A Database of Drosophila Genes & Genomes

FB2008_06, released July 3, 2008
 

Allele Dmel\sr1

General Information
SymbolDmel\sr1SpeciesD. melanogaster
NameFlyBase IDFBal0016068
Feature typealleleCreated / Updated2006-08-22/2006-08-22
Associated geneDmel\sr
Allele class
Mutagenspontaneous
hide Nature of the Allele
Allele class
Mutagen
spontaneous
(Lee et al., 1995)
Mapped Features and Mutations
Type
Symbol & Location
Additional Notes
References
 
 
 
 
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Progenitor genotype
      Nature of the lesion
      Statement
      Reference
       
       
      Assay mode
      Carried on aberration
      Dp(3;3)Cam36
      (Roote, 2000.3.14, Roote, 2004.6.24)
      DcxF-Sse
      (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
      C(3R)RM-P3
       
      Cytology
      hide Phenotypic Data
      hide Phenotypic Class
      viable
      (Usui et al., 2004)
      flightless | recessive
      (Homyk and Emerson, 1988)
      hide Phenotype Manifest In
      dorsal medial muscle
      (Lee et al., 1995)
      hide Detailed Description
      Statement
      Reference
      Trident pattern on thorax replaced by broad light gray stripe at 25oC; stripe is dark at 18oC or in the presence of heterozygous or homozygous b or e. Homozygotes are flightless (Levine and Wyman, 1973) and show a reduction in size of a specific indirect flight muscle, the dorsal longitudinal muscle (DLM). The DLM is absent from sr1/Df(3R)sr- adults. Early development of the indirect flight muscles is normal, but in the thirty-five-hour pupa the DLM begins to degenerate leading to its absence in adults (Costello and Wyman, 1986).
       
      sr1/sr61j show a variable sr phenotype that overlaps with wild-type.
      (Puro, 1982)
      Homozygotes are flightless, and have a normal wing posture.
      (Homyk and Emerson, 1988)
      Homozygotes have muscular and cuticular defects. Double heterozygotes with sr5, sr6, sr155, Df(3R)P14, sr461, srR947, sr61j and srbsc have muscular and cuticular defects.
      (de la Pompa et al., 1989)
      Homozygotes exhibit a significant reduction in DLM size.
      (Lee et al., 1995)
      hide Interactions
      hide Phenotypic Class
      hideEnhancer of
      Statement
      Reference
      sr1 is an enhancer of visible phenotype of acHw-1
      (Usui et al., 2004)
      hide Phenotype Manifest In
      hideEnhancer of
      Statement
      Reference
      sr1 is an enhancer of mesothoracic tergum & macrochaeta | ectopic phenotype of acHw-1
      (Usui et al., 2004)
      hide Additional Comments
      hide Genetic Interactions
      Statement
      Reference
      acHw-1 ; sr1 double mutant flies have a broader distribution of ectopic bristles over the notum than in flies mutant for acHw-1 alone. This effect is synergistic; the double mutant displays more bristles than the sum of the two single mutants.
      (Usui et al., 2004)
      hide Xenogenetic Interactions
      Statement
      Reference
      hide Complementation & Rescue Data
      Comments
      hide Stocks ( 207 )
      Bloomington
      598
      sr1
      599
      sr1 gl1
      519
      Hnr3 sr1
      554
      pp Ubxbx-1 sr1 es
      6173
      Df(3R)T-55, cu1 sr1 es/MRS
      5701
      w*; sr1 ninaE17 es
      Kyoto
      106000
      sr1
      105959
      Hnr3 sr1
      101657
      In(1)wm4h ; sr1 gl1
      105978
      pp Ubxbx-1 sr1 es
      108669
      Df(3R)T-55, cu1 sr1 es/MRS
      108377
      w*; sr1 ninaE17 es
      hide Notes on Origin
      Discoverer
      Bridges, Feb. 1922.
      hide Synonyms & Secondary IDs ( 3 )
      Reported As
      Symbol Synonym
      sr
      (Homyk and Emerson, 1988, Puro, 1982)
      sr1
      (Christensen et al., 2008.4.15)
      unnamed
      (Roote, 2004.6.24)
      Name Synonym
      Secondary FlyBase IDs
        hide References ( 14 )
        Research paper
        Usui et al., 2004, Curr. Biol. 14(12): 1047--1055
        Mutual exclusion of sensory bristles and tendons on the notum of dipteran flies. [FBrf0179495]
        Ghazi et al., 2000, Development 127(24): 5309--5318
        Apterous mediates development of direct flight muscles autonomously and indirect flight muscles through epidermal cues. [FBrf0131298]
        Frommer et al., 1996, EMBO J. 15(7): 1642--1649
        Epidermal egr-like zinc finger protein of Drosophila participates in myotube guidance. [FBrf0087142]
        Lee et al., 1995, Proc. Natl. Acad. Sci. USA 92(22): 10344--10348
        Identification of a Drosophila muscle development gene with structural homology to mammalian early growth response transcription factors. [FBrf0084118]
        de la Pompa et al., 1989, Dev. Biol. 131(2): 439--454
        Genetic analysis of muscle development in Drosophila melanogaster. [FBrf0049500]
        Homyk and Emerson, 1988, Genetics 119: 105--121
        Functional interactions between unlinked muscle genes within haploinsufficient regions of the Drosophila genome. [FBrf0048188]
        Puro, 1982, D. I. S. 58: 205--208
        Report of new mutants. [FBrf0037780]
        Craymer, 1980, D. I. S. 55: 197--200
        [New mutants report.] [FBrf0063385]
        Review
        Calleja et al., 2002, Gene 292(1-2): 1--12
        How to pattern an epithelium: lessons from achaete-scute regulation on the notum of Drosophila. [FBrf0151319]
        Personal communication to FlyBase
        Christensen et al., 2008.4.15, Isolation and characterization of Df(3R)BSC510.
        Isolation and characterization of Df(3R)BSC510. [FBrf0204570]
        Roote, 2004.6.24, Cam Dps.
        Cam Dps. [FBrf0178882]
        Bloomington Drosophila Stock Center, 2001.8.28, Balancer Variants.
        Balancer Variants. [FBrf0138610]
        Roote, 2000.3.14, Dp(3;3)Cam's.
        Dp(3;3)Cam's. [FBrf0126882]
        FlyBase analysis
        FlyBase Curators, 2006-, Balancer summary information.
        Balancer summary information. [FBrf0189689]