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General Information
Symbol
Dmel\wgSp-1
Species
D. melanogaster
Name
Sternopleural
FlyBase ID
FBal0015984
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Sp
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Polytene chromosomes apparently normal (Morgan, Bridges and Schultz, 1937).
Nature of the lesion
Statement
Reference
Mutation in the 3' regulatory region of wg.
Regulatory mutation.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
The anterior dorsocentral bristle is missing in 61% of wgSp-1/wgl-17 flies. When present, it is 14% shorter than normal.
wgl-16/wgSp-1 females have reduced vaginal plates and tergite eight and the vulva is mainly absent. wgl-16/wgSp-1 males lack the penis apparatus and most of the clasper, and the lateral plates are fused.
wgl-12/wgSp-1 flies lack the anterior dorsocentral bristle.
A rearrangement and increase in the number of large bristles on the sternopleurite. When in combination with wgspd-fg homozygotes the level of wing etching is increased (compared to wgspd-fg homozygotes). When in combination with other null or hypomorphic alleles the mutants are viable. Transheterozygotes lose one or both of the anterior dorsocentral macrochaetes. Transheterozygotes with wgSp-1 exhibit occasional etching of the wing margin and hold their wings in an abnormal out-stretched position.
Homozygous second leg imaginal dics exhibit a severe overgrowth on the dorsal side causing additional folds. wgP/wgSp-1 and wgl-16/wgSp-1 individuals are lethal. Adult escapers from this cross lack one or both anterior dorsocentral bristles and more rarely also the posterior postalar bristle and the presutural bristle. They also exhibit loss of distal antennal segments and in rare cases exhibit antennal duplication. wgl-17/wgSp-1 flies are viable and exhibit loss of anterior dorsocentrals and loss of microbristles located in the wg-expression domain of the notum. wgl-17/wgSp-1 flies in addition exhibit loss of distal antennal segments. Individual in combination with wgSp-revP are pupal lethal and in combination with wg1 are wild-type.
Extra bristles on the sternopleurite.
Sternopleural bristles increased in number. At 19oC, wild type; at 25oC, overlaps wild type; at 28oC-30oC, no overlap. Apparently does not affect sternopleural bristles on metathoracic segment converted by bx to a mesothoracic segment (Waddington, 1939). RK2. Homozygous lethal.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference
wgSp-1/wg[+] is a non-suppressor | partially of visible phenotype of mir-965KO1/mir-965KO2
Phenotype Manifest In
Suppressed by
NOT suppressed by
Statement
Reference
wgSp-1 has phenotype, non-suppressible by su(Hw)2
Suppressor of
Statement
Reference
wgSp-1, wg[+], stg4, stg[+] is a suppressor | partially of abdomen phenotype of mir-965KO1/mir-965KO2
wgSp-1/wg[+] is a suppressor | partially of abdomen phenotype of mir-965KO1/mir-965KO2
NOT Suppressor of
Statement
Reference
wgSp-1/wg[+] is a non-suppressor | partially of abdomen phenotype of mir-965KO1/mir-965KO2
Additional Comments
Genetic Interactions
Statement
Reference
One copy of wgSp-1 partially suppresses the segment gap phenotype seen in the abdomens of mir-965KO1/mir-965KO2 mutant flies. One copy each of stg4 and wgSp-1 partially suppresses the segment gap phenotype seen in the abdomens of mir-965KO1/mir-965KO2 mutant flies.
Expression of pnrSA.Scer\UAS.β under the control of Scer\GAL4pnr-MD237 results in greater rescue of the loss of dorsocentral bristles seen in wgSp-1/wgl-17 flies than expression of pnrScer\UAS.β under the control of Scer\GAL4pnr-MD237. Expression of scSA.Scer\UAS under the control of Scer\GAL4DC results in greater rescue of the loss of dorsocentral bristles seen in wgSp-1/wgl-17 flies than expression of scScer\UAS.cUa under the control of Scer\GAL4DC.
The wgSp-1 mutation is able to suppress the increase in extra macrochaetae seen when NcC318G.Scer\UAS is expressed under the control of Scer\GAL4sca-P309.
Flies expressing tkvQ199D.Scer\UAS.cTa under the control of Scer\GAL4tsh-Gal4-1 in a wgl-12/wgSp-1 background do not have any ectopic dorsocentral bristles, although they have ectopic anterior postalar and posterior supraalar bristles.
Xenogenetic Interactions
Statement
Reference
wgSp-1/+ significantly partially suppresses the decreased lifespan seen in flies with expression of Hsap\HTTQ93.ex1p.Scer\UAS driven by Scer\GAL4elav.PU.
Complementation and Rescue Data
Partially rescued by
Comments
Expression of wgScer\UAS.cLa under the control of Scer\GAL4cad-em459 in wgl-16/wgSp-1 females sometimes results in recovery of the vaginal plates and tergite eight, but not the vulva. The analia are much reduced in some cases and some females have no genital and anal structures. Expression of wgScer\UAS.cLa under the control of Scer\GAL4cad-em459 in wgl-16/wgSp-1 males results in recovery of genital structures such as the claspers and penis apparatus, although the penis apparatus is sometimes still reduced. Analia are almost normal or reduced.
Images (0)
Mutant
Wild-type
Stocks (409)
Notes on Origin
Discoverer
M. (Mann) Lesley.
Comments
Comments
Loss of function phenotype in the wing, antennae and notal bristles but gain of function phenotype in the legs and aDC bristles (rescues wg loss of function).
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
References (24)