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General Information
Symbol
Dmel\spn-E2
Species
D. melanogaster
Name
FlyBase ID
FBal0016042
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
spn-E653, hlsE653
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

T15841351R

Amino acid change:

Y636term | spn-E-PA

Reported amino acid change:

Y636term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: Y636term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

meiosis & nuclear chromosome

meiosis & nuclear chromosome (with spn-E1)

Detailed Description
Statement
Reference

The eggs laid by spn-E2/spn-Ehls-Δ125 mutant females exhibit severe dorsoventral patterning defects, with a high percentage of collapsed eggs or eggs with no dorsal appendages.

spn-E2/spn-E1 larvae are not sensitive to MMS.

spn-E1/spn-E2 animals show the same survival rate after exposure to 0.08% methyl methanesulfonate as control animals.

Homozygotes and trans-heterozygotes with spn-E1 show an increased rate of non-disjunction in all except the small 4th chromosome. There are also substantial biases in recovery of reciprocal sperm classes. Nullo-XY sperm are recovered in considerable excess over the reciprocal XY sperm class. Also a weaker bias in favour of normal X-bearing sperm is seen.

Heterozygotes with Df(3R)sbd105 (spn-E-) exhibit mislocalised oocyte phenotype and degenerating egg chambers.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
  • FBal0045710
References (7)