Allele Dmel\spn-E²

General Information
Symbol	Dmel\spn-E²	Species	D. melanogaster
Name		FlyBase ID	FBal0016042
Feature type	allele	Associated gene	Dmel\spn-E
Also Known As	spn-E⁶⁵³, hls^E653

Allele class	hypomorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (Gillespie and Berg, 1995)
Mutagen	ethyl methanesulfonate (Tearle and Nusslein-Volhard, 1987, Gillespie and Berg, 1995)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	meiotic cell cycle defective (Stapleton et al., 2001) meiotic cell cycle defective (with spn-E¹) (Stapleton et al., 2001)
Phenotype Manifest In
	meiosis & nuclear chromosome (Stapleton et al., 2001) meiosis & nuclear chromosome (with spn-E¹) (Stapleton et al., 2001)
Detailed Description
	Statement Reference spn-E²/spn-E¹ larvae are not sensitive to MMS. (McCaffrey et al., 2006) spn-E¹/spn-E² animals show the same survival rate after exposure to 0.08% methyl methanesulfonate as control animals. (Abdu et al., 2003) Homozygotes and trans-heterozygotes with spn-E¹ show an increased rate of non-disjunction in all except the small 4th chromosome. There are also substantial biases in recovery of reciprocal sperm classes. Nullo-XY sperm are recovered in considerable excess over the reciprocal XY sperm class. Also a weaker bias in favour of normal X-bearing sperm is seen. (Stapleton et al., 2001) Heterozygotes with Df(3R)sbd105 (spn-E^-) exhibit mislocalised oocyte phenotype and degenerating egg chambers. (Gillespie and Berg, 1995)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Weak mutation. (Gonzalez-Reyes et al., 1997)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	fs(3)hls^E653 hls^E653 (Stapleton et al., 2001, Gillespie and Berg, 1995) spn-E² spn-E⁶⁵³ (Abdu et al., 2003, Gonzalez-Reyes et al., 1997, Tearle and Nusslein-Volhard, 1987, McCaffrey et al., 2006)
Name Synonym
Secondary FlyBase IDs
	FBal0045710
References ( 6 )
Research paper	McCaffrey et al., 2006, Genetics 174(3): 1273--1285 Drosophila mus301/spindle-C encodes a helicase with an essential role in double-strand DNA break repair and meiotic progression. [FBrf0192058] Abdu et al., 2003, Genetics 165(1): 197--204 The Drosophila spn-D gene encodes a RAD51C-like protein that is required exclusively during meiosis. [FBrf0162153] Stapleton et al., 2001, Chromosoma 110(3): 228--240 A role of the Drosophila homeless gene in repression of Stellate in male meiosis. [FBrf0138260] Gonzalez-Reyes et al., 1997, Development 124(24): 4927--4937 Oocyte determination and the origin of polarity in Drosophila: the role of the spindle genes. [FBrf0100046] Gillespie and Berg, 1995, Genes Dev. 9(20): 2495--2508 Homeless is required for RNA localization in Drosophila oogenesis and encodes a new member of the DE-H family of RNA-dependent ATPases. [FBrf0083956]
Stock list	Tearle and Nusslein-Volhard, 1987, D. I. S. 66: 209--269 Tubingen mutants and stock list. [FBrf0045941]

Allele Dmel\spn-E2

Allele Dmel\spn-E²