed genetic background.

The levels of the A2 component of phenoloxidase are restored to normal in presence of su(s)2.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (1)
Stocks (421)
Notes on Origin
Discoverer

Morgan, March 1910.

Comments
Comments

Marker mutation present in the strain used in the genome sequencing project.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Name Synonyms
olive-2
Secondary FlyBase IDs
    References (16)