Open Close
General Information
Symbol
Dmel\mus301660
Species
D. melanogaster
Name
FlyBase ID
FBal0016038
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
spn-C660
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

T8140021A

Reported nucleotide change:

T2185A

Amino acid change:

M665K | mus301-PA

Reported amino acid change:

M665K

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: M665K.

Nucleotide substitution: T2185A.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

100% of mus301660/Df(3L)66C-G28 egg chambers have a mutant karyosome, 4% have misplaced oocytes and 4% have small oocytes. 30% of eggs laid by mus301660/Df(3L)66C-G28 females are ventralised.

98% of mus301660/mus301D1 egg chambers have a mutant karyosome. 45% of eggs laid by mus301660/mus301D1 females are ventralised.

mus301660/Df(3L)66C-G28 females show 41% X chromosome nondisjunction. mus301660/Df(3L)ZP3 females show 42% X chromosome nondisjunction.

mus301660/Df(3L)66C-G28 and mus301094/mus301660 larvae are sensitive to MMS compared to controls.

Egg chambers of females exhibit a partially penetrant disruption in the positioning of the oocyte which can be located anywhere in the egg chamber.

In approximately 29% of mutant egg chambers, the oocyte fails to move to the posterior and lies either at the anterior of the germline cyst or in the middle, with nurse cells on both sides. Follicle cells migrate to the middle of the bipolar egg chamber, to form a belt around the oocyte.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference

Df(3L)66C-G28/mus301660 has karyosome phenotype, non-suppressible by grpfsA4

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (6)